ID A0A1D5QJN1_MACMU Unreviewed; 2830 AA.
AC A0A1D5QJN1;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=WNK1 {ECO:0000313|Ensembl:ENSMMUP00000048254.2,
GN ECO:0000313|VGNC:VGNC:78960};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000048254.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000048254.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000048254.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR SMR; A0A1D5QJN1; -.
DR Ensembl; ENSMMUT00000064161.2; ENSMMUP00000048254.2; ENSMMUG00000018650.4.
DR VEuPathDB; HostDB:ENSMMUG00000018650; -.
DR VGNC; VGNC:78960; WNK1.
DR GeneTree; ENSGT00940000155474; -.
DR Proteomes; UP000006718; Chromosome 11.
DR Bgee; ENSMMUG00000018650; Expressed in Ammon's horn and 22 other cell types or tissues.
DR ExpressionAtlas; A0A1D5QJN1; baseline.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0042592; P:homeostatic process; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14030; STKc_WNK1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024678; Kinase_OSR1/WNK_CCT.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR13902; SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED; 1.
DR PANTHER; PTHR13902:SF46; SERINE_THREONINE-PROTEIN KINASE WNK1; 1.
DR Pfam; PF12202; OSR1_C; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 221..479
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1043..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1438..1533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1870..1890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2147..2202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2281..2361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2436..2457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2527..2611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2780..2801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1438..1458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1509..1529
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2284..2300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2301..2321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2337..2361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2548..2611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2830 AA; 298750 MW; 111003A2FAC353C6 CRC64;
MSGGAAEKQS STPGSLFLSP PAPAPKNGSS SDSSVGEKLG AAAADAGTGR TEEYRRRRHT
MDKDSRGAAA TTTTTEHRFF RRSVICDSNA TALELPGLPL ALPQPGIPAV VPQSAPPEPH
REETVAATAA SQVAQQPPAA AAPGEQAVAG PAPSTVPSST SKDRPVSQPS LVGSKEEPPP
ARSGSGGGSA KEPQEERSQQ QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD
TETTVEVAWC ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL KCDNIFITGP
TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD ESVDVYAFGM CMLEMATSEY
