GenomeNet

Database: UniProt
Entry: A0A1D5QH19_MACMU
LinkDB: A0A1D5QH19_MACMU
Original site: A0A1D5QH19_MACMU 
ID   A0A1D5QH19_MACMU        Unreviewed;      4930 AA.
AC   A0A1D5QH19;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   05-DEC-2018, entry version 14.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSMMUP00000047339};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSMMUP00000047339};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000047339, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000047339, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000047339,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000047339}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000047339};
RG   Ensembl;
RL   Submitted (OCT-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; JSUE03003670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000078414; ENSMMUP00000047339; ENSMMUG00000001060.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000006718; Chromosome 1.
DR   ExpressionAtlas; A0A1D5QH19; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4252   4271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4472   4492       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4546   4565       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4673   4694       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4731   4752       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4807   4830       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       84    139       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      146    191       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      199    254       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      260    317       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      325    382       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      573    783       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      999   1196       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1311   1536       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3995   4030       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      446    466       {ECO:0000256|SAM:Coils}.
FT   COILED     3032   3052       {ECO:0000256|SAM:Coils}.
FT   COILED     3299   3319       {ECO:0000256|SAM:Coils}.
FT   COILED     4384   4417       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4930 AA;  560088 MW;  E342E5EC1422401C CRC64;
     LHDDEVVLQC TATIHKEQQK LCLAAEGFGN RLCFLESTSN SKNVPPDLSI CTFVLEQSLS
     VRALQEMLAN TVEKSEGTAQ GGGHRTLLYG HAILLRHSYS GMYLCCLSTS RSSTDKLAFD
     VGLQEDTTGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV SSERYLHLSY GNGSLHVDAA
     FQQTLWSVAP ISSGSEAAQG YLIGGDVLRL LHGHMDECLT VPSGEHGEEQ RRTVHYEGGA
     VSVHARSLWR LETLRVAWSG SHIRWGQPFR LRHVTTGKYL SLMEDKNLLL MDKEKADVKS
