ID A0A1D5Q7V0_MACMU Unreviewed; 1449 AA.
AC A0A1D5Q7V0;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=NLR family pyrin domain containing 1 {ECO:0000313|Ensembl:ENSMMUP00000044116.2};
GN Name=NLRP1 {ECO:0000313|Ensembl:ENSMMUP00000044116.2,
GN ECO:0000313|VGNC:VGNC:99189};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000044116.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000044116.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000044116.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR SMR; A0A1D5Q7V0; -.
DR Ensembl; ENSMMUT00000061013.2; ENSMMUP00000044116.2; ENSMMUG00000030453.3.
DR VEuPathDB; HostDB:ENSMMUG00000030453; -.
DR VGNC; VGNC:99189; NLRP1.
DR eggNOG; ENOG502S4A4; Eukaryota.
DR GeneTree; ENSGT00940000162176; -.
DR Proteomes; UP000006718; Chromosome 16.
DR Bgee; ENSMMUG00000030453; Expressed in spleen and 11 other cell types or tissues.
DR ExpressionAtlas; A0A1D5Q7V0; baseline.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 332..641
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1055..1340
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1356..1439
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 94..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1449 AA; 163038 MW; D286A728C53D3F08 CRC64;
MAGGAWGRLA CYLELLKKEE LKEFQLLFAS KVHSSGSSGE TPARPEKTSG MEVASYLVAQ
YGEQRAWDLA LRTWEQMGLW SLCTQAREGA GYSPSFPYSP SEPHLGSPSQ PTSTAVLRPW
NRELPAECTQ GSERRVLRQL PDTSGRRWRE ISSSLLYQAL PSSPDFESPS QESPNAPTST
AVLASWGSPP QPSLAPREQE APGTQWPLDE MSGNYYTGIR EREREESEKG RPPWEAAVGT
PPQVHTSLQP HHHPWEPSAR ESLCSTWSWK NEDLNQNFTQ LLLLQRPHPR SHKPLVKGSW
PHDAEEDVEE DRGRLIEIRD LFGPGLDIQE PHVVILQGAA GIGKSTLARQ VREAWGRGQL
YGDRFQHVFY FSCRELAQCK VVSLAELIGK DWTAAQAPIR QILSRPERLL FILDGVDEPR
WVLQESSSEL CLHWSQPQPA GALLGSLLGK TILPEASFLI TARTTALQNL IPSLEQARWV
EVLGFSESSR REYFYKYFTD ERQAIRAFGL IKSNKELWAL CLVPWVSWLA CTCLMEQMKR
KEELTLTSKT TTTLCLHYLS QALQAQPLGP QLGDICSLAA EGIWQKKTLF SRDDLRKHEL
DGAIISTLLK MGILQEHPIP LSYSFIHLCF QEFFAAMSYA LEDKKGRGKH ANCIIDLEKL
LEAYGTHGLF GAPTTRFLLG LLSDEGKRAM ENIFNCRLSQ GRNLMQWVPS LRPLLQPHSL
DFLHCLYETQ NKTFLTQMMA DFQEMGMCVE TDMELLVCTF CIQFCRHVKK LQLIEGRQHR
PAWSPTGIVL FRWVPVTDAY WEILFSVFKV TRNLKELDLS GNSLSHSAVK SLCKTLRRPC
CLLETLRLAS CGLTAEDCKD LASGLRVNQN LTVLDLSFNV LTDAGARHLC QRLSWPCCTL
QRLQLVSCGL TSGCCQDLAS VLSASPILME LDLQQNNLGD TGVRLLCEGL RHPACQLTRL
GLDQTTLSDE MRQELRALEQ KKPELLIFSR WRQGKKTESS HVAQADPKPL DWSNPPATAS
QKGSSPEVEQ VEPLCLPSPA SLGDQDTPLG TDDDFWGPTG PVATEVVDKE RSLYRVHFPV
AGSYRWPNTG LCFVVREAVT TEIEFCVWDQ FLGEINPQHS WMVAGPLLDI KAEPGAVEAV
HLPHFVALQG GHVDTSLFQV AHFKEEGMLL EKPARVELHH IVLENPSFSP LGVLLKVIHS
TLRFFPVNSL VLLYHRLHPE EVTFHLYLIP SDCSIRKAID DEETKFQFVR IHKPPPLTPL
YMGCRYTVSG SGSGMLEILP KELELCYRSP GEAQLFSEFY VGHLGSGIRL QMKDKKDETV
VWEALVKPGD LAPAATLVPP APIALPSPLD APGLLHFVDQ YREQLVARVT SVEAVLDKLH
GQVLSQEQYE RVLAEDTRPS QMRKLFSLSQ SWDRRCKDQL YQALKETHPH LIMELWEKGS
KKGLLPLCS
//
