GenomeNet

Database: UniProt
Entry: A0A1D5PAZ1_CHICK
LinkDB: A0A1D5PAZ1_CHICK
Original site: A0A1D5PAZ1_CHICK 
ID   A0A1D5PAZ1_CHICK        Unreviewed;      4950 AA.
AC   A0A1D5PAZ1;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   13-FEB-2019, entry version 19.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSGALP00000049908};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000049908, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000049908, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000049908,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000049908}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000049908};
RG   Ensembl;
RL   Submitted (OCT-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AADN04000071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGALT00000062448; ENSGALP00000049908; ENSGALG00000010812.
DR   GeneTree; ENSGT00940000154906; -.
DR   OrthoDB; 5161at2759; -.
DR   Reactome; R-GGA-2672351; Stimuli-sensing channels.
DR   Reactome; R-GGA-5578775; Ion homeostasis.
DR   Proteomes; UP000000539; Chromosome 3.
DR   ExpressionAtlas; A0A1D5PAZ1; baseline and differential.
DR   GO; GO:0034704; C:calcium channel complex; IBA:GO_Central.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4266   4292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4483   4503       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4557   4576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4693   4714       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4751   4772       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4827   4850       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    219       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      227    282       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      288    345       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      353    410       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      613    811       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1027   1224       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1359   1564       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4009   4044       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED       82    102       {ECO:0000256|SAM:Coils}.
FT   COILED      474    494       {ECO:0000256|SAM:Coils}.
FT   COILED     1856   1876       {ECO:0000256|SAM:Coils}.
FT   COILED     3057   3077       {ECO:0000256|SAM:Coils}.
FT   COILED     4195   4215       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4950 AA;  563297 MW;  A92DA3854AFE7758 CRC64;
     MTLYVLPQVR SITTVLYFFF FWKDDEVVLQ CTATVHKEQQ KLCLAAEGFG NRLCFLESTS
     NSKNVPPDLS ICTFVLEQSL SVRALQEMLA NTEEKAEGLV DVEKWSAQGG GHRTLLYGHA
     ILLRHSYSGM YLCCLSTSRS SMDKLAFDVG LQEDTTGEAC WWTIHPASKQ RSEGEKVRVG
