GenomeNet

Database: UniProt
Entry: A0A1D5QMP3_MACMU
LinkDB: A0A1D5QMP3_MACMU
Original site: A0A1D5QMP3_MACMU 
ID   A0A1D5QMP3_MACMU        Unreviewed;      4760 AA.
AC   A0A1D5QMP3;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   05-DEC-2018, entry version 15.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSMMUP00000049318};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSMMUP00000049318};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000049318, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000049318, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000049318,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000049318}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000049318};
RG   Ensembl;
RL   Submitted (OCT-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; JSUE03037911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000057991; ENSMMUP00000049318; ENSMMUG00000005270.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000006718; Chromosome 7.
DR   ExpressionAtlas; A0A1D5QMP3; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4103   4120       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4308   4328       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4376   4395       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4507   4525       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4568   4589       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4648   4671       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       88    143       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      150    195       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      203    257       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      263    321       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      331    388       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      515    726       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1151   1371       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3816   3851       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      447    467       {ECO:0000256|SAM:Coils}.
FT   COILED     3123   3143       {ECO:0000256|SAM:Coils}.
FT   COILED     4230   4257       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4760 AA;  539542 MW;  F80364C043EA13E5 CRC64;
     GMEELEDEVV LQCIATIHKE QRKFCLAAEG LGNRLCFLEP TSEAKYIPPD LCVCNFVLEQ
     SLSVRALQEM LANTGENGGE GAAQGGGHRT LLYGHAILLR HSFSGMYLTC LTTSRSQTDK
     LAFDVGLREH ATGEACWWTI HPASKQRSEG EKVRIGDDLI LVSVSSERYL HLSVSNGNIQ
     VDASFMQTLW NVHPTCSGSS IEEGYLLGGH VVRLFHGHDE CLTIPSTDQN DSQHRRIFYE
     AGGAGTRARS LWRVEPLRIS WSGSNIRWGQ AFRLRHLTTG HYLALTEDQG LILQDRAKAD