     TAFTFRSSKE KLDVGVRKEV DGMGTSEIKY GDSVCYIQHV DTGLWLTYQS VDVKSVRMGS
     IQRKAIMHHE GHMDDGISLS RSQHEESRTA RVIRSTVFLF NRFIRGLDAL SKKAKATTVD
     LPIESVSLSL QDLIGYFHPP DEHLEHEDKQ NRLRALKNRQ NLFQEEGMIN LVLECIDRLH
     VYSSAAHFAD VAGREAGESW KSILNSLYEL LAALIRGNRK NCAQFSGSLD WLISRLERLE
     ASSGILEVLH CVLVESPEAL NIIKEGHIKS IISLLDKHGR NHKVLDVLCS LCVCHGVAVR
     SNQHLICDNL LPGRDLLLQT RLVNHVSSMR PNIFLGVSEG SAQYKKWYYE LMVDHTEPFV
     TAEATHLRVG WASTEGYSPY PGGGEEWGGN GVGDDLFSYG FDGLHLWSGC IARTVSSPNQ
     HLLRTDDVIS CCLDLSAPSI SFRINGQPVQ GMFENFNIDG LFFPVVSFSA GIKVRFLLGG
     RHGEFKFLPP PGYAPCYEAV LPKEKLKVEH SREYKQERTY TRDLLGPTVS LTQAAFTPIP
     VDTSQIVLPP HLERIREKLA ENIHELWVMN KIELGWQYGP VRDDNKRQHP CLVEFSKLPE
     QERNYNLQMS LETLKTLLAL GCHVGISDEH AEDKVKKMKL PKNYQLTSGY KPAPMDLSFI
     KLTPSQEAMV DKLAENAHNV WARDRIRQGW TYGIQQDVKN RRNPRLVPYT LLDDRTKKSN
     KDSLREAVRT LLGYGYNLEA PDQDHAARAE VCSGTGERFR IFRAEKTYAV KAGRWYFEFE
     TVTAGDMRVG WSRPGCQPDQ ELGSDERAFA FDGFKAQRWH QGNEHYGRSW QAGDVVGCMV
     DMNEHTMMFT LNGEILLDDS GSELAFKDFD VGDGFIPVCS LGVAQVGRMN FGKDVSTLKY
     FTICGLQEGY EPFAVNTNRD ITMWLSKRLP QFLQVPSNHE HIEVTRIDGT IDSSPCLKVT
     QKSFGSQNSH TDIMFYRLSM PIECAEVFSK TVAGGLPGAG LFGPKNDLED YDADSDFEVL
     MKTAHGHLVP DRVDKDKEAT KPEFNNHKDY AQEKPSRLKQ RFLLRRTKPD YSTSHSARLT
     EDVLADDRDD YDFLMQTSTY YYSVRIFPGQ EPANVWVGWI TSDFHQYDTG FDLDRVRTVT
     VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE IGCVVDAASG LLTFIANGKE
     LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL SAGLFKSEHK NPVPQCPPRL
     HVQFLSHVLW SRMPNQFLKV DVSRISERQG WLVQCLDPLQ FMSLHIPEEN RSVDILELTE
     QEELLKFHYH TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL YAIENKYMPG LLRAGYYDLL
     IDIHLSSYAT ARLMMNNEYI VPMTEETKSI TLFPDENKKH GLPGIGLSTS LRPRMQFSSP
     SFVSVSNECY QYSPEFPLDI LKAKTIQMLT EAVKEGSLHA RDPVGGTTEF LFVPLIKLFY
     TLLIMGIFHN EDLKHILQLI EPSVFKEAAT PEEESDTLEK ELSVDDAKLQ GAGEEEAKGG
     KRPKEGLLQM KLPEPVKLQM CLLLQYLCDC QVRHRIEAIV AFSDDFVAKL QDNQRFRYNE
     VMQALNMSAA LTARKTKEFR SPPQEQINML LNFKDDKSEC PCPEEIRDQL LDFHEDLMTH
     CGIELDEDGS LDGNSDLTIR GRLLSLVEKV TYLKKKQAEK PVESDSKKSS TLQQLISETM
     VRWAQESVIE DPELVRAMFV LLHRQYDGIG GLVRALPKTY TINGVSVEDT INLLASLGQI
     RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG MHETVMEVMV NVLGGGESKE
     ITFPKMVANC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS VGLASPAMRG STPLDVAAAS
     VMDNNELALA LREPDLEKVV RYLAGCGLQS CQLLVSKGYP DIGWNPVEGE RYLDFLRFAV
     FCNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAA MEEAIKIAED PSRDGPSPNS
     GSSKTLDTEE EEDDTIHMGN AIMTFYAALI DLLGRCAPEM HLIHAGKGEA IRIRSILRSL
     IPLGDLVGVI SIAFQMPTIA KDGNVVEPDM SAGFCPDHKA AMVLFLDRVY GIEVQDFLLH
     LLEVGFLPDL RAAASLDTAA LSATDMALAL NRYLCTAVLP LLTRCAPLFA GTEHHASLID
     SLLHTVYRLS KGCSLTKAQR DSIEVCLLSI CGQLRPSMMQ HLLRRLVFDV PLLNEHAKMP
     LKLLTNHYER CWKYYCLPGG WGNFGAASEE ELHLSRKLFW GIFDALSQKK YEQELFKLAL
