GenomeNet

Database: UniProt
Entry: A0A1D5QY89_MACMU
LinkDB: A0A1D5QY89_MACMU
Original site: A0A1D5QY89_MACMU 
ID   A0A1D5QY89_MACMU        Unreviewed;      4811 AA.
AC   A0A1D5QY89;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   05-DEC-2018, entry version 16.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSMMUP00000053020};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSMMUP00000053020};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000053020, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000053020, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000053020,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000053020}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000053020};
RG   Ensembl;
RL   Submitted (OCT-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; JSUE03037911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000075263; ENSMMUP00000053020; ENSMMUG00000005270.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000006718; Chromosome 7.
DR   ExpressionAtlas; A0A1D5QY89; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4135   4159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4359   4379       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4427   4446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4558   4576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4619   4640       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4699   4722       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       88    143       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      150    195       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      203    257       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      263    321       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      331    388       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      538    749       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      965   1161       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1207   1419       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3867   3902       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      447    467       {ECO:0000256|SAM:Coils}.
FT   COILED     3172   3192       {ECO:0000256|SAM:Coils}.
FT   COILED     4281   4308       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4811 AA;  545395 MW;  179C42A4E4AD155C CRC64;
     GMEELEDEVV LQCIATIHKE QRKFCLAAEG LGNRLCFLEP TSEAKYIPPD LCVCNFVLEQ
     SLSVRALQEM LANTGENGGE GAAQGGGHRT LLYGHAILLR HSFSGMYLTC LTTSRSQTDK
     LAFDVGLREH ATGEACWWTI HPASKQRSEG EKVRIGDDLI LVSVSSERYL HLSVSNGNIQ
     VDASFMQTLW NVHPTCSGSS IEEGYLLGGH VVRLFHGHDE CLTIPSTDQN DSQHRRIFYE
     AGGAGTRARS LWRVEPLRIS WSGSNIRWGQ AFRLRHLTTG HYLALTEDQG LILQDRAKAD
