ID A0A1D5P3M3_CHICK Unreviewed; 407 AA.
AC A0A1D5P3M3;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Potassium two pore domain channel subfamily K member 13 {ECO:0000313|Ensembl:ENSGALP00010025035.1};
GN Name=KCNK13 {ECO:0000313|Ensembl:ENSGALP00010025035.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010025035.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010025035.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010025035.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR RefSeq; XP_001235376.1; XM_001235375.3.
DR AlphaFoldDB; A0A1D5P3M3; -.
DR STRING; 9031.ENSGALP00000047278; -.
DR PaxDb; 9031-ENSGALP00000017342; -.
DR Ensembl; ENSGALT00010042545.1; ENSGALP00010025035.1; ENSGALG00010017599.1.
DR GeneID; 772210; -.
DR KEGG; gga:772210; -.
DR CTD; 56659; -.
DR VEuPathDB; HostDB:geneid_772210; -.
DR GeneTree; ENSGT00940000157960; -.
DR InParanoid; A0A1D5P3M3; -.
DR OMA; NFTRRHN; -.
DR OrthoDB; 600333at2759; -.
DR Reactome; R-GGA-1299287; Tandem pore domain halothane-inhibited K+ channel (THIK).
DR Reactome; R-GGA-5576886; Phase 4 - resting membrane potential.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000010672; Expressed in granulocyte and 4 other cell types or tissues.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR005410; 2pore_dom_K_chnl_THIK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF57; POTASSIUM CHANNEL SUBFAMILY K MEMBER 13; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01588; THIKCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT DOMAIN 87..150
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 200..284
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
SQ SEQUENCE 407 AA; 45548 MW; 5AB0040EE422269B CRC64;
MACGGCCCSG AGRLNADNAR FLLLAVLIAL YMLCGAAVFS AIELPGERRA KQRWEERLQN
FTRRHNLSRA ELRDFLREYE EASVAGIRVD DIRPRWDFTG AFYFVGTVVS TIGFGMTTPA
TVGGKIFLIF YGLIGCAGTI LFFNLFLERL ITVIAYVMKS CHERQLRRKG VLPHDGRRGS
GTSEADSLAG WKPSVYYVML ILCIASLIIS CCASAMYTPI EGWSYFDSLY FCFVAFSTIG
FGDLVSSQNT HYESQGLYRF GNFVFILMGV CCIYSLFNVI SIVIKQSINW ILKKLDCRCC
HRCQRKLFRS RRNVVMPGNV RGRRNISIET DIVNESDTDG RRLSGEMISM KDFLASNKVS
LAIMQKQLSE TANGYPRQMS SKQNGFSGGV GALAIMNNRL AETSVDR
//
