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Database: UniProt
Entry: A0A1D5Q6A8_MACMU
LinkDB: A0A1D5Q6A8_MACMU
Original site: A0A1D5Q6A8_MACMU 
ID   A0A1D5Q6A8_MACMU        Unreviewed;      2610 AA.
AC   A0A1D5Q6A8;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   16-JAN-2019, entry version 16.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSMMUP00000043574};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSMMUP00000043574};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000043574, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000043574, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000043574,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000043574}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000043574};
RG   Ensembl;
RL   Submitted (OCT-2016) to UniProtKB.
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DR   EMBL; JSUE03030713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_014991603.1; XM_015136117.1.
DR   UniGene; Mmu.20461; -.
DR   Ensembl; ENSMMUT00000055273; ENSMMUP00000043574; ENSMMUG00000047729.
DR   GeneID; 718040; -.
DR   KEGG; mcc:718040; -.
DR   CTD; 3710; -.
DR   GeneTree; ENSGT00940000157078; -.
DR   KO; K04960; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000006718; Chromosome 4.
DR   ExpressionAtlas; A0A1D5Q6A8; baseline.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2140   2165       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2177   2195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2207   2227       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2263   2288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2308   2330       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2437   2460       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       52    112       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      113    163       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      171    227       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      234    311       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      317    373       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       29     49       {ECO:0000256|SAM:Coils}.
FT   COILED     2568   2595       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2610 AA;  297493 MW;  7DD90A85E3031322 CRC64;
     MNRYSAQKQY WKAKQTKQDK EKIADVVLLQ KLQHAAQMEQ KQNDTENKKV HGDVVKYGSV
     IQLLHMKSNK YLTVNKRLPA LLEKNAMRVT LDATGNEGSW LFIQPFWKLR SNGDNVVVGD
     KVILNPVNAG QPLHASNYEL SDNAGCKEVN SVNCNTSWKI NLFMQFRDHL EEVLKGGDVV
     RLFHAEQEKF LTCDEYKGRL QVFLRTTLRQ SATSATSSNA LWEVEVVHHD PCRGGAGHWN
     GLYRFKHLAT GNYLAAEENP SYKGDASDPK ATGMGAQGRA GRRNAGEKIK YRLVAVPHGN
     DIASLFELDP TTLQKTDSFV PRNSYVRLRH LCTNTWIQST NVPIDIEEER PIRLMLGTCP
     TKEDKEAFAI VSVPVSEIRD LDFANDASSM LASAVEKLNE GFISQNDRRF VIQLLEDLVF
     FVSDVPNNGQ NVLDIMVTKP NRERQKLMRE QNILKQIFGI LKAPFREKGG EGPLVRLEEL
     SDQKNAPYQH MFRLCYRVLR HSQEDYRKNQ EHIAKQFGMM QSQIGYDILA EDTITALLHN
     NRKLLEKHIT KTEVETFVSL VRKNREPRFL DYLSDLCVSN HIAIPVTQEL ICKCVLDPKN
     SDILIQTELR PVKEMAQSHE YLSIEYSDEE VWLTWTDKNN EHHEKSVRQL AQEARAGNAH
     DENVLSYYRY QLKLFARMCL DRQYLAIDEI SQQLGVDLIF LCMADEMLPF DLRASFCHLM
     LHVHVDRDPQ ELVTPVKFAR LWTEIPTAIT IKDYDSNLNA SRDDKKNKFA NTMEFVEDYL
     NNVVSEAVPF ANEEKNKLTF EVVSLAHNLI YFGFYSFSEL LRLTRTLLGI IDCVQGPPAM
     LQAYEDPGGK NVRRSIQGVG HMMSTMVLSR KQSVFGAPSL PAGASAAEPL DRSKFEENED
     IVVMETKLKI LEILQFILNV RLDYRISYLL SVFKKEFVEV FPMQDSGADG TAPAFDSTTA
     NMNLDRIGEQ AEAMFGVGKT SSMLEVDDEG GRMFLRVLIH LTMHDYAPLV SGALQLLFKH
     FSQRQEAMHT FKQVQLLISA QDVENYKVIK SELDRLRTMV EKSELWVDKK GSGKGEEVEA
     GAAKDKKERP TDEEGFLHPP GEKSSENYQI VKGILERLNK MCGVGEQMRK KQQRLLKNMD
     AHKVMLDLLQ IPYDKGDAKM MEILRYTHQF LQKFCAGNPG NQALLHKHLH LFLTPGLLEA
     ETMQHIFLNN YQLCSEISEP VLQHFVHLLA THGRHVQYLD FLHTVIKAEG KYVKKCQDMI
     MTELTNAGDD VVVFYNDKAS LAHLLDMMKA ARDGVEDHSP LMYHISLVDL LAACAEGKNV
     YTEIKCTSLL PLEDVVSVVT HEDCITEVKM AYVNFVNHCY VDTEVEMKEI YTSNHIWTLF
     ENFTLDMARV CSKREKRVAD PALEKYVLSV VLDTINAFFS SPFSENSTSL QTHQTIVVQL
     LQSTTRLLEC PWLQQQHKGS VEACIRTLAM VAKGRAISLP MDLDAHISSM LSSGASCAAA
     AQRNASSYKA TTRAFPRVTP TANQWDYKNI IEKLQDIITA LEERLKPLVQ AELSVLVDVL
     HWPELLFLEG SEAYQRCESG GFLSKLIQHT KDLMESEEKL CIKVLRTLQQ MLLKKTKYGD
     RGNQLRKMLL QNYLQNRKST SRGDLPDPMG TGLDPDWSAI AATQCRLDKE GATKLVCDLI
     TSTKNEKIFQ ESIGLAIRLL DGGNTEIQKS FHNLMMSDKK SERFFKVLHD RMKRAQQETK
     STVAVNMNDL GSQPHEDREP VDPTTKGRVA SFSIPGSSSR YSLGPSLRRG HEVSERVQSN
     EMGTSVLIMQ PILRFLQLLC ENHNRDLQNF LRCQNNKTNY NLVCETLQFL DIMCGSTTGG
     LGLLGLYINE DNVGLVIQTL ETLTEYCQGP CHENQTCIVT HESNGIDIIT ALILNDISPL
     CKYRMDLVLQ LKDNASKLLL ALMESRHDSE NAERILISLR PQELVDVIKK AYLQEEEREN
     SEVSPREVGH NIYILALQLS RHNKQLQHLL KPVKRIQEEE AEGISSMLSL NNKQLSQMLK
     SSVPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP GICQFLTEET KHRLFTTTEQ
     DEQGSKVSDF FDQSSFLHNE MEWQRKLRSM PLIYWFSRRM TLWGSISFNL AVFINIIIAF
     FYPYMEGAST GVLDSPLISL LFWILICFSI AALFTKRYSI RPLIVALILR SIYYLGIGPT
     LNILGALNLT NKIVFVVSFV GNRGTFIRGY KAMVMDMEFL YHVGYILTSV LGLFAHELFY
     SILLFDLIYR EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL KDDFILEVDR
     LPNNHSTASP LGMPHGAAAF VDTCSGDKMD CVSGVSVPEV LEEDGELDST ERACDTLLMC
     IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF FIVIIIVLNL IFGVIIDTFA
     DLRSEKQKKE EILKTTCFIC GLERDKFDNK TVSFEEHIKL EHNMWNYLYF IVLVRVKNKT
     DYTGPESYVA QMIKNKNLDW FPRMRAMSLV SNEGEGEQNE IRILQDKLNS TMKLVSHLTA
     QLNELKEQMT EQRKRRQRLG FVDVQNCMSR
//
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