ID A0A1D5PCD1_CHICK Unreviewed; 428 AA.
AC A0A1D5PCD1;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Flotillin {ECO:0000256|RuleBase:RU366054};
GN Name=FLOT2 {ECO:0000313|Ensembl:ENSGALP00010044859.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010044859.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010044859.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010044859.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterooligomeric complex. {ECO:0000256|RuleBase:RU366054}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU366054}.
CC Endosome {ECO:0000256|RuleBase:RU366054}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC {ECO:0000256|ARBA:ARBA00007161, ECO:0000256|RuleBase:RU366054}.
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DR RefSeq; XP_015151251.1; XM_015295765.1.
DR AlphaFoldDB; A0A1D5PCD1; -.
DR SMR; A0A1D5PCD1; -.
DR Ensembl; ENSGALT00010072458.1; ENSGALP00010044859.1; ENSGALG00010030004.1.
DR VEuPathDB; HostDB:geneid_417579; -.
DR GeneTree; ENSGT00560000077232; -.
DR InParanoid; A0A1D5PCD1; -.
DR Reactome; R-GGA-8849932; Synaptic adhesion-like molecules.
DR Reactome; R-GGA-8980692; RHOA GTPase cycle.
DR Reactome; R-GGA-9013026; RHOB GTPase cycle.
DR Reactome; R-GGA-9013106; RHOC GTPase cycle.
DR Reactome; R-GGA-9696264; RND3 GTPase cycle.
DR Reactome; R-GGA-9696273; RND1 GTPase cycle.
DR Proteomes; UP000000539; Chromosome 19.
DR Bgee; ENSGALG00000031216; Expressed in granulocyte and 12 other cell types or tissues.
DR ExpressionAtlas; A0A1D5PCD1; baseline.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016600; C:flotillin complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0045661; P:regulation of myoblast differentiation; IBA:GO_Central.
DR CDD; cd03399; SPFH_flotillin; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR031905; Flotillin_C.
DR InterPro; IPR027705; Flotillin_fam.
DR PANTHER; PTHR13806:SF46; FLOTILLIN-2; 1.
DR PANTHER; PTHR13806; FLOTILLIN-RELATED; 1.
DR Pfam; PF01145; Band_7; 1.
DR Pfam; PF15975; Flot; 1.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE 1: Evidence at protein level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366054};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A1D5PCD1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT DOMAIN 87..269
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
SQ SEQUENCE 428 AA; 47236 MW; 6A098DABA475017E CRC64;
MGNCHTVGPN EALVVSGGCC GSDVKQYVYG GWAWAWWCIT DTQRLSLEVM TILCRCENIE
TSEGVPLYVT GVAQVKIMTE KELLAVACEQ FLGKNVQDVK NVVLQTLEGH LRSILGTLTV
EQIYQDRDQF AKLVREVAAP DVGRMGIEIL SFTIKDVYDK VDYLSSLGKT QTAAVRRDAD
IGVAEAERDA GIREAECKKE MLDVKFMADT KIADSRRAFE LQKAAFTEEV NIKTAEAQLA
YELQSAREQQ KIRQEEIEIE VVQRKKQIDV EEKEIIRKEK ELIATVKRPA EAEAYRIQQI
AEGEKVRRVL LAQAEAEKIR KIGEAEAFVI EAIGMAEAER MKLKAEALQS YGEAAQLALV
LDALPEIAAK VAAPLSRVDE IVVLSGESGN VTSEVNRLLA EIPASVRAIT GVDLTKIPLI
QKATGAQA
//
