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Database: UniProt
Entry: A0A1D5P6Q7_CHICK
LinkDB: A0A1D5P6Q7_CHICK
Original site: A0A1D5P6Q7_CHICK 
ID   A0A1D5P6Q7_CHICK        Unreviewed;      1613 AA.
AC   A0A1D5P6Q7;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   11-DEC-2019, entry version 25.
DE   SubName: Full=Rho GTPase activating protein 35 {ECO:0000313|Ensembl:ENSGALP00000048386};
GN   Name=ARHGAP35 {ECO:0000313|Ensembl:ENSGALP00000048386};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000048386, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000048386, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000048386,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA   Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA   Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA   Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA   McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA   Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA   Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA   Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA   Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA   Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA   Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA   Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA   Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA   Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA   Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA   Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA   Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA   Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA   Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA   Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA   Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA   Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA   Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA   Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA   Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA   Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA   Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA   Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide unique
RT   perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000048386}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000048386};
RG   Ensembl;
RL   Submitted (OCT-2016) to UniProtKB.
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DR   EMBL; AADN05001578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGALT00000065617; ENSGALP00000048386; ENSGALG00000036101.
DR   GeneTree; ENSGT00950000182819; -.
DR   OMA; WAPGSDG; -.
DR   Proteomes; UP000000539; Chromosome 32.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR   GO; GO:0007413; P:axonal fasciculation; IEA:Ensembl.
DR   GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR   GO; GO:0031668; P:cellular response to extracellular stimulus; IEA:Ensembl.
DR   GO; GO:0021955; P:central nervous system neuron axonogenesis; IEA:Ensembl.
DR   GO; GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; IEA:Ensembl.
DR   GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR   GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IEA:Ensembl.
DR   GO; GO:0043116; P:negative regulation of vascular permeability; IEA:Ensembl.
DR   GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR   GO; GO:0045724; P:positive regulation of cilium assembly; IEA:Ensembl.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR   GO; GO:0008064; P:regulation of actin polymerization or depolymerization; IEA:Ensembl.
DR   GO; GO:0050770; P:regulation of axonogenesis; IEA:Ensembl.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0044319; P:wound healing, spreading of cells; IEA:Ensembl.
DR   Gene3D; 1.10.10.440; -; 2.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT   DOMAIN          388..445
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          486..540
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          547..601
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          603..668
FT                   /note="FF"
FT                   /evidence="ECO:0000259|PROSITE:PS51676"
FT   DOMAIN          710..882
FT                   /note="PG1 pseudoGTPase"
FT                   /evidence="ECO:0000259|PROSITE:PS51852"
FT   DOMAIN          898..1060
FT                   /note="PG2 pseudoGTPase"
FT                   /evidence="ECO:0000259|PROSITE:PS51853"
FT   DOMAIN          1361..1548
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          62..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1078..1110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1231..1252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1288..1351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1578..1613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          531..558
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          603..623
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1095..1110
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1231..1249
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1292..1306
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1332..1346
FT                   /note="Basic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1578..1599
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1613 AA;  179865 MW;  5F25E11EEFB8C920 CRC64;
     MPIFSPVMAE LWQNCAHFHP SSHPAAPYSD ITAELCPFSA QLCQNCDIIP PTHPAALTLL
     SLPQGPPSAA PRRSPATPEL PHGHGDAAVV VSPSSTPPPI PAATDPLGRA LGQDVRTTMM
     MARKQDARIP TYNISVVGLS GTEKEKGQCG VGKSCLCNRF VRPSADEFHL DHTSVLSTSD
     FGGRVVNNDH FLYWGEVVRS LEECSECRAH VVEQTEFIDD QTFQPHRSTA LQPYIKRAAA
     TKLASAEKLM YFCTDQLGLE QDFEQKQMPD GKLLVDGFLL CIDVSRGMNR NFDEQLKFVS
     NLYNQLAKTK KPIVVVLTKC DEGVERYIRD AHAFALSKKN LQVVETSARS NVNVDLAFGT
     LVQLVDKSRG KTKIIPYFEA LKQQSQQIAA AKDKYEWLVS RVVKSHNETW AAVSRKMQPA
     PEYQDYVYLE GTPKAKKLFL QHVQRLKQEH IERRRRTYLA LLPQALDALV PNLDEIDHLS
     CSKVQRLLEG KGDFSKWFVV LEETPWDATS HIDSADAERI PFDVMETPAA EQLYEAHLER
     LRNERKRAEM RRAFQENLEA SPFVTPGKPW EEARSFIMNE DFYMWLEEPV YMDIYGKHQK
     RIIERAKEEF QELLLEYSEL FYELELDAKP SKEKMGVIQE VLGEEQRFKA LQKLQAERDA
     LILKHIHFVY HPTKETCPSC PLCVDSRVEQ LLGSRAARPA ERNQKNFLSD PNVDRINLVI
     LGKDGLAREL ANEIRALCTN DDKYVIEGKM YELSLRPIEG NVRLPVNAFQ TPTFQPHGCL
     CLYNSKESLS YVVESIEKSA AGRRENHPAH LPLTLMLVNK RGDAGGETLH SLVQQGQQIA
     GKLQCVFLDP AAAGIAYGRS VNEKQISQVL KGLLDSKRNL SLVSVPSGLK ELADVELRVA
     MCFMCGDAAG ADELLAPILQ SPLCRPAPCG GSVLLELCLG QQRRRVELSL LSYHAAFGVR
     KSRLVHGYVV FYAAKRRASL AMLRAFLCEV QDVVPVQLVA LIDGSVDVLE SDVSREQVAE
     GEEIAQEIDG KFAAVAYGQA QPKLDSFHAF FKEALEKKTL VEAMHMYDHA AEACGAEEAA
     GSPRAASPQC NSHPPDSEED AEPSPYGFCR DDVALPKEHS KLSVELEGND GLAFISVVSA
     FESKLNSKVP PPVKPKPPVP FELGKGDLTY LEQGQRKSVS CGSWPPADAF DPSDYAEPLD
     AVLKPKSEEE NIYSVPHDST QGKIITIRNI NKSQPNGGAN NGSDSEADSS SLERGGRKLS
     LLAKPALYRT RCARLGRFAS YRSSFGVGSD DELGPIRKKE EDQSSQGYKG DNAVIPYETA
     DGEDPRRRNI LRSLRRTTKK PKPKPRPSLT KPMWESSYFG VPLSSVVTPE KPIPIFIERC
     IEYIEATGLS TEGIYRVSGN KSEMESLQRQ FDQDHSLDLA EKDFTVNTVA GAMKSFFSEL
     PEPLVPYSMQ VELVEAHKIN DREQKLHALK EVLRKFPKEN YEVFKYVIGH LNKVSHHHRV
     NLMTSENLSI CFWPTLMRPD FSTMDALTAT RTYQTIIELF IQQCPFFFYH RPILDPPSAA
     PASPSAAVPP PGVVIPFAPV ATQPSPPRTP PPSPQSPVQA LLPAPLHAEQ HSL
//
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