ID A0A1D5P588_CHICK Unreviewed; 894 AA.
AC A0A1D5P588; A0A2H4I7A1;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=G protein-coupled receptor 133 variant X2 {ECO:0000313|EMBL:ART34152.1};
GN Name=GPR133 {ECO:0000313|EMBL:ART34152.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ART34152.1};
RN [1] {ECO:0000313|EMBL:ART34152.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Hypothalamus {ECO:0000313|EMBL:ART34152.1};
RA Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA Babar A., Rosenke K.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR EMBL; KX163098; ART34152.1; -; mRNA.
DR RefSeq; XP_415094.4; XM_415094.5.
DR AlphaFoldDB; A0A1D5P588; -.
DR GeneID; 416803; -.
DR CTD; 283383; -.
DR VEuPathDB; HostDB:geneid_416803; -.
DR Bgee; ENSGALG00000002557; Expressed in heart and 5 other cell types or tissues.
DR ExpressionAtlas; A0A1D5P588; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15256; 7tmB2_GPR133; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF216; ADHESION G-PROTEIN COUPLED RECEPTOR D1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|EMBL:ART34152.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 586..830
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 894 AA; 100061 MW; 9DBF631B461AD9F9 CRC64;
MIENLQEFDL GCTSNLTLTM KNLLSLLCCR YSLLILFQFK YQVYGNYSQL LEHPGFKVFS
SASHYWPLED VDGIHEFRDT NGDIVEGMVN KGIYVTEKKG VTFLFFGRYQ NSCISNPEVC
GPEGVTFSFF WKTQDQQTKF PPASGGQVIS SGFKICSSEG EGSVEFYTRG NAMMKWKASF
SPPGPYWTHI LFTWKSREGL KVYVNGTLNT TDPDGKVFYD YGDPSANLLT GTEGDQTKRY
VNGAFDEFII WERALTPNEI EQYFTAAIGV QFLLSSTLSW STMTTTTKPV LSTNAYHPII
TNLTKERGNF HSSDILLEYL ENVSFSLPNK SLSENTALSL TEAFLKVIED FLLLPNWLEI
PETAHIFGSL IQTIDSVMVH MTRNLEENSL SLTVEGSSSV ADYTLAKMHP KTLNLSHYRF
PSRGQSFISI PSEAFQERAW ITIVGMFYHN MHYYFHSINP MDTKIAEAAA YKGYMISAAS
YLISIKVDPP PKLSHNLSGS PLITIQLTHR LTPRQYSLAL NKSNRVHLYC AFLDYSNGTG
VWSNEGCVRE SGDLNYSVCL CNHLTNFAIL MQVVPLKLTR EHQVALSSIT YIGCALSIFC
LTITLVTFAV LSSVSTIRNQ RYHIHANLSF AVLVAQILLV TSFQFSPGTV PCKILAILLH
FFFLSAFAWM LVEGFHLYSM VIKVFGSEES KHLYYYGIGW GCPLVICVIS ATSSLDSYGE
SDNCWLSLEN GAIWAFVAPA LFVILVNIGI LIAVTRVISR ISADNYKVHG DANAFKLTAK
AVAVLLPILG SSWIFGILAI NAHTLIFQYM FAVFNSLQGF FMFLFHCLLN SEVRAAFKHK
TKVWSLTSSS ARNINVKPFN SDIMSGNRPG TTPTKLNTWD KSTNSANRID LSAV
//
