ID A0A1D5Q6U1_MACMU Unreviewed; 709 AA.
AC A0A1D5Q6U1;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Sorbin and SH3 domain containing 2 {ECO:0000313|Ensembl:ENSMMUP00000043757.2};
GN Name=SORBS2 {ECO:0000313|Ensembl:ENSMMUP00000043757.2,
GN ECO:0000313|VGNC:VGNC:77767};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000043757.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000043757.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000043757.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A1D5Q6U1; -.
DR SMR; A0A1D5Q6U1; -.
DR Ensembl; ENSMMUT00000061693.2; ENSMMUP00000043757.2; ENSMMUG00000015733.4.
DR VEuPathDB; HostDB:ENSMMUG00000015733; -.
DR VGNC; VGNC:77767; SORBS2.
DR GeneTree; ENSGT00940000157056; -.
DR Proteomes; UP000006718; Chromosome 5.
DR Bgee; ENSMMUG00000015733; Expressed in heart and 21 other cell types or tissues.
DR ExpressionAtlas; A0A1D5Q6U1; baseline.
DR CDD; cd11923; SH3_Sorbs2_2; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR PANTHER; PTHR14167:SF56; DREBRIN-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF02208; Sorb; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 183..244
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 472..531
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 547..608
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 650..709
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 31..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..299
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 78935 MW; 48621C7818A94206 CRC64;
MKAWRSYNDG NQETLNGDAT YSSLAAKGFR SVRPNLQDKR SPTQIAPLSG QDPESHKRLP
ELSPETAKIP LQQERQKSAV AVASQSSGCR LGNQNLPASV LESQITVNGN SGGAVSPMSY
YQRPFSPSAY SLPASLNSSI VMQHGTSLDS TETYPQHAHS LDGTTSSSVP LYRSSEEEKR
VTVIKAPHYP GIGPVDESGI PTAIRTTVDR PKDWYKTMFK QIHMVHKPDD DTDMYHTPYT
YNAGLYNPPY SAQSHPAAKT QTYRPLSKSH SDNSTNAFKD ASSPVPPPHV PPPVPPLRPR
DRSSTEKHDW DPPDRKVDTR KFRSEPRSIF EYEPGKSSIL QHERPPPKKP LDYVQDHSSG
VFNEASLYQS SIDRSLERPM SSASMASDFR KRRKSEPAVG PPRGLGDQSV SRTSPGRADL
PGSSATLTKS FTSSSPSSPS RAKGRESPRS YSSTLTDTGR STPRERRGTP EKEKLPAKAV
YDFKAQTSKE LSFKKGDTVY ILRKIDQNWY EGEHHGRVGI FPISYVEKLT PPEKAQPARP
PPPAQPGEIG EAIAKYNFSA DTNVELSLRK GDRVILLKRV DQNWYEGKIP GTNRQGIFPV
SYVEVVKKNT KGAEDYPDPP MPHSYSSDRI HSLSSNKPQR PVFTHENIQG GGEPFQALYN
YTPRNEDELE LRESDVIDVM EKCDDGWFVG TSRRTKFFGT FPGNYVKRL
//