     TKSTAFSFRA SKELKEKLDS SHKRDIEGMG VPEIKYGDSV CFVQHIASGL WVTYKAQDAK
     TSRLGPLKRK VILHQEGHMD DGLTLQRCQR EESQAARIIR NTTALFSQFV SGNNRTAAPI
     TLPIGEVLQT LQDLIAYFQP PEEEMRHEDK QNKLRSLKNR QNLFKEELLS EVFNSFPTAL
     IRGNRNNCAQ FSNNLDWLIS KLDRLESSSG ILEVLHCILT ESPEALNLIA EGHIKSIISL
     LDKHGRNHKV LDILCSLCLC NGVAVRANQN LICDNLLPRR NLLLQTRLIN DVTSIRPNIF
     LGVAEGSAQY KKWYFELIID QVDPFLTAEP THLRVGWASS SGYAPYPGGG EGWGGNGVGD
     DLYSYGFDGL HLWSGRIPRA VASINQHLLR SDDVVSCCLD LGVPSISFRI NGQPVQGMFE
     NFNTDGLFFP VMSFSAGVKV RFLMGGRHGE FKFLPPSGYA PCYEALLPKE KMRLEPVKEY
     KRDADGVRDL LGTTQFLSQA SFIPCPIDTS QVVLPPHLEK IRDRLAENIH ELWGMNKIEL
     GWTFGKIRDD NKRQHPCLVE FSKLPETEKN YNLQMSTETL KTLLALGCHI AHVNPAAEED
     LKKVKLPKNY MMSNGYKPAP LDLSDVKLLP PQEILVDKLA ENAHNVWAKD RIKQGWTYGI
     QQDLKNKRNP RLVPYALLDE RTKKSNRDSL REAVRTFVGY GYNIEPSDQE LADSAVEKVS
     IDKIRFFRVE RSYAVRSGKW YFEFEVVTGG DMRVGWARPG CRPDVELGAD DQAFVFEGSR
     GQRWHQGSGY FGRTWQPGDV VGCMINLDDA SMIFTLNGEL LITNKGSELA FADYEIENGF
     VPICCLGLSQ IGRMNLGTDA STFKFYTMCG LQEGFEPFAV NMNRDVAMWF SKRLPTFVNV
     PKDHPHIEVM RIDGTMDSPP CLKVTHKTFG TQHSNADMIY CRLSMPVECH SSFSHSPCLD
     SEAFQKRKQM QEILSHTTTQ CYYAIRIFAG QDPSCVWVGW VTPDYHLYSE KFDLNKNCTV
     TVTLGDERGR VHESVKRSNC YMVWGGDIVA SSQKSNRSNV DLEIGCLVDL AMGMLSFSAN
     GKELGTCYQV EPNTKVFPAV FLQPTSTSLF QFELGKLKNA MPLSAAIFKS EEKNPVPQCP
     PRLDVQTIQP VLWSRMPNSF LKVESERVSE RHGWVVQCLE PLQMMALHIP EENRCVDILE
     LCEQEDLMRF HYHTLRLYSA VCALGNSRVA YALCSHVDLS QLFYAIDNKY LPGLLRAGFY
     DLLISIHLAN AKERKLMMKN EYIIPITSTT RNIRLFPDES KRHGLPGVGL RTCLKPGFRF
     STPCFVATGE EHQKQSPEIP LESLRTKALS MLTEAVQCSG AHIRDPVGGS VEFQFVPVLK
     LIGTLLVMGV FDDDDVRQIL LLIDPSVFGE HSADTEEGTE KEEVTQVEEK AVEAGEKAGK
     EAPVKGLLQT RLPESVKLQM CELLSYLCDC ELQHRVEAIV AFGDIYVSKL QANQKFRYNE
     LMQALNMSAA LTARKTKEFR SPPQEQINML LNFQLGENCP CPEELREELY DFHEDLLLHC
     GVPLEEEEEE EEDTSWTGKL RALVYKIKGP PKPEKEQPTE EEERCPTTLK ELISQTMICW
     AQEDQIQDAE LVRMMFNLLR RQYDSIGELL QALRKTYTIS HASVSDTINL LAALGQIRSL
     LSVRMGKEEE LLMINGLGDI MNNKVFYQHP NLMRVLGMHE TVMEVMVNVL STEKSQIAFP
     KMVASCCRFL CYFCRISRQN QKAMFEHLSY LLENSSVGLA SPSMRGSTPL DVAASSVMDN
     NELALGLEEP DLEKVVTYLA GCGLQSCPML LAKGYPDVGW NPIEGERYLS FLRFAVFVNS
     ESVEENASVV VKLLIRRPEC FGPALRGEGG NGLLAAMQGA IKISENPTLD LPSQGYKREV
     STEADEEEEE IVHMGNAIMS FYSALIDLLG RCAPEMHLIQ TGKGEAIRIR SILRSLVPTE
     DLVGIISIPL KLPSLNKDGS VSEPDMAANF CPDHKAPMVL FLDRVYGIKD QTFLLHLLEV
     GFLPDLRASA SLDTVSLSTT EAALALNRYI CSAVLPLLTR CAPLFAGTEH CTSLIDSTLQ
     TIYRLSKGRS LTKAQRDTIE ECLLAICNHL RPSMLQQLLR RLVFDVPQLN EYCKMPLKLL
     TNHYEQCWKY YCLPSGWGSY GLAVEEELHL TEKLFWGIFD SLSHKKYDPD LFRMALPCLS
     AIAGALPPDY LDTRITATLE KQISVDADGN FDPKPINTVN FSLPEKLEYI VTKYAEHSHD
     KWACDKSQSG WKYGISLDEN VKTHPLIRPF KTLTEKEKEI YRWPARESLK TMLAVGWTVE
     RTKEGEALVQ QRENEKLRSV SQANQGNSYS PAