ID A0A1D5QCJ7_MACMU Unreviewed; 755 AA.
AC A0A1D5QCJ7;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Transcription factor RFX3 {ECO:0000256|ARBA:ARBA00040859};
DE AltName: Full=Regulatory factor X 3 {ECO:0000256|ARBA:ARBA00042137};
GN Name=RFX3 {ECO:0000313|Ensembl:ENSMMUP00000045766.2,
GN ECO:0000313|VGNC:VGNC:76908};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000045766.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000045766.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000045766.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A1D5QCJ7; -.
DR SMR; A0A1D5QCJ7; -.
DR Ensembl; ENSMMUT00000072285.2; ENSMMUP00000045766.2; ENSMMUG00000000802.4.
DR VEuPathDB; HostDB:ENSMMUG00000000802; -.
DR VGNC; VGNC:76908; RFX3.
DR eggNOG; KOG3712; Eukaryota.
DR GeneTree; ENSGT01050000244879; -.
DR Proteomes; UP000006718; Chromosome 15.
DR Bgee; ENSMMUG00000000802; Expressed in spermatid and 21 other cell types or tissues.
DR ExpressionAtlas; A0A1D5QCJ7; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR007668; RFX1_trans_act.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR PANTHER; PTHR12619:SF20; TRANSCRIPTION FACTOR RFX3; 1.
DR Pfam; PF04589; RFX1_trans_act; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 189..264
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
FT REGION 669..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 84203 MW; F20C96253277B52B CRC64;
MNGETIMQTS ETGSDTGSTV TLQTSVASQA AVPTQVVQQV PVQQQVQQVQ TVQQVQHVYP
AQVQYVEGSD TVYTNGAIRT TTYPYTETQM YSQNTGGNYF DTQGSSAQVT TVVSSHSMVG
TGGIQMGVTG GQLISSSGGT YLIGNSMENS GHSVTHTTRA SPATIEMAIE TLQKSDGLST
HRSSLLNSHL QWLLDNYETA EGVSLPRSTL YNHYLRHCQE HKLDPVNAAS FGKLIRSIFM
GLRTRRLGTR GNSKYHYYGI RVKPDSPLNR LQEDMQYMAM RQQPMQQKQR YKPMQKVDGV
ADGFTGSGQQ TGTSVEQTVI AQSQHHQQFL DASRALPEFG EVEISSLPDG TTFEDIKSLQ
SLYREHCEAI LDVVVNLQFS LIEKLWQTFW RYSPSTPTDG TTITESSNLS EIESRLPKAK
LITLCKHESI LKWMCNCDHG MYQALVEILI PDVLRPIPSA LTQAIRNFAK SLEGWLSNAM
NNIPQRMIQT KVAAVSAFAQ TLRRYTSLNH LAQAARAVLQ NTSQINQMLN DLNRVDFANV
QEQASWVCQC DDNMVQRLET DFKMTLQQQS TLEQWAAWLD NVMMQALKPY EGRPSFPKAA
RQFLLKWSFY SSMVIRDLTL RSAASFGSFH LIRLLYDEYM FYLVEHRVAQ ATGETPIAVM
GEFGDLNAVS PGNLDKDEGS EVESEMDEEL DDSSEPQAKR EKTELSQAFP VGCMQPVLET
GVQPSLLNPI HSEHIVTSTQ TIRQCSATGN TYTAV
//