     DDLILVSVSS ERYLHLSYGN GSLHVDAAFQ QTLWSVAPIS SGSEFAQGYL IGGDVLRLLH
     GHMDECLTVP SGEHGEEQRR TVHYEGGAVS IHARSLWRLE TLRVAWSGSH IRWGQPFRLR
     HITTGKYLSL LDDKSLLLTD KEKADIKSTA FCFRSSKEKL DVGMRKEVDG MGTPEIKYGD
     SICFIQHVDT GLWLSYQSAD AKSVRMGSVQ RKAIMHHEGH MDDGLTLSRS QHEESRTARV
     IRSTVFLFNR FIRGLDALSK KVKSSTVDLP IESVSLSLQD LIGYFHPPDE HLEHEDKQNR
     LRALKNRQNL FQEEGMINLV LECIDRLNVY SSAAHFADVA GKEAGEAWKS ILNSLYELLA
     ALIRGNRKNC AQFSGSLDWL ISRLERLEAS SGILEVLHCV LVESPEALNI IKEGHIKSII
     CLLDKHGRNH KVLDVLCSLC VCHGVAVRSN QHLICDNLLP GRDLLLQTRL VNHVSSMRPN
     IFLGISEGSA QYRKWYYELM VDHLEPFVTA ESTHLRVGWA STEGYSPYPG GGAEWGGNGV
     GDDLYSYGFD GLHLWSGCVA RTVNSPNQHL LRTEDVISCC LDLSAPSISF RINGQPVQGM
     FENFNIDGLF FPVVSFSAGI KVRFLLGGRH GEFKFLPPPG YAPCFEAVLP KEKLKVEHSR
     EYKQDRNYTR DLLGPTLNLS QAAFTPVPVD TSQIVLPPHL ERIREKLAEN IHELWVMNKI
     ELGWQYGPVR DDNKRQHPCL VEFSKLPEQE RNYNLQMSLE TLKTLLALGC HVGIADERAE
     EKVKKMKLPK NYQLLSGYKP APMDLSFIKL TPSQEAMVDK LAENAHNVWA RDRIRQGWTY
     GIQQDVKNRR NPRLVPYALL DDRTKKSNKD SLREAVRTLL GYGYNLEAPD QDHATRVDMS
     NGIMEKFRIF RTEKTYAVKS GKWYFEFEAV TAGDMRVGWT RPGCLPDQEL GSDEEAFVFD
     GFKAQRWHQG NEHFGRSWLA GDVVGCMVDM NEHTMMFTLN GEILLDDSGS ELAFKDFEVG
     DGFLPVCSLG PSQVGRMNFG KDVSTLKYFT ICGLQEGYEP FAVNTNRDIT IWLSKRLPQF
     LPVPQNHEHI EVMRIDGTID TCPCLKVTQK SFGSQNSKTD VMFFRLSMPI ECAEVFSRTA
     AGGLPGTGLF GPKNDLEDYD ADSDFEVLMK TAHGHLAADR TEREKDATKP ELNNHKDYVQ
     EKPSRLKQRF MLRRTKPDYS TSHSARLTED VLADDRDDYD YLMQTSTYYY SVRIFPGQEP
     ANVWVGWITS DFHQYDTSFD LDRVRTVTVT LGDEKGKVHE SIKRSNCYMV CAGESMSPGQ
     GRNNNGLEIG CLVDAASGLL TFTANGKELG TYYQVEPSTK LFPAVFAQAT SPNVFQFELG
     RIKNVMPLSA GLFKSEHKNP VSQCPPRLHV QFLTHVLWSR VPNHFLKVDV SRISERQGWM
     IQCLNPLQFM ALHIPEENRT IDILELTEQE ELLKFHYHTL RLYSAVCALG NNRVAHAMCS
     HVDESQLLYA IENKYMPGLL RAGYYDLLID IHLNTYATAR LMMNNEFIVP MTDETKSITL
     FPDENKKHGL PGIGLSTSLR PRMQFSSPSF VSINSECFQF SPEFPLEILK AKTIEMLTEA
     VQEGSLHVRD PVGGSTEFLF VPLIKLFYTL LIMGIFHNGD LKHILQLIEP RVFKEAASLE
     DEKDLSEKEL SSDELKSGEE ESRGEQVPKE GLLQMKLPEP VKLQMCHLLQ YLCDCQVRHR
     IEAIVAFSDD FVAKLQENQR FRYNEVMQAL NMSAALTARK TKEFRSPPQE QINMLLNFKD
     DKTDCPCPEE IRDQLLDFHE DLMTHCGIEL DEDGTLDGNS DLTIRGRLLY LVEKVTYLKK
     KQAEKPVDDD AKTSSTLQQL ISDTMVRWAQ ESVIEDPELV RAMFVLLHRQ YDGIGGLVRA
     LPKTYTINSV SVEDTINLLA SLGQIRSLLS VRMGKEEEKL MIRGLGDIMN NKVFYQHPNL
     MRALGMHETV MEVMVNVLGG GESKEITFPK MVANCCRFLC YFCRISRQNQ KAMFDHLSYL
     LENSSVGLAS PSMRGSTPLD VAAASVMDNN ELALALREPD LEKVVRYLAG CGLQSCPLLI
     SKGYPDIGWN PVEGERYLDF LRFAVFCNGE SVEENANVVV RLLIRRPECF GPALRGEGGN
     GLLAAMEEAI QISEDPTRDG PSPNNGSSKT LEMEEQEDDT IHMGNAIMTF YAALIDLLGR
     CAPEMHLIHA GKGEAIRIRS ILRSLIPLED LVGVISIPFH MPTIAKDGTV VEPDMSAGFC
     PDHKAAMVLF LDRVYGIEDQ DFLLHLLEVG FLPDLRAAAS LDTAALSATD MALALNRYLC
     TAVLPLLTRC APLFAGTEHH ASLIDSLLHT VYRLSKGCSL TKAQRDSIEE CLLSICGQLR
     PSMMQHLLRR LVFDVPLLNE HAKMPLKLLT NHYERCWKYY CLPGGWGNFG AASEEELHLS
