ID A0A1D5QA58_MACMU Unreviewed; 1069 AA.
AC A0A1D5QA58;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Partner and localizer of BRCA2 {ECO:0000313|Ensembl:ENSMMUP00000044926.2};
GN Name=PALB2 {ECO:0000313|Ensembl:ENSMMUP00000044926.2,
GN ECO:0000313|VGNC:VGNC:108148};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000044926.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000044926.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000044926.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A1D5QA58; -.
DR Ensembl; ENSMMUT00000066245.2; ENSMMUP00000044926.2; ENSMMUG00000017304.4.
DR VEuPathDB; HostDB:ENSMMUG00000017304; -.
DR VGNC; VGNC:108148; PALB2.
DR GeneTree; ENSGT00390000014423; -.
DR Proteomes; UP000006718; Chromosome 20.
DR Bgee; ENSMMUG00000017304; Expressed in ileum and 22 other cell types or tissues.
DR ExpressionAtlas; A0A1D5QA58; baseline.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR042417; PALB2.
DR InterPro; IPR031920; PALB2_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14662; PARTNER AND LOCALIZER OF BRCA2; 1.
DR PANTHER; PTHR14662:SF2; PARTNER AND LOCALIZER OF BRCA2; 1.
DR Pfam; PF16756; PALB2_WD40; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 838..1065
FT /note="Partner and localiser of BRCA2 WD40"
FT /evidence="ECO:0000259|Pfam:PF16756"
FT REGION 49..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 14..41
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 57..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 118616 MW; 34F379A08BF418FD CRC64;
MEEPPGKPLS CEEKEKLKEK LAFLKREYSK TLARLQRAQR AEKIKHSIKK TVEEQDYLSQ
QELSPQLNHS EPKNKICVYD KLHIKTHLDE ETGERTSVTL DVGPESFNPG DGPGGLPIHG
TDDTQEHFPH RVSDPDGEQK QKLPGRRKKQ QKRTFISQER DCVFGTDSLR LSGKRLKEQE
ETSSKNPTRS PVTEIRTHLL SLKSELPDSP EPVTETNEDS IFIPPTAQPE KGVDTLLRRP
DFTRATTVPL QTPTDSSSSQ HLEHIPPKGS SELTTHCLKN IRFTSPVSLE AQGKKVTIPT
DNLVVNKAVS KSGQLPTSSN LEADISCSLN ELTHDNLPAN ENQNLEQNQT EKSLKSPGDA
LDGRNENLQE NEILSQPKSL SLEATSLLAA EKHSCTMLEG LLFPAEYYVR TTRSMSNCQR
KVALEAVIQS HLDVKKKGFK NKNKDASKNL NLSNEETDQS EIRMSDTCTG QPSSRTSQKL
LSLTKVSSPA EPTEDNDLSR KAVAQAPSRR YRGKRKSACT PASDHCEPLL PACNPSVINR
SKEEVTSHKY QNKKAVIRVK GKKSHQKEDS LSWSNSAYLS LDDDAFTASF HKDGMLSLKQ
LLSFLSITDF QLPDEDFGCL KLEKLKSCSE KPVEPFESNM FGERRLKEGN CIFPEELSPK
RMDTEMEDLE EDLVVLPGKS HPKRPNPQSQ HTKTGLSSSI LLYTPLNTVA LDDNDRPAAD
MCSPLFPILG TTPAFGPQGS YEKASTEVAG QTCRTPQLAH LKDSVCLASD SKQFDRSSSP
AKPHTTLQVS GRQGQPTCDC DSALPGTPPP IESFTFKVNQ LCGNTCQELH KHSIEQTETA
ELPASDSINP GNLQLVSKLK NPSGSCSVDV SAMFWERAGC KEPCIITACE DVVSLWKALD
AWQWEKLYTW HFTEVPVLQI VPVPDVYNLV CVALGNLEIR EIRALLCSSD DESEKQVLLK
SGNIKAVLGL TKRRLVSSSG TLSDQQVEVM TFAEDGGGKE NQFLMPPEET ILTFAEVQGM
QEALLGTTVM NNIVIWNLKT GQLLKKMHID DSYQASVCHK AYSEMVPGR
//
