ID A0A1D5QJ19_MACMU Unreviewed; 1574 AA.
AC A0A1D5QJ19;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSMMUP00000048041.2};
GN Name=ADGRB2 {ECO:0000313|Ensembl:ENSMMUP00000048041.2,
GN ECO:0000313|VGNC:VGNC:69598};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000048041.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000048041.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000048041.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR SMR; A0A1D5QJ19; -.
DR Ensembl; ENSMMUT00000067384.2; ENSMMUP00000048041.2; ENSMMUG00000023401.4.
DR VEuPathDB; HostDB:ENSMMUG00000023401; -.
DR VGNC; VGNC:69598; ADGRB2.
DR GeneTree; ENSGT00940000160103; -.
DR Proteomes; UP000006718; Chromosome 1.
DR Bgee; ENSMMUG00000023401; Expressed in superior frontal gyrus and 16 other cell types or tissues.
DR ExpressionAtlas; A0A1D5QJ19; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR CDD; cd15988; 7tmB2_BAI2; 1.
DR Gene3D; 1.25.40.610; -; 2.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR10239; ISTHMIN-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 3.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1574
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023878071"
FT TRANSMEM 925..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 958..979
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 991..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1027..1045
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1065..1092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1113..1131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1143..1163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1170..1190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 454..524
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 921..1195
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 217..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1348..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1487..1574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1574 AA; 171280 MW; 316222430C929C6C CRC64;
MTPACPLLLS VILSLRLAAA FDPAPSACSA LASGVLYGAF SLQDLFPTIA SGCSWTLENP
DPTKYSLYLR FNRQEQVCAH FAPRLLPLDH YLVNFTCLRP SSEEAVAQAE SEVGRPEEEE
AEAAAGLELC SGSGPFTFLH FDKNFVQLCL SAEPSEAPRL LAPAALAFRF VEVLLINNNN
SSQFTCGVLC RWSEECGRAA GRACGFAQPG CSCPGEAGAG SATTTSPGPP AAHTLSNALV
PGGPAPPAEA DLHSGSSNDL FTTEMRYGEE PEEEPKVKTQ WPRSADEPGL YMAQTGDPAA
EEWSPWSVCS LTCGQGLQVR TRSCVSSPYG TLCSGPLRET RPCNNSATCP VEGQWLEWGP
WGPCSTSCAN GTQQRSRKCS VAGPAWATCT GALTDTRECS NLECPATDSK WGPWNAWSLC
SKTCDTGWQR RFRMCQATGT QGYPCEGTGE EVKPCSEKRC PAFHEMCRDE YVMLMTWKKA
AAGEIIYNKC PPNASGSASR RCLLSAQGVA YWGLPSFARC ISHEYRYLYL SLREHLAKGQ
RMLAGEGMSQ VVRSLQELLA RRTYYSGDLL FSVDILRNVT DTFKRATYVP SADDVQVPPR
RKEGGGWRRP RLKGEARPLG RVCCRGSKFG CSGGNPLFPG ARTPCHSLLS PQRFFQVVSF
MVDAENKEKW DDAQQVSPGS VHLLRVVEDF IHLVGDALKA FQSSLIVTDN LVISIQREPV
SAVSSDITFP MRGRRGMKDW VRHSEDRLFL PKEVLSLSSP GKPATSGAAG SPGRGRGPGT
VPPGPGHSHQ RLLPADPDES SYFVIGAVLY RTLGLILPPP RPPLAVTSRV MTVTVRPPTQ
PPAEPLITVE LSYIINGTTD PHCASWDYSR ADASSGDWDT ENCQTLETQA AHTRCQCQHL
STFAVLAQPP KDLTLELAGS PSVPLVIGCA VSCMALLTLL AIYAAFWRFI KSERSIILLN
FCLSILASNI LILVGQSRVL SKGVCTMTAA FLHFFFLSSF CWVLTEAWQS YLAVIGRMRT
RLVRKRFLCL GWGLPALVVA VSVGFTRTKG YGTSSYCWLS LEGGLLYAFV GPAAVIVLVN
MLIGIIVFNK LMARDGISDK SKKQRAGSER CPWASLLLPC SACGAVPSPL LSSASARNAM
ASLWSSCVVL PLLALTWMSA VLAMTDRRSV LFQALFAVFN SAQGFVITAV HCFLRREVQD
VVKCQMGVCR ADESEDSPDS CKNGQLQILS DFEKDVDLAC QTVLFKEVNT CNPSTITGTL
SRLSLDEDEE PKSCLVGPEG SLSFSPLPGN ILVPMAASPG LGEPPPPQEA NPVYMCGEGG
LRQLDLTWLR PTEPGSEGDY MVLPRRTLSL QPGGGGGGGE DAPRARPEGT PRRAAKTVAH
TEGYPSFLSV DHSGLGLGPA YGSLQNPYGM TFQPPPPTPS ARQVPEPGER SRTMPRTVPG
STMKMGSLER KKLRYSDLDF EKVMHTRKRH SELYHELNQK FHTFDRYRSQ STAKREKRWS
VSSGGAAERS VCTDKPSPGE RPSLSQHRRH QSWSTFKSMT LGSLPPKPRE RLTLHRTAAW
EPTEPPDGDF QTEV
//