     TKSTAFSFRA SKELKEKLDS SHKRDIEGMG VPEIKYGDSV CFVQHIASGL WVTYKAQDAK
     TSRLGPLKRK VILHQEGHMD DGLTLQRCQR EESQAARIIR NTTALFSQFV SGNNRTAAPI
     TLPIGEVLQT LQDLIAYFQP PEEEMRHEDK QNKLRSLKNR QNLFKEEVIR LAFSSFYKLD
     RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI LCSLCLCNGV
     AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW YFELIIDQVD
     PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW SGRIPRAVAS
     INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS FSAGVKVRFL
     MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT TQFLSQASFI
     PCPIDTSQVV LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR QHPCLVEFSK
     LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS NGYKPAPLDL
     SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV PYALLDERTK
     KSNRDSLREA VRTFVGYGYN IEPSDQELAD SAVEKVSIDK IRFFRVERSY AVRSGKWYFE
     FEVVTGGDMR VGWARPGCRP DPLCLKAAGG YFGRTWQPGD VVGCMINLDD ASMIFTLNGE
     LLITNKGSEL AFADYEIENG FVPICCLGLS QIGRMNLGTD ASTFKFYTMC GLQEGFEPFA
     VNMNRDVAMW FSKRLPTFVN VPKDHPHIEV MRIDGTMDSP PCLKVTHKTF GTQHSNADMI
     YCRLSMPVEC HSSFSHSPCL DSEFSEALVS AQCYYAIRIF AGQDPSCVWV GWVTPDYHLY
     SEKFDLNKNC TVTVTLGDER GRVHESVKRS NCYMVWGGDI VASSQKSNRS NVDLEIGCLV
     DLAMGMLSFS ANGKELGTCY QVEPNTKVFP AVFLQPTSTS LFQFELGKLK NAMPLSAAIF
     KSEEKNPVPQ CPPRLDVQTI QPVLWSRMPN SFLKVESERV SERHGWVVQC LEPLQMMALH
     IPEENRCVDI LELCEQEDLM RFHYHTLRLY SAVCALGNSR VAYALCSHVD LSQLFYAIDN
     KYLPGLLRAG FYDLLISIHL ANAKERKLMM KNEYIIPITS TTRNIRLFPD ESKRHGLPGV
     GLRTCLKPGF RFSTPCFVAT GEEHQKQSPE IPLESLRTKA LSMLTEAVQC SGAHIRDPVG
     GSVEFQFVPV LKLIGTLLVM GVFDDDDVRQ ILLLIDPSVF GEHSADTEEG TEKEEVTQVE
     EKAVEAGEKA GKEAPVKGLL QTRLPESVKL QMCELLSYLC DCELQHRVEA IVAFGDIYVS
     KLQANQKFRY NELMQALNMS AALTARKTKE FRSPPQEQIN MLLNFQLGEN CPCPEELREE
     LYDFHEDLLL HCGVPLEEEE EEEEDTSWTG KLRALVYKIK GPPKPEKEQP TEEEERCPTT
     LKELISQTMI CWAQEDQIQD AELVRMMFNL LRRQYDSIGE LLQALRKTYT ISHASVSDTI
     NLLAALGQIR SLLSVRMGKE EELLMINGLG DIMNNKVFYQ HPNLMRVLGM HETVMEVMVN
     VLSTEKSQIA FPKMVASCCR FLCYFCRISR QNQKAMFEHL SYLLENSSVG LASPSMRGST
     PLDVAASSVM DNNELALGLE EPDLEKVVTY LAGCGLQSCP MLLAKGYPDV GWNPIEGERY
     LSFLRFAVFV NSESVEENAS VVVKLLIRRP ECFGPALRGE GGNGLLAAMQ GAIKISENPT
     LDLPSQGYKR EVTEADEEEE EIVHMGNAIM SFYSALIDLL GRCAPEMHLI QTGKGEAIRI
     RSILRSLVPT EDLVGIISIP LKLPSLNKDG SVSEPDMAAN FCPDHKAPMV LFLDRVYGIK
     DQTFLLHLLE VGFLPDLRAS ASLDTVSLST TEAALALNRY ICSAVLPLLT RCAPLFAGTE
     HCTSLIDSTL QTIYRLSKGR SLTKAQRDTI EECLLAICNH LRPSMLQQLL RRLVFDVPQL
     NEYCKMPLKL LTNHYEQCWK YYCLPSGWGS YGLAVEEELH LTEKLFWGIF DSLSHKKYDP
     DLFRMALPCL SAIAGALPPD YLDTRITATL EKQISVDADG NFDPKPINTV NFSLPEKLEY
