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Database: UniProt
Entry: A0A1D5P2S9_CHICK
LinkDB: A0A1D5P2S9_CHICK
Original site: A0A1D5P2S9_CHICK 
ID   A0A1D5P2S9_CHICK        Unreviewed;      2303 AA.
AC   A0A1D5P2S9;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   05-DEC-2018, entry version 15.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|Ensembl:ENSGALP00000046978};
GN   Name=ITPR2 {ECO:0000313|Ensembl:ENSGALP00000046978};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000046978, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000046978, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000046978,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000046978}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000046978};
RG   Ensembl;
RL   Submitted (OCT-2016) to UniProtKB.
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DR   EMBL; AADN04000045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGALT00000066797; ENSGALP00000046978; ENSGALG00000014071.
DR   GeneTree; ENSGT00940000156039; -.
DR   Reactome; R-GGA-114508; Effects of PIP2 hydrolysis.
DR   Reactome; R-GGA-139853; Elevation of cytosolic Ca2+ levels.
DR   Reactome; R-GGA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-GGA-5578775; Ion homeostasis.
DR   Reactome; R-GGA-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR   Proteomes; UP000000539; Chromosome 1.
DR   ExpressionAtlas; A0A1D5P2S9; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2213   2235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2247   2267       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2279   2299       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    358       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      364    420       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       89    109       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2303 AA;  261930 MW;  4485D3316506AD06 CRC64;
     MSEKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVQ PDAGDLANPP KKFRDCLFKV
     CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENRKL LGEIVKYSNV
     IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIQPFWKLR SEGDNVVVGD
     KVVLMPVNAG QPLHASNIEL LDNPGCKEVN AVNCNTSWKI TLFMKFSSYR DDVLKGGDVV
     RLFHAEQEKF LTCDEYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN
     SLFRFKHLAT GNYLAAEQRD GDLPASKKKR QAGEKIMYTL VSVPHGNDIA SLFELDATTL
     QRADCLVPRN SYVRLRHLCT NTWVTSTSIP IDTNEERPVM LKIGTCQTKE DKEAFAIVSV
     PLSEVRDLDF ANDANKVLAS TVKKLENGTI TQNERRFVTK LLEDLIFFVS DVPNNGQEVL
     DVVITKPNRE RQKLMREQNI LAQIFGILKA PFKDKGEGSM LRLEDLGDQR YAPYKYMLRL
     CYRVLRHSQQ DYRKNQEYIA KNFCVMQSQI GYDILAEDTI TALLHNNRKL LEKHITAKEI
     ETFVNLLRRN REPRFLDYLS DLCVSNTTAI PVTQELICKF MLSPGNADIL IQTKLISTQM
     DNPLECPVIS DDIDEEEVWL YWIDSNKEPH GKAIRHLAQE AKEGTKVDLE VLTYYRYQLN
     LFARMCLDRQ YLAINQISAQ LSVDLILRCM SDESLPYDLR ASFCRLMLHM HVDRDPQESV
     VPVRYARLWT EIPTKITIHE YDSFTDSSRN EMKRKFALTM EFVEEYLKEV VNQPFPFGDK
     EKNKLTFEVV HLARNLIYFG FYSFSELLRL TRTLLAILDI VQVPMSSYFE RLSKFQDGGN
     NVMRTIHGVG EMMTQMVLSR GSIFPISVPD VQPSIHPSKQ ATTSENEDVI VMDTKLKIIE
     ILQFILSVRL DYRISYMLSI YKREFGENNE NVDSSTTSPP DASGIPSAIV PDIDEIAAQA
     ETMFAGRKEK NAVQLDDEGG RTFLRVLIHL IMHDYPPLLS GALHLLFKHF SQRAEVLQAF
     KQVQLLVSNQ DVDNYKQIKA DLDQLRLTVE KSELWVEKSS NYESGEGGDN QTKGGEEPIE
     EPNILSPIQD GTKKPQIDSN KSNNYNIVKE ILVRLSKLCV QNKKCRNQQQ RLLKNMGAHL
     VVLDLLQIPY EKSDEKMNEV MNLAHTFLQN FCRGNPQNQV LLHKNLNLFL TPGLLEAETM
     RHIFMNNYLL CNEISERVVQ HFVHCIETHG RHVEYLRFLQ TIVKADGKYV KKCQDMVMTE
     LINGGEDVLI FYNDRASFPV LLQMMCSERD RADESGPLAY HITLVELLAA CTEGKNVYTE
     IKCNSLLPLD DIVRVVTHDD CIPEVKIAYV NFVNHCYVDT EVEMKEIYAS NHIWKLFENF
     LVDMARVCNT TTDRKHADTS LEKYVTEPVM SIVSGFFNSP FSDNSTSLQT HQPVFIQLLQ
     SAFRIYNCTW PNPTQKASVE SCIKTLAEVA KNRGIAIPVD LDSQVNTLFM KSHSNMVQRA
     AMGWRMSARS GPRFKEALGG PAWDYRNIIE KLQDVVSSLE QQFTPMMQAE FSVLVDVLHS
     PELLFPEGSD ARIRCGAFMS KLINHTKKLM EKEEKLCIKI LQTLREMLDK KTNFAEEGNT
     LRKILLYRYF KGEYGSGMNG PLSASYSKTA QVGGGFVGQD SDKSGVSMFD IQCLLDKEGA
     SELVIDVIVS TKNDRIFSEG ILLGIALLEG GNAQTQYSTY QQLKEQKKSE KFFKVLYDRM
     KAAQQEIRST VTVNTIDLGS KKKDDDSDLT ISVPKKRVKD STLHLKEGMK VQLTEASSAT
     SKAYSVYRRE MDPEIDLMGS GTDAANAEEK STEEAVMSPA IAIMQPILRF LQLLCENHNR
     ELQNFLRHQN NKTNYNLVCE TLQFLDCICG STTGGLGLLG LYINERNVAL VNQTLESLTE
     YCQGPCHENQ TCIATHESNG IDIIIALILN DINPLGKYCM DLVLQLKNNA SKLLLAIMES
     RQDSENAERI LFNMRPKELV DVMKNAYNQG LECDHEEENG DDGISPKDVG HNIYILAHQL
     ARHNKTLQQM LKPGSDPDEG DEALSHYANH TAQIEIVRHD RTMEQIVFPV PNICEFLTRE
     SKSRVFNTTE RDEQGSKVND FFQQTEDLYN EMKWQKKIRN NPLLFWFSRH ISLWGSISFN
     LAVFINLAVA LFYPFGDDGD EGTLSPLISV LLWIAVALCT AMLFFISKPV GIRPFLVSVI
     LRSIYTIGLG PTLILLGAAN VST
//
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