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Database: UniProt
Entry: A0A1D5QB17_MACMU
LinkDB: A0A1D5QB17_MACMU
Original site: A0A1D5QB17_MACMU 
ID   A0A1D5QB17_MACMU        Unreviewed;      1691 AA.
AC   A0A1D5QB17;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 2.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Roundabout guidance receptor 1 {ECO:0000313|Ensembl:ENSMMUP00000045235.2};
GN   Name=ROBO1 {ECO:0000313|Ensembl:ENSMMUP00000045235.2,
GN   ECO:0000313|VGNC:VGNC:76713};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000045235.2, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000045235.2, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000045235.2,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA   Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA   Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA   Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA   Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA   Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA   Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA   Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA   Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA   Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA   Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA   Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA   Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA   Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA   Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA   Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA   Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA   Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA   Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA   Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA   Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA   Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA   Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA   Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA   Kuhn R.M., Smith K.E., Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000045235.2}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000045235.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   STRING; 9544.ENSMMUP00000045235; -.
DR   Ensembl; ENSMMUT00000056421.2; ENSMMUP00000045235.2; ENSMMUG00000002327.4.
DR   VEuPathDB; HostDB:ENSMMUG00000002327; -.
DR   VGNC; VGNC:76713; ROBO1.
DR   GeneTree; ENSGT00940000154477; -.
DR   InParanoid; A0A1D5QB17; -.
DR   Proteomes; UP000006718; Chromosome 2.
DR   Bgee; ENSMMUG00000002327; Expressed in Ammon's horn and 22 other cell types or tissues.
DR   ExpressionAtlas; A0A1D5QB17; baseline.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0008046; F:axon guidance receptor activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0030275; F:LRR domain binding; IEA:Ensembl.
DR   GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro.
DR   GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR   GO; GO:0021836; P:chemorepulsion involved in postnatal olfactory bulb interneuron migration; IEA:Ensembl.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR   GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0070100; P:negative regulation of chemokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0050925; P:negative regulation of negative chemotaxis; IEA:Ensembl.
DR   GO; GO:0050772; P:positive regulation of axonogenesis; IEA:Ensembl.
DR   GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
DR   GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:1900748; P:positive regulation of vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR   GO; GO:0035385; P:Roundabout signaling pathway; IEA:Ensembl.
DR   CDD; cd00063; FN3; 3.
DR   CDD; cd07693; IgC_1_Robo; 1.
DR   CDD; cd05724; IgI_2_Robo; 1.
DR   CDD; cd05725; IgI_3_Robo; 1.
DR   CDD; cd05726; IgI_4_Robo; 1.
DR   CDD; cd20952; IgI_5_Robo; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR032986; Robo1_Ig-like3.
DR   PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR   PANTHER; PTHR44170:SF9; ROUNDABOUT HOMOLOG 2; 1.
DR   Pfam; PF00041; fn3; 3.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF13927; Ig_3; 3.
DR   SMART; SM00060; FN3; 3.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 5.
DR   SMART; SM00406; IGv; 3.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   SUPFAM; SSF48726; Immunoglobulin; 5.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          101..197
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          203..290
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          295..379
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          384..479
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          488..574
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          596..690
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          709..806
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          811..907
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          62..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1160..1370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1385..1430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1453..1659
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1166..1199
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1284..1304
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1325..1341
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1390..1430
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1471..1488
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1549..1572
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1587..1610
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1623..1654
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1691 AA;  185196 MW;  0ACC19A17F22FB48 CRC64;
     MMLRPSQGLV YRRRGKDEVC CVLSLCVFLS HVDLLVSGHA VIEMATTVTT VTPSAALVLF
     PTDPEDLERG KDNGTPIPTS ENDDNSLGYT GSRLRQEDFP PRIVEHPSDL IVSKGEPATL
     NCKAEGRPTP TIEWYKGGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRK SRPDEGVYVC
     VARNYLGEAV SHNASLEVAI LRDDFRQNPS DVMVAVGEPA VMECQPPRGH PEPTISWKKD
     GSPLDDKDER ITIRGGKLMI TYTRKSDAGK YVCVGTNMVG ERESEVAELT VLERPSFVKR
     PSNLAVTVDD SAEFKCEARG DPVPTVRWRK DDGELPKSRY EIRDDHTLKI RKVMAGDMGS
     YTCVAENMVG KAEASATLTV QEPPHFVVKP RDQVVALGRT VTFQCEATGN PQPAIFWRRE
     GSQNLLFSYQ PPQSSSRFSV SQTGDLTITN VQRSDVGYYI CQTLNVAGSI ITKAYLEVTD
     VIADRPPPVI RQGPVNQTVA VDGTLVLSCV ATGSPVPTIL WRKDGVLVST QDSRIKQLEN
     GVLQIRYAKL GDTGRYTCIA STPSGEATWS AYIEVQEFGV PVQPPRPTDP NLIPSAPSKP
     EVTDVSRNTV TLSWQPNLNS GATPTSYIIE AFSHASGSSW QTVAENVKTE TFAIKGLKPN
     AIYLFLVRAA NAYGISDPSQ ISDPVKTQDV PPTSQGVDHK QVQRELGNVV LHLHNPTILS
     SSSIEVHWTV DQQSQYIQGY KILYRPSGAN HGESDWLVFE VRTPTKNSVV IPDLRKGVNY
     EIKARPFFNE FQGADSEIKF AKTLEEAPSA PPQGVTVSKN DGNGTAILVS WQPPPEGTQN
     GMVQEYKVWC LGNETRYHIN KTVDGSTFSV VIPFLVPGIR YSVEVAASTG AGPGVKSEPQ
     FIQLDSHGNP VSPEDQVSLA QQISDVVKQP AFIAGIGAAC WIILMVFSIW LYRHRKKRNG
     LTSTYAGIRK VPSFTFTPTV TYQRGGEAVS SGGRPGLLNI SEPATQPWLA DTWPNTGNNH
     NDCSINCCTA GNGNSDSNLT TYSRPADCIA NYNNQLDNKQ TNLMLPESTV YGDVDLSNKI
     NEMKTFNSPN LKDGRFVNPS GQPTPYATTQ LIQSNLSNNM NNGSGDSGEK HWKPLGQQKQ
     EVAPVQYNIM EQNKLNKDYR ANDTIPPTIP YNQSYDQNTG GSYNSSDRGS STSGSQGHKK
     GARTPKVPKQ GGMNWADLLP PPPAHPPPHS NSEEYNISVD ESYDQEMPCP VPPARMYLQQ
     DELEEEEDER GPTPPVRGAA SSPAAVSYSH QSTATLTPSP QEELQPMLQD CPEETGHMQH
     PPDRRRQPVS PPPPPRPISP PHTYGYISGP LVSDMDTDAP EEEEDEADME VAKMQTRRLL
     LRGLEQTPAS SVGDLESSVT GSMINGWGSA SEEDNISSGR SSVSSSDGSF FTDADFAQAV
     AAAAEYAGLK VARRQVQDAA GRRHFHASQC PRPTSPVSTD SNMSAAIMQK TRPAKKPKHQ
     PGHLRREAYT DDLPPPPVPP PAIKSPTVQS KTQLEVRPVV VPKLPSIDAR TERSSDRKGS
     SYKGREVLDG RPVVDVRTNP GDPREAQEQQ NDGKGRGNKG AKRDLLPAKT HLVQEDILPY
     CRPTFPTSNN PRDPSSSSSM SSRGSGSRQR EQANVGRRNI AEMQVLGGYE RGEDNNEELE
     VSIIFSQVYR C
//
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