     PCLSAVAGAL PPDYMESNYV SMMEKQSSMD SEGNFNPQPV DTSNITIPEK LEYFINKYAE
     HSHDKWSMDK LANGWIYGEI YSDSSKVQPL MKPYKLLSEK EKEIYRWPIK ESLKTMLAWG
     WRIERTREGD SMALYNRTRR ISQTSQVSVD AAHGYSPRAI DMSNVTLSRD LHAMAEMMAE
     NYHNIWAKKK KMELESKGGG NHPLLVPYDT LTAKEKAKDR EKAQDILKFL QINGYAVSRG
     FKDLELDTPS IEKRFAYSFL QQLIRYVDEA HQYILEFDGG SRGKGEHFPY EQEIKFFAKV
     VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA SNKEKEMVTS LFCKLGVLVR HRISLFGNDA
     TSIVNCLHIL GQTLDARTVM KTGLESVKSA LRAFLDNAAE DLEKTMENLK QGQFTHTRNQ
     PKGVTQIINY TTVALLPMLS SLFEHIGQHQ FGEDLILEDV QVSCYRILTS LYALGTSKSI
     YVERRRSQLK ACQILLSFEV QNAIVACGNL PYHLSTFFEY NPFFMCTSPA LSLPTNVEDV
     CPNIPSLEKL MEEIVELAES GIRYTQMPHV MEVILPMLCS YMSRWWEHGP ENNPERAEMC
     CTALNSEHMN TLLGNILKII YNNLGIDEGA WMKRLAVFSQ PIINKVKPQL LKTHFLPLME
     KLKKKAAMVV SEEDHLKAEA RGDMSEAELL ILDEFTTLAR DLYAFYPLLI RFVDYNRAKW
     LKEPNPEAEE LFRMVAEVFI YWSKSHNFKR EEQNFVVQNE INNMSFLITD TKSKMSKAAV
     SDQERKKMKR KGDRYSMQTS LIVAALKRLL PIGLNICAPG DQELIALAKN RFSLKDTEDE
     VRDIIRSNIH LQGKLEDPAI RWQMALYKDL PNRTDDTSDP EKTVERVLDI ANVLFHLEQV
     EHPQRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRA VNLFLQGYEK SWIETEEHYF
     EDKLIEDLAK PGADPPEEDE GTKRVDPLHQ LILLFSRTAL TEKCKLEEDF LYMAYADIMA
     KSCHDEEDDD GEEEVKSFEV TGSQRSKEKE MEKQKLLYQQ ARLHDRGAAE MVLQTISASK
     GETGPMVAAT LKLGIAILNG GNSTVQQKML DYLKEKKDVG FFQSLAGLMQ SCSVLDLNAF
     ERQNKAEGLG MVTEEGSGEK VLQDDEFTCD LFRFLQLLCE GHNSDFQNYL RTQTGNNTTV
     NIIISTVDYL LRVQESISDF YWYYSGKDVI DEQGQRNFSK AIQVAKQVFN TLTEYIQGPC
     TGNQQSLAHS RLWDAVVGFL HVFAHMQMKL SQDSSQIELL KELMDLQKDM VVMLLSMLEG
     NVVNGTIGKQ MVDMLVESSN NVEMILKFFD MFLKLKDLTS SDTFKEYDPD GKGVISKRDF
     HKAMESHKHY TQSETEFLLS CAETDENETL DYEEFVKRFH EPAKDIGFNV AVLLTNLSEH
     MPNDTRLQTF LELAESVLNY FQPFLGRIEI MGSAKRIERV YFEISESSRT QWEKPQVKES
     KRQFIFDVVN EGGEKEKMEL FVNFCEDTIF EMQLAAQISE SDLNERSANK EESEKERPEE
     QGPRMAFFSI LTVKSALFAL RYNILTLMRM LSLKSLKKQM KKVKKMTVKD MVTAFFSSYW
     SIFMTLLHFV ASVFRGFFRI ICSLLLGGSL VEGAKKIKVA ELLANMPDPT QDEVRGDGEE
     GERKTLEAAL PSEDLTDLKE LTEESDLLSD IFGLDLKREG GQYKLIPHNP NAGLSDLMSN
     PVPMPEVQEK FQEQKAKEEE KEEKEETKSE PEKAEGEDGE KEEKAKEDKG KQKLRQLHTH
     RYGEPEVPES AFWKKIIAYQ QKLLNYFARN FYNMRMLALF VAFAINFILL FYKVSTSSVV
     EGKELPTRSS SENAKVTSLD SSSHRIIAVH YVLEESSGYM EPTLRILAIL HTVISFFCII
     GYYCLKVPLV IFKREKEVAR KLEFDGLYIT EQPSEDDIKG QWDRLPIKCF FSYPKVMDKY
     GEFYGRDRIS ELLGMDKAAL DFSDAREKKK PKKDSSLSAV LNSIDVKYQM WKLGVVFTDN
     SFLYLAWYMT MSVLGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV
     VYLYTVVAFN FFRKFYNKSE DGDTPDMKCD DMLTCYMFHM YVGVRAGGGI GDEIEDPAGD
     EYEIYRIIFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVKEDMETK CFICGIGNDY
     FDTVPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWEFFPAGDC
     FRKQYEDQLN
//
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