ID A0A1D5P6Q1_CHICK Unreviewed; 1219 AA.
AC A0A1D5P6Q1;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPN21 {ECO:0000313|Ensembl:ENSGALP00010025770.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010025770.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010025770.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010025770.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_015143216.1; XM_015287730.1.
DR AlphaFoldDB; A0A1D5P6Q1; -.
DR SMR; A0A1D5P6Q1; -.
DR STRING; 9031.ENSGALP00000048379; -.
DR Ensembl; ENSGALT00010043358.1; ENSGALP00010025770.1; ENSGALG00010017937.1.
DR GeneID; 423398; -.
DR KEGG; gga:423398; -.
DR CTD; 11099; -.
DR VEuPathDB; HostDB:geneid_423398; -.
DR GeneTree; ENSGT00940000155613; -.
DR InParanoid; A0A1D5P6Q1; -.
DR OMA; TEWDYIA; -.
DR OrthoDB; 3108587at2759; -.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000010616; Expressed in cerebellum and 12 other cell types or tissues.
DR ExpressionAtlas; A0A1D5P6Q1; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR CDD; cd17192; FERM_F1_PTPN21; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF3; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 21; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 2.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT DOMAIN 23..308
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 941..1212
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1123..1203
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1219 AA; 139207 MW; 7EDC9A3CA6704AD3 CRC64;
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE AVAQRLELRE
ITYFSLWYYN KQNQRRWVDL DKPLKKQLDK YALEPTVYFG VVFYVPTVSQ LQQEITRYQY
YLQLKKDILE GNIPCTLEQA IHLAGLAVQA DFGDYDQYES QEFLQRFALF PVGWLQEEKI
LEEATQKVAL LHQKYRGLTP PDAEMLYMQE VERMEGYGEE TYPAKDSQGS DIFIGACLDG
IFVKHKNSRP PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRMCVAR
HKFYRLNKCS LDSLDSPPEE GSQKSSLLLS LPRFPILSRP SLPKGQTQPI TVNPVRRRSS
SRMSMPKPQA YMMPPPPQLH YNGHYTEPYA SSQDNLFVSS QNGYYYHSQT SLDRAPHDYS
GRIRNGSVYS AHSTNSLNNP QHYLQPSPMS SNPSITGSDV LRTDYVPSHR HSALIPPSYR
PTPDYETVMR QLNRGMVHTD RQSHSMRNLN ISNTYAYSRP DALVYSQPEI REHAHFTSPQ
SNHYPFNLNY SFHSPSPYPY PAEKRPVVGA VSVPELTNVQ LQAQDYPAPN IMKTQVYRPP
PPYPYPRPAN STPDLSRHIY ISSSNPDLIT RRVHHSVQTF QEDSLPVAHS LQEVSEPLTS
ARHAQLQKRN SIEIAGLTPS FEGIRIKERT MSASAADVAL PRVISEGSQP NVLIERTKQK
ENEQDEGVNC DHKKTLSDAT MLIHSSEEEE EEFEENKAST SLSPLPEDQA QLSSIMGGYS
HDSVHNYPYS SVASSTGPLH ILEPKLHITE TEKRMKDISP VHLLVENQVQ RRGEGLLTPS
MSESDLTTSG RYRVRKDSVK KRPVSDLLSG KKNIVEGLPP LGGMKKNKTD AKKIGPLKLA
ALNGLTLARM PLPDEGKEES TRATNDERCK VLEQRLEQGM VFTEYERIQK KRLIDGECSI
ARLPENAERN RFQDVLPYDD TRVELVPTKE NNTGYINASH IKISVGGIEW DYIATQGPLQ
NTCQDFWQMV WEQGIAIIAM VTAEEESGRE KSFRYWPRLG SRHNTVTYGR FKITTRFRTD
SGCYATTGLK IKHLLTGQER TVWHLQYTDW PEHGCPEDLK GFLSYLEEIQ SVRRHTNSTA
DPKNSNPPVL VHCSAGVGRT GVVILSEIMI ACLEHNEMLD IPRVLDMLRH QRMMMVQTLS
QYTFVYGVLI QFLKSSRLI
//