GenomeNet

Database: UniProt
Entry: A0A1D5QXA6_MACMU
LinkDB: A0A1D5QXA6_MACMU
Original site: A0A1D5QXA6_MACMU 
ID   A0A1D5QXA6_MACMU        Unreviewed;      4934 AA.
AC   A0A1D5QXA6;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   05-DEC-2018, entry version 14.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSMMUP00000052686};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSMMUP00000052686};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000052686, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000052686, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000052686,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000052686}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000052686};
RG   Ensembl;
RL   Submitted (OCT-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; JSUE03003670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000060395; ENSMMUP00000052686; ENSMMUG00000001060.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000006718; Chromosome 1.
DR   ExpressionAtlas; A0A1D5QXA6; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4256   4275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4476   4496       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4550   4569       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4677   4698       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4735   4756       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4811   4834       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       84    139       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      146    191       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      199    254       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      260    317       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      325    382       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      573    783       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      999   1196       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1311   1536       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3999   4034       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      446    466       {ECO:0000256|SAM:Coils}.
FT   COILED     3032   3052       {ECO:0000256|SAM:Coils}.
FT   COILED     3299   3319       {ECO:0000256|SAM:Coils}.
FT   COILED     4388   4421       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4934 AA;  560559 MW;  02687B3061C1812D CRC64;
     LHDDEVVLQC TATIHKEQQK LCLAAEGFGN RLCFLESTSN SKNVPPDLSI CTFVLEQSLS
     VRALQEMLAN TVEKSEGTAQ GGGHRTLLYG HAILLRHSYS GMYLCCLSTS RSSTDKLAFD
     VGLQEDTTGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV SSERYLHLSY GNGSLHVDAA
     FQQTLWSVAP ISSGSEAAQG YLIGGDVLRL LHGHMDECLT VPSGEHGEEQ RRTVHYEGGA
     VSVHARSLWR LETLRVAWSG SHIRWGQPFR LRHVTTGKYL SLMEDKNLLL MDKEKADVKS
