ID A0A1D5QES0_MACMU Unreviewed; 2643 AA.
AC A0A1D5QES0;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Thyroglobulin {ECO:0000256|ARBA:ARBA00017326};
GN Name=TG {ECO:0000313|Ensembl:ENSMMUP00000046539.2,
GN ECO:0000313|VGNC:VGNC:99476};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000046539.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000046539.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000046539.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR SMR; A0A1D5QES0; -.
DR STRING; 9544.ENSMMUP00000046539; -.
DR ESTHER; macmu-g7n054; Thyroglobulin.
DR Ensembl; ENSMMUT00000064036.2; ENSMMUP00000046539.2; ENSMMUG00000041378.2.
DR VEuPathDB; HostDB:ENSMMUG00000041378; -.
DR VGNC; VGNC:99476; TG.
DR eggNOG; KOG1214; Eukaryota.
DR GeneTree; ENSGT00940000159300; -.
DR InParanoid; A0A1D5QES0; -.
DR OMA; IQCDGPP; -.
DR Proteomes; UP000006718; Chromosome 8.
DR Bgee; ENSMMUG00000041378; Expressed in fibroblast and 7 other cell types or tissues.
DR ExpressionAtlas; A0A1D5QES0; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0015705; P:iodide transport; IEA:Ensembl.
DR GO; GO:0031641; P:regulation of myelination; IEA:Ensembl.
DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR GO; GO:0006590; P:thyroid hormone generation; IBA:GO_Central.
DR CDD; cd00191; TY; 7.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 9.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR14093; HLA CLASS II GAMMA CHAIN; 1.
DR PANTHER; PTHR14093:SF19; THYROGLOBULIN; 1.
DR Pfam; PF00135; COesterase; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF00086; Thyroglobulin_1; 9.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00211; TY; 9.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 10.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 5.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 10.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Iodination {ECO:0000256|ARBA:ARBA00022653};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW Thyroid hormone {ECO:0000256|ARBA:ARBA00022920};
KW Thyroid hormones biosynthesis {ECO:0000256|ARBA:ARBA00022534}.
FT DOMAIN 1..34
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 35..119
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 172..232
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 479..532
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 533..600
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 601..795
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 876..947
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 948..1019
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 1020..1084
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 1386..1440
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 1704..1726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2603..2643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 5..12
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 14..34
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 38..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 212..232
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 512..532
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 916..923