PYSECQNAAQ IYRRVTSGVK PASFDKVAIP EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ
EETGVRVELA EEDDGEKIAI KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM
VESGYVCEGD HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KKKQEESSVK QQVEQSNASQ
TGIKQLPSAS TGVPTASTTS ASVSTQVEPE EPEADQHQQL QYQQPSISVL SDGTVDSGQG
SSVFTESRVS SQQTVSYGSQ HEQAHSAGTV PGHVPSAVQA QSQPHGVYPP SSVPQSMAHP
CGGTPTYPES QIFFPTIHER PVSFSPPPTC PPKVAISQRR KSTSFLEAQT HHLPPLLRTV
GQSLLPPGGS PTHWTPEAVV MLGTTASRVT GESCEIQVHP MCEPSQVYSD YRPGLVLPEE
AHYFIPQEAV YLAGVQYQAQ VAEQYEGIPY NSSVLSSPMK QIPEQKPVQG GPTSSSVFEF
PSGQAFLVGH LQNLRLDSGL SPGSPLSSIS APISTDATRL KFHPVFVPHS APAVLTHNNE
SRSNCVFEFH VHTPSSSSGE GGGILPQRVY RNRQVAVDLN QEELPPQSVG LHGYLQPVTE
EKHNYHAPEL TVSVVEPIGQ NWPIGSPEYS SDSSQITSSD PSDFQSPPPT GGAAASFGSD
VSLPFIHLPQ TVLQESPLFF CFPQGTTSQQ VLTASFSSGG SALHPQAQGQ SQGQPSSSSL
TGVSSSQPIQ HPQQQQGIQQ TAPPQQTVQY SLSQTSTSSE ATTAQPASQP QAPQVLPQVS
AGKQLPVSQP VPTIQGEPQI PVATQPSAVP VHSGAHFLPV GQPLPTSLLP QYPVSQIPIS
APHVSTAQTG FSSLPITMAA GITQPLLTLA SSATTAAIPG VSTVVPSQLP TLLQPVTQLP
SQVHPQLLQP AVQSMGVPAN LGQAAEVPLS SGDVLYQGFP PRLPPQYPGD SNIAPSSNVA
SVCIHSTVLS PPMPTEVLAT PGYFPTVVQP YVESNLLVPM GGVGGQVQVS QPGVSLAQAP
TTSSQQAVLE STQGVSQVAP PEPVPVAQPQ PTQPATLASS IDSAHSDVAS GMSDGNENVP
SSSGRHEGRT TKRHYRKSVR SRSRHEKTSR PKLRILNVSN KGDRVVECQL ETHNRKMVTF
KFDLDGDNPE EIATIMVNND FILAIERESF VDQVREIIEK ADEMLSEDVS VEPEGDQGLE
SLQGKDDYGF SGSQKLEGEF KQPIPVSSMP QQIGIPTSSL TQVVHSAGRR FIVSPVPESR
LRESKLFTSE ITDTVAASTS QSPGMNLSHS ASSLSLQQAF SELRHAQMTE GPNTAPPNFS
HIAPTFPVVP PFLSSIAGVP TTAAATVPVP ATSSPPNDMS TSVIQSEVTV PTEEGIAGVA
TSTGVATAGG LHIPPVSESP VLSSVVSSTT IPAVVSISTT SPSLQVPTST SENIVSSTAL
YPSVTVSATS ASAGGSTVTP GPKPPAVVSP QAAGSTTVGV ALTSVSATTS LPSTASQLSI
QLSSSTSAPT LAETVVVSAH SLDKTSHSIT TGLALSLSAP SSSSSPGAGV SSSISQPGGL
HPLVIPSVIA STPILPQAAG PTSTPLLPQV PSIPPLVQPV ANVPAVQQTL IHSQPQPALL
PNQPHTHCPE IDSDTQPKAP GIDDIKTLEE KLRSLFSEHS SSGAQHAPVS LETSLVVEST
VTPGIPTTAV APSKLLTSTT STCLPPTNLP LGTVALPVTP VVTPGQVSTP VSTAASGVKP
GTAPSKPPLT KPPVLPVGTE LPAGALPSEQ LPPFPGPSLT QSQQPLEDLD AQLRRTLSPE
IITTVTSAVG PVSVVAPAAV TEAGAQPQKD VSQVTEKGPV LATSSGAGVF KMGRFQVSVA
ADDTQKEGKS KSEDAKSVHF ESSTSESSVL SSSSPESTLV KPEPNGITIP GISSDVPESA
HKTTASEAKS DTGQPTKVGR FQVTTTANKV GRFSVSKTED KITDTKKEGP VASPPFMDLE
QAVLPAVIPK KEKPELSEPS HLNGPSSDLE AAFLSRDVDD GSGSPHSPHQ LSSKSLPIQN
LSQSLSNSFN SSYMSSDNES DIEDEDLKLE LRRLRDKHLK EIQDLQSRQK HEIESLYTKL
GKVPPAVIIP PAAPLSGRRR RPTKSKGSKS SRSSSLGNKS PQLSGNLSGQ SAASVLHPQQ
TLHPPGNIPE SGQNQLLQPL KPSPSSDNLY SAFTSDGAIS VPSLSAPGQG CAKFNCASEQ
VTFKPGGRRT RFLMCPPAEP KSGTSSTNTV GATVNSQAAQ AQPPAMTSSR KGTFTDDLHK
LVDNWARDAM ILSGRRGSKG HMNYEGPGMA RKFSAPGQLC ISMTSNLGGS APISAASATS
LGHFTKSMCP PQQYGFPATP FGAQWSGTGG PAPQPIGQFQ PVGTASLQNF NISNLQKSIS
NPPGSNLRTT
//