     TAFTFRSSKE KLDVGVRKEV DGMGTSEIKY GDSVCYIQHV DTGLWLTYQS VDVKSVRMGS
     IQRKAIMHHE GHMDDGISLS RSQHEESRTA RVIRSTVFLF NRFIRGLDAL SKKAKATTVD
     LPIESVSLSL QDLIGYFHPP DEHLEHEDKQ NRLRALKNRQ NLFQEEGMIN LVLECIDRLH
     VYSSAAHFAD VAGREAGESW KSILNSLYEL LAALIRGNRK NCAQFSGSLD WLISRLERLE
     ASSGILEVLH CVLVESPEAL NIIKEGHIKS IISLLDKHGR NHKVLDVLCS LCVCHGVAVR
     SNQHLICDNL LPGRDLLLQT RLVNHVSSMR PNIFLGVSEG SAQYKKWYYE LMVDHTEPFV
     TAEATHLRVG WASTEGYSPY PGGGEEWGGN GVGDDLFSYG FDGLHLWSGC IARTVSSPNQ
     HLLRTDDVIS CCLDLSAPSI SFRINGQPVQ GMFENFNIDG LFFPVVSFSA GIKVRFLLGG
     RHGEFKFLPP PGYAPCYEAV LPKEKLKVEH SREYKQERTY TRDLLGPTVS LTQAAFTPIP
     VDTSQIVLPP HLERIREKLA ENIHELWVMN KIELGWQYGP VRDDNKRQHP CLVEFSKLPE
     QERNYNLQMS LETLKTLLAL GCHVGISDEH AEDKVKKMKL PKNYQLTSGY KPAPMDLSFI
     KLTPSQEAMV DKLAENAHNV WARDRIRQGW TYGIQQDVKN RRNPRLVPYT LLDDRTKKSN
     KDSLREAVRT LLGYGYNLEA PDQDHAARAE VCSGTGERFR IFRAEKTYAV KAGRWYFEFE
     TVTAGDMRVG WSRPGCQPDQ ELGSDERAFA FDGFKAQRWH QGNEHYGRSW QAGDVVGCMV
     DMNEHTMMFT LNGEILLDDS GSELAFKDFD VGDGFIPVCS LGVAQVGRMN FGKDVSTLKY
     FTICGLQEGY EPFAVNTNRD ITMWLSKRLP QFLQVPSNHE HIEVTRIDGT IDSSPCLKVT
     QKSFGSQNSH TDIMFYRLSM PIECAEVFSK TVAGGLPGAG LFGPKNDLED YDADSDFEVL
     MKTAHGHLVP DRVDKDKEAT KPEFNNHKDY AQEKPSRLKQ RFLLRRTKPD YSTSHSARLT
     EDVLADDRDD YDFLMQTSTY YYSVRIFPGQ EPANVWVGWI TSDFHQYDTG FDLDRVRTVT
     VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE IGCVVDAASG LLTFIANGKE
     LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL SAGLFKSEHK NPVPQCPPRL
     HVQFLSHVLW SRMPNQFLKV DVSRISERQG WLVQCLDPLQ FMSLHIPEEN RSVDILELTE
     QEELLKFHYH TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL YAIENKYMPG LLRAGYYDLL
     IDIHLSSYAT ARLMMNNEYI VPMTEETKSI TLFPDENKKH GLPGIGLSTS LRPRMQFSSP
     SFVSVSNECY QYSPEFPLDI LKAKTIQMLT EAVKEGSLHA RDPVGGTTEF LFVPLIKLFY
     TLLIMGIFHN EDLKHILQLI EPSVFKEAAT PEEESDTLEK ELSVDDAKLQ GAGEEEAKGG
     KRPKEGLLQM KLPEPVKLQM CLLLQYLCDC QVRHRIEAIV AFSDDFVAKL QDNQRFRYNE
     VMQALNMSAA LTARKTKEFR SPPQEQINML LNFKDDKSEC PCPEEIRDQL LDFHEDLMTH
     CGIELDEDGS LDGNSDLTIR GRLLSLVEKV TYLKKKQAEK PVESDSKKSS TLQQLISETM
     VRWAQESVIE DPELVRAMFV LLHRQYDGIG GLVRALPKTY TINGVSVEDT INLLASLGQI
     RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG MHETVMEVMV NVLGGGESKE
     ITFPKMVANC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS VGLASPAMRG STPLDVAAAS
     VMDNNELALA LREPDLEKVV RYLAGCGLQS CQLLVSKGYP DIGWNPVEGE RYLDFLRFAV
     FCNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAA MEEAIKIAED PSRDGPSPNS
     GSSKTLDTEE EEDDTIHMGN AIMTFYAALI DLLGRCAPEM HLIHAGKGEA IRIRSILRSL
     IPLGDLVGVI SIAFQMPTIA KDGNVVEPDM SAGFCPDHKA AMVLFLDRVY GIEVQDFLLH
     LLEVGFLPDL RAAASLDTAA LSATDMALAL NRYLCTAVLP LLTRCAPLFA GTEHHASLID
     SLLHTVYRLS KGCSLTKAQR DSIEVCLLSI CGQLRPSMMQ HLLRRLVFDV PLLNEHAKMP
     LKLLTNHYER CWKYYCLPGG WGNFGAASEE ELHLSRKLFW GIFDALSQKK YEQELFKLAL