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 1055..1062
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 1064..1084
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 2643 AA; 290656 MW; 5CDBA2DF30E6F09F CRC64;
MPVQCDVQQV QCWCVDAEGM EVYGTRQPGR PKRCPRSCEI RNRRLLHGVG DKSPPQCSAE
GEFMPVQCKF VNTTDMMIFD LVHSYNRFPD AFVTFNSFQR RFPEVSGYCH CADSQGRELA
ETGLELLLDE IYDTIFAGLD LPSTFTETTL YRILQRRFLA VQSVISGRFR CPTKCEVERF
TATSFGHPYV PSCRRNGDYQ AVQCQTEGPC WCVDVQGKEI HGTRQQGEPP SCAEGRSCAS
KRQQALSRLY FGTSGYFSQH DLFSSPEKRW ASPRVARFAT SCPPTIKELF VDSGLLRPMV
EGQSQQFSVS ESLLKEAIRA IFPSRGLARL ALQFTTNPKR LQQNLFGGKF LVNLGQFNLS
GALGTRGTFN FSQFFQQLGL ASFSNGGRLE DLAKPVSVGL DSNSSTGTPE AAKKDVAMNK
PIVGGFGFEI NLQENQNALK FLASLLELPE FLLFLQHAIS VPEDVARDLG DVMETVLRSQ
TCEQTPERLF VPSCTTEGSY EDVQCFAGEC WCVDSWGKEL PSSRVRGGQP RCPTDCEKQR
ARMQSLMGSQ PAGSSLFVPA CTSEGYFLPV QCFNSECYCV DAEGQAIPGT RSAMGKPKKC
PTPCQLQAEQ AFLRTVQALL PNSSMLPTLS NTYIPQCSAD GQWRQVQCDG PPEQVFEWYQ
RWEAQNKGQE LMPAELLVKI MSYREAASGN FGLFIQSLYE AGQQGVFPVL SQYPSLQDVP
LAALEGNRSQ SRENVLLDPY LFWQILNGQL SRYPGPYSDF STPLAHFDLR NCWCVDEAGQ
ELEGTRAEPS KLPTCPGSCE EAKLLVLQFI RETEEIVSAS NSSRFPLGES FLVAKGIRLR
NEDLGLPPLF PPREALAEQF LRGSDYAIRL AAQSTLSFYQ RRRFSLDDSA GASALLQLGP
YVPQCDAFGS WEPVQCHTGT GHCWCVDEKG GFIPASLTAR SLQIPQCPTT CEKSRTSGLL
SSWKQARSQG NSSPKDLFIP ACLETGEYAR LQASEAGTWC VDPASGEELL PGSNSSAQCP
SLCNVLKSGV LSRRVSSGYV PACREEDGGF SPVQCDQAQG SCWCVTDSGE EVPETRVAGS
QPACESPRCP LPFNTLEVVG GTILCETASG PTGAAIQQCQ LLCRQGSRSV FPRGPLICSL
ESRRWESQLP QPRACQRPQL WQTIQTQGHF QLQLPPGKMC SADYAGLLQA FQVFILDELT
ARGFCQIQVK TFGTLVSVPV CDNSSVQVGC LTREYLGVNV TWKSRLEDIP VASLPDLHDI
ERALVGKDLL GRFTDLIQSG SFQLHLDSKT FPADTTIRFL QGDHFGTSPR TWFGCLEGFY
QVLTSEASQD GLGCVKCPEG SYSQDEECIP CPVGFYQEQA GSLACVPCPA GRMTISAGAF
SQTHCVTDCQ GNEAGLQCDQ NGEYRASQRD RGSGKAFCVD GEGWRLPWSE TEAPLEDSQC
LMMQKFEKAA ESKVIFDANA PVAVRSKVPD SEFPVMQCLT DCAEDEACSF LTVSMTEPEV
SCDFYAWTSD NVACMTSDQK QDALGNSKAT SFGSLRCQVK VRSRGQDSPA VYLKKGQGST
TTLQKSFEPT GFQNMLSGLY NPIVFSASGA NLTDAHLFCL LACDRDLCCD GFVLTQVQGV
AIICGLLSSP NVLLCNVKDW MDPSEARANA TCPGVTYDQE SRQVTLHLGG QEFIKSLTPL
EGTQDTFTNF QQVYLWKDSD MGSRPESMGC RKDTVPRPAS PTETGLTTDL FSPVDLDQVI
VNGNRSLPSQ KHWLFKHLFS AQQANLWCLS RCVQEHSFCQ FAEITESASL YFTCTLYPEA
QVCDDILESN AQGCRLILPQ RPKALFQKKV ILEDKVKNFY TRLPFQKLMG ISIRNKVPMS
EKSISNGFFE CERRCDADPC CTGFGFLNVS QLKGGEVTCL TLNSLGLQMC SEENGGAWRI
LDCGSPDIEV HTYPFGWYQK PIAQNSAPSF CPSVVLPSLT EKVSLDSWQS LALSSVVVDP
SIRHFDVAHV STAATSNFSA VRDLCLSECS QHEDCLITTL QTQPGAVRCM FYADTHSCTY
SLQGQNCRLL LREEATHIYR KPGISLLSYE ASVPSVLIVT HGRLLGRSQA IQVGTSWKQV
DQFLGVPYAA PPLAERRFRA PEPLNWTGSW DASQPRASCW QPGTRTSTSP GVSEDCLYLN
VFIPQNVAPN ASVLVFFHNT MDREGSEGWP AIDGSFLAAV GNLIVVTASY RVGVFGFLSS
GSGEVSGNWG LLDQVAALTW VQTHIRGFGG DPRRVSLAAD RAGADVASIH LLMARATNSQ
LFRRAVLMGG SALSPAAIIS HERAQQQAVA LAKEVSCPVS SSQEVVSCLR QKPANILNDA
QTKLLAVSGP FHYWGPVIDG QFLREPPARA LKRSLRAEVD LLIGSSQDDG LINRAKAVKQ
FEESQGRTSS KTAFYQALQN SLGGEDSDAR VEAAATWYYS LEHSTDDYAS FSRALENATR
DYFIICPIID MASAWAKRAR GNVFMYHAPE SYGRGSLELL ADVQFAFGLP FYPAYEGQFS
LEEKSLSLKI MQYFSHFIRS GNPNYPYEFS RKVPTFATPW PDFVPYAGGE NYKEFSALLP
NRQGLKKADC SFWSKYISSL KASADGAKGG QSAESEEEEL TAGSGLREDL LSLQEPGSKS
YSK
//