     IVTKYAEHSH DKWACDKSQS GWKYGISLDE NVKTHPLIRP FKTLTEKEKE IYRWPARESL
     KTMLAVGWTV ERTKEGEALV QQRENEKLRS VSQANQGNSY SPAPLDLSNV VLSRELQGMV
     EVVAENYHNI WAKKKKLELE SKGGGSHPLL VPYDTLTAKE KFKDREKAQD LFKFLQVNGV
     IVSRGMKDME LDASSMEKRF AYKFLKKILK YVDSAQEFIA HLEAIVSSGK TEKSPHDQEI
     KFFAKVLLPL VDQYFTNHRL YFLSSPLKPL SSSGYASHKE KEMVASLFCK LAALVRHRIS
     LFGSDSTTMV SCLHILAQTL DTRTVMKSGS ELVKAGLRAF FENGAEDLEK TSENLKLGKF
     THSRTQIQGV SQNVNYTTVA LLPILTSIFE HVAQHQFGMD LLLGDVQISC YHILCSLYSL
     GTGKNIYVER QRPALGECLA SLAAAIPVAF LEPTLNRYNP LSVFNTKTPR ERSILGMPDT
     VEDMCPDIPQ LEGLMKEIND LAESGARYTE VPHVIEVILP MLCNYLSYWW ERGPENLPPS
     TGQCCTKVTS EHLSLILGNI LKIINNNLGI DEASWMKRIA VYAQPIISKA RPDLLRSHFI
     PTLEKLKKKA VKTVQEEEQL RADGKGDTQE AELLILDEFA VLCRDLYAFY PMLIRYVDNN
     RSNWLKSPDA DSDQLFRMVA EVFILWWLWL VFYGYLIRLC STHSFHCPLK WPQGGRLPLT
     GGQDQERKKT KRRGDLYSIQ TSLIVAALKK MLPIGLNMCT PGDQELISLA KSRYGHRDTD
     EEVREHLRNN LHLQEKSDDP AVKWQLNLYK DVLKSEEPFN PEKTVERVQR ISAAVFHLEQ
     VEQPLRSKKA VWHKLLSKQR KRAVVACFRM APLYNLPRHR SINLFLHGYQ RFWIETEEYS
     FEEKLVQDLA KSPKVEEEEE EETEKQPDPL HQIILYFSRN ALTERSKLED DPLYTSYSSM
     MAKSCQSGED EEADEDKEKT FEEKEMEKQK TLYQQARLHE RGAAEMVLQM ISASKGEMSP
     MVVETLKLGI AILNGGNAGV QQKMLDYLKE KKDAGFFQSL SGLMQSCSVL DLNAFERQNK
     AEGLGMVTEE GTLIVRERGK FQFLNDEFTR DLFRFLQLLC EGHNSDFQNF LRTQMGNTTT
     VNVIISTVDY LLRLQESISD FYWYYSGKDI IDESGQHNFS KALAVTKQIF NSLTEYIQGP
     CIGNQQSLAH SRLWDAVVGF LHVFANMQMK LSQDSSQIEL LKELLDLLQD MVVMLLSLLE
     GNVVNGTIGK QMVDTLVESS TNVEMILKFF DMFLKLKDLT SSDTFKEYDP DGKGIISKRE
     FQKAMEGQKQ YTQSEIDFLL SCAEADENDM FNYIDFVDRF HEPAKDIGFN VAVLLTNLSE
     HMPNDSRLKC LLDPAESVLN YFEPYLGRIE IMGGAKKIER VYFEISESSR TQWEKPQVKE
     SKRQFIFDVV NEGGEQEKME LFVNFCEDTI FEMQLASQIS ESDSADRPEE EEEGEDSSYV
     LEIAGEEEED GSFEPASAFA MACASVKRNV ADFLKRATLK NLRKQYRNVK KMTAKELVKV
     LCSFFWMLFL GLFQMLFTIL GGIFQILWST VFGGGLVEGA KNIRVTKILG DMPDPTQFGI
     HDDTMEAERA EVMEPGITTE LVHFMKGEKG DTDIMSDLFG LHPKKEGSLK HGPEVGLGDL
     SEIIGKDEPP TLESTVQKKR KAQAAEMKAA NEAEGKVESE KADVEDGEKE DKDKEEEQAE
     YLWTEVTKKK KRRCGQKAEK PEAFTANFFK GLDIYQTKLL HYLARNFYNL RFLALFVAFA
     INFILLFYKV TEEPLEEETE DVANLWNSFN DEEEEEAMVF FVLQESTGYM APTLRALAII
     HTIISLVCVV GYYCLKVPLV VFKREKEIAR KLEFDGLYIT EQPSEDDIKG QWDRLVINTP
     SFPNNYWDKF VKRKVINKYG DLYGAERIAE LLGLDKNALD FSPVEETKAE AASLVSWLSS
     IDMKYHIWKL GVVFTDNSFL YLAWYTTMSV LGHYNNFFFA AHLLDIAMGF KTLRTILSSV
     THNGKQLVLT VGLLAVVVYL YTVVAFNFFR KFYNKSEDDD EPDMKCDDMM TCYLFHMYVG
     VRAGGGIGDE IEDPAGDPYE MYRIVFDITF FFFVIVILLA IIQGLIIDAF GELRDQQEQV
     REDMETKCFI CGIGNDYFDT TPHGFETHTL QEHNLANYLN KHPLFPLFQE SYVWKMYQER
     CWDFFPAGDC FRKQYEDQLG
//
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