     PCLSAVAGAL PPDYMESNYV SMMEKQSSMD SEGNFNPQPV DTSNITIPEK LEYFINKYAE
     HSHDKWSMDK LANGWIYGEI YSDSSKVQPL MKPYKLLSEK EKEIYRWPIK ESLKTMLAWG
     WRIERTREGD SMALYNRTRR ISQTSQVSVD AAHGYSPRAI DMSNVTLSRD LHAMAEMMAE
     NYHNIWAKKK KMELESKGGG NHPLLVPYDT LTAKEKAKDR EKAQDILKFL QINGYAVSRG
     FKDLELDTPS IEKRFAYSFL QQLIRYVDEA HQYILEFDGG SRGKGEHFPY EQEIKFFAKV
     VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA SNKEKEMVTS LFCKLGVLVR HRISLFGNDA
     TSIVNCLHIL GQTLDARTVM KTGLESVKSA LRAFLDNAAE DLEKTMENLK QGQFTHTRNQ
     PKGVTQIINY TTVALLPMLS SLFEHIGQHQ FGEDLILEDV QVSCYRILTS LYALGTSKSI
     YVERRRSQLK ACQILLSFEV QNAIVACGNL PYHLSTFFEY NPFFMCTSPA LSLPTNVEDV
     CPNIPSLEKL MEEIVELAES GIRYTQMPHV MEVILPMLCS YMSRWWEHGP ENNPERAEMC
     CTALNSEHMN TLLGNILKII YNNLGIDEGA WMKRLAVFSQ PIINKVKPQL LKTHFLPLME
     KLKKKAAMVV SEEDHLKAEA RGDMSEAELL ILDEFTTLAR DLYAFYPLLI RFVDYNRAKW
     LKEPNPEAEE LFRMVAEVFI YWSKSHNFKR EEQNFVVQNE INNMSFLITD TKSKMSKAAV
     SDQERKKMKR KGDRYSMQTS LIVAALKRLL PIGLNICAPG DQELIALAKN RFSLKDTEDE
     VRDIIRSNIH LQGKLEDPAI RWQMALYKDL PNRTDDTSDP EKTVERVLDI ANVLFHLEQV
     RLCVNSVIFA LVEHPQRSKK AVWHKLLSKQ RKRAVVACFR MAPLYNLPRH RAVNLFLQGY
     EKSWIETEEH YFEDKLIEDL AKPGADPPEE DEGTKRVDPL HQLILLFSRT ALTEKCKLEE
     DFLYMAYADI MAKSCHDEED DDGEEEVKSF EEKEMEKQKL LYQQARLHDR GAAEMVLQTI
     SASKGETGPM VAATLKLGIA ILNGGNSTVQ QKMLDYLKEK KDVGFFQSLA GLMQSCSVLD
     LNAFERQNKA EGLGMVTEEG SGEKVLQDDE FTCDLFRFLQ LLCEGHNSDF QNYLRTQTGN
     NTTVNIIIST VDYLLRVQES ISDFYWYYSG KDVIDEQGQR NFSKAIQVAK QVFNTLTEYI
     QGPCTGNQQS LAHSRLWDAV VGFLHVFAHM QMKLSQDSSQ IELLKELMDL QKDMVVMLLS
     MLEGNVVNGT IGKQMVDMLV ESSNNVEMIL KFFDMFLKLK DLTSSDTFKE YDPDGKGVIS
     KRDFHKAMES HKHYTQSETE FLLSCAETDE NETLDYEEFV KRFHEPAKDI GFNVAVLLTN
     LSEHMPNDTR LQTFLELAES VLNYFQPFLG RIEIMGSAKR IERVYFEISE SSRTQWEKPQ
     VKESKRQFIF DVVNEGGEKE KMELFVNFCE DTIFEMQLAA QISESDLNER SANKEESEKE
     RPEEQGPRMA FFSILTVKSA LFALRYNILT LMRMLSLKSL KKQMKKVKKM TVKDMVTAFF
     SSYWSIFMTL LHFVASVFRG FFRIICSLLL GGSLVEGAKK IKVAELLANM PDPTQDEVRG
     DGEEGERKTL EAALPSEDLT DLKELTEESD LLSDIFGLDL KREGGQYKLI PHNPNAGLSD
     LMSNPVPMPE VQEKFQEQKA KEEEKEEKEE TKSEPEKAEG EDGEKEEKAK EDKGKQKLRQ
     LHTHRYGEPE VPESAFWKKI IAYQQKLLNY FARNFYNMRM LALFVAFAIN FILLFYKVST
     SSVVEGKELP TRSSSENAKV TSLDSSSHRI IAVHYVLEES SGYMEPTLRI LAILHTVISF
     FCIIGYYCLK VPLVIFKREK EVARKLEFDG LYITEQPSED DIKGQWDRLP IKCFFSYPKV
     MDKYGEFYGR DRISELLGMD KAALDFSDAR EKKKPKKDSS LSAVLNSIDV KYQMWKLGVV
     FTDNSFLYLA WYMTMSVLGH YNNFFFAAHL LDIAMGFKTL RTILSSVTHN GKQLVLTVGL
     LAVVVYLYTV VAFNFFRKFY NKSEDGDTPD MKCDDMLTCY MFHMYVGVRA GGGIGDEIED
     PAGDEYEIYR IIFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQQEQVKED METKCFICGI
     GNDYFDTVPH GFETHTLQEH NLANYLFFLM YLINKDETEH TGQESYVWKM YQERCWEFFP
     AGDCFRKQYE DQLN
//
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