     RKLFWGIFDA LSQKKYEQEL FKLALPCLSA VAGALPPDYM ESNYVNMMEK QSSMDSDGNF
     NPQPVDTSNI TIPEKLEYFI NKYAEHSHDK WSMEKFANGW TYGETYSESA KVQPLMKQYK
     LLSEKEKEIY RWPIKESLKT MLAWGWRIER TREGDSMALY NRTRRISQTS QISVDAAHGY
     SPRAIDMSNV TLSRDVHAMA EMMAENYHNI WAKKKKMELE AKGGGNHPLL VPYDTLTAKE
     KAKDREKAQD ILKFLQINGY VVSRGLKDLE LDTPSIEKRF AYSFLQQLIR YVDEAHQYIL
     EFDGGSRGKG EHFPYEQEIK FFAKVVLPLI DQYFKNHRLY FLSAASRPLS TGGHASNKEK
     EMVTSLFCKL GVLVRHRISL FGNDATSIVN CLHILGQTLD ARTVMKTGLE SVKMALRAFL
     DNAAEDLEKT MENLKQGQFT HSRNQPKGVT QIINYTSVAL LPVLSSLFEH IGQHQFGEDL
     ILEDVQVSCY RILSSLYALG TSKSIYVERQ RSALGECLAA FSGAFPVAFL ETHLNKHNIY
     SIYNTKNARD RAVLNLPTSV EEVCPNIPSL VKLMEEIVEL AESGIRYTQM PHIMEVILPM
     LCSYMSHWWE HGPENNPDKV EVCCTALTSE HMNTLLGNIL KIIYNNLGID EGAWMKRLAV
     FSQPIISKAK PQLLKTHFLP LMDKLKKKAA VVVSDEEHLR AEGRGDMSEA ELLILDEFTT
     LARDLYAFYP LLIRFVDYNR AKWLKEPNPE AEELFRMVAE VFIYWSKSHN FKREEQNFVV
     QNEINNMSFL ISDTKSKMSK AAVSDQERKK MKRKGDRYSM QTSLIVAALK RLLPIGLNIC
     APGDQDLIAL AKNRFSMKDT EDEVRDIIRS NLHLQGKLED PAIRWQMALY KDLPNRTEDS
     SDPEKTVERV LDIANVLFHL EQVRDIFPIV EHPQRSKKAV WHKLLSKQRK RAVVACFRMA
     PLYNLPRHRA VNLFLQGYDK SWIETEEHYF EDKLIEDLAK PGEEPQEEDE SLKRVDPLHQ
     LILLFSRTAL TEKCKCFLFA CYQSCHDEED DDGEEEVKSF EEKEMEKQKL LYQQARLHDR
     GAAEMVLQTI SASKGEMGPM VAATLKLGIA ILNGGNSTVQ QKMLDYLKDK KDVGFFQSLA
     GLMQSCSVLD LNAFERQNKA EGLGMVTEEG SGEKVMQDDE FTCDLFRFLQ LLCEGHNSDF
     QNYLRTQTGN NTTVNIIIST VDYLLRVQES ISDFYWYYSG KDVIDEQGQR NFSKAIQVAK
     QVFNTLTEYI QGPCTGNQQS LAHSRLWDAV VGFLHVFAHM QMKLSQDSSQ IELLKELMDL
     QKDMVVMLLS MLEGNVVNGT IGKQMVDMLV ESSNNVEMIL KFFDMFLKLK DLTSSDAFKE
     YDPDGKGIIS KRDFHKAMES HKHYTQSETE FLLSCAETDE NETLDYEEFV KRFHEPAKDI
     GFNVAVLLTN LSEHMPHDTR LQTFLELSES VLNYFQPFLG RIEIMGSAKR IERVYFEISE
     SSRTQWEKPQ VKESKRQFIF DVVNEGGEKE KMELFVNFCE DTIFEMQLAA QISESDLNER
     SANKEDNEKD KLEEQDPGMG FFSLVTMKSA LVALKYNLMT LMKMLSVKSL KKQMKKVKKM
     TMKDMVMALF SSYWSILMGL LHFACSVFRG FFRIICSLLL GGSLVEGAKK IKVAELLANM
     PDPTQDEVRG EGEEGERKPA ETALPTEDLT DLRTLSEESD LLSDIFGLDL KREGGQYKLI
     PHNPNAGLSD LLSTPSVAPM PEAQEKVQVI ILFICVVCFS SFSYVKGEDG EKEEKAKEDR
     AKQKLRQLHT HRYGEPEIQE SAFWKKIIAY QQKLLNYFAR NFYNMRMLAL FVAFAINFIL
     LFYKVSTSAV TEEKEIPVVS TGENMKLDSL ESDSQRVIAV HYVLEESSGY MEPTLRILAI
     LHTVISFFCI IGYYCLKVPL VIFKREKEVA RKLEFDGLYI TEQPSEDDIK GQWDRLVINT
     QSFPNNYWDK FVKRKVMDKY GEFYGRDRIS ELLGMDKAAL DFSDAREKKK PKKDSSLSAV
     LNSIDVKYQM WKLGVVFTDN SFLYLAWYMT MSVLGHYNNF FFAAHLLDIA MGFKTLRTIL
     SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE DGDMPDMKCD DMLTCYMFHM
     YVGVRAGGGI GDEIEDPAGD EYEIYRIIFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ
     EQVKEDMETK CFICGIGNDY FDTVPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE
     SYVWKMYQER CWEFFPAGDC FRKQYEDQLN
//
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