ID A0A1D5QB17_MACMU Unreviewed; 1691 AA.
AC A0A1D5QB17;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Roundabout guidance receptor 1 {ECO:0000313|Ensembl:ENSMMUP00000045235.2};
GN Name=ROBO1 {ECO:0000313|Ensembl:ENSMMUP00000045235.2,
GN ECO:0000313|VGNC:VGNC:76713};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000045235.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Ensembl:ENSMMUP00000045235.2, ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000045235.2,
RC ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000045235.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000045235.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9544.ENSMMUP00000045235; -.
DR Ensembl; ENSMMUT00000056421.2; ENSMMUP00000045235.2; ENSMMUG00000002327.4.
DR VEuPathDB; HostDB:ENSMMUG00000002327; -.
DR VGNC; VGNC:76713; ROBO1.
DR GeneTree; ENSGT00940000154477; -.
DR InParanoid; A0A1D5QB17; -.
DR Proteomes; UP000006718; Chromosome 2.
DR Bgee; ENSMMUG00000002327; Expressed in Ammon's horn and 22 other cell types or tissues.
DR ExpressionAtlas; A0A1D5QB17; baseline.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0008046; F:axon guidance receptor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030275; F:LRR domain binding; IEA:Ensembl.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0021836; P:chemorepulsion involved in postnatal olfactory bulb interneuron migration; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0070100; P:negative regulation of chemokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0050925; P:negative regulation of negative chemotaxis; IEA:Ensembl.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IEA:Ensembl.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1900748; P:positive regulation of vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:Ensembl.
DR CDD; cd00063; FN3; 3.
DR CDD; cd07693; IgC_1_Robo; 1.
DR CDD; cd05724; IgI_2_Robo; 1.
DR CDD; cd05725; IgI_3_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR032986; Robo1_Ig-like3.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF9; ROUNDABOUT HOMOLOG 2; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 101..197
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 203..290
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 295..379
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 384..479
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 488..574
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 596..690
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 709..806
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 811..907
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 62..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1160..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1385..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1453..1659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1341
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1390..1430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1549..1572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1587..1610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1623..1654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1691 AA; 185196 MW; 0ACC19A17F22FB48 CRC64;
MMLRPSQGLV YRRRGKDEVC CVLSLCVFLS HVDLLVSGHA VIEMATTVTT VTPSAALVLF
PTDPEDLERG KDNGTPIPTS ENDDNSLGYT GSRLRQEDFP PRIVEHPSDL IVSKGEPATL
NCKAEGRPTP TIEWYKGGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRK SRPDEGVYVC
VARNYLGEAV SHNASLEVAI LRDDFRQNPS DVMVAVGEPA VMECQPPRGH PEPTISWKKD
GSPLDDKDER ITIRGGKLMI TYTRKSDAGK YVCVGTNMVG ERESEVAELT VLERPSFVKR
PSNLAVTVDD SAEFKCEARG DPVPTVRWRK DDGELPKSRY EIRDDHTLKI RKVMAGDMGS
YTCVAENMVG KAEASATLTV QEPPHFVVKP RDQVVALGRT VTFQCEATGN PQPAIFWRRE
GSQNLLFSYQ PPQSSSRFSV SQTGDLTITN VQRSDVGYYI CQTLNVAGSI ITKAYLEVTD
VIADRPPPVI RQGPVNQTVA VDGTLVLSCV ATGSPVPTIL WRKDGVLVST QDSRIKQLEN
GVLQIRYAKL GDTGRYTCIA STPSGEATWS AYIEVQEFGV PVQPPRPTDP NLIPSAPSKP
EVTDVSRNTV TLSWQPNLNS GATPTSYIIE AFSHASGSSW QTVAENVKTE TFAIKGLKPN
AIYLFLVRAA NAYGISDPSQ ISDPVKTQDV PPTSQGVDHK QVQRELGNVV LHLHNPTILS
SSSIEVHWTV DQQSQYIQGY KILYRPSGAN HGESDWLVFE VRTPTKNSVV IPDLRKGVNY
EIKARPFFNE FQGADSEIKF AKTLEEAPSA PPQGVTVSKN DGNGTAILVS WQPPPEGTQN
GMVQEYKVWC LGNETRYHIN KTVDGSTFSV VIPFLVPGIR YSVEVAASTG AGPGVKSEPQ
FIQLDSHGNP VSPEDQVSLA QQISDVVKQP AFIAGIGAAC WIILMVFSIW LYRHRKKRNG
LTSTYAGIRK VPSFTFTPTV TYQRGGEAVS SGGRPGLLNI SEPATQPWLA DTWPNTGNNH
NDCSINCCTA GNGNSDSNLT TYSRPADCIA NYNNQLDNKQ TNLMLPESTV YGDVDLSNKI
NEMKTFNSPN LKDGRFVNPS GQPTPYATTQ LIQSNLSNNM NNGSGDSGEK HWKPLGQQKQ
EVAPVQYNIM EQNKLNKDYR ANDTIPPTIP YNQSYDQNTG GSYNSSDRGS STSGSQGHKK
GARTPKVPKQ GGMNWADLLP PPPAHPPPHS NSEEYNISVD ESYDQEMPCP VPPARMYLQQ
DELEEEEDER GPTPPVRGAA SSPAAVSYSH QSTATLTPSP QEELQPMLQD CPEETGHMQH
PPDRRRQPVS PPPPPRPISP PHTYGYISGP LVSDMDTDAP EEEEDEADME VAKMQTRRLL
LRGLEQTPAS SVGDLESSVT GSMINGWGSA SEEDNISSGR SSVSSSDGSF FTDADFAQAV
AAAAEYAGLK VARRQVQDAA GRRHFHASQC PRPTSPVSTD SNMSAAIMQK TRPAKKPKHQ
PGHLRREAYT DDLPPPPVPP PAIKSPTVQS KTQLEVRPVV VPKLPSIDAR TERSSDRKGS
SYKGREVLDG RPVVDVRTNP GDPREAQEQQ NDGKGRGNKG AKRDLLPAKT HLVQEDILPY
CRPTFPTSNN PRDPSSSSSM SSRGSGSRQR EQANVGRRNI AEMQVLGGYE RGEDNNEELE
VSIIFSQVYR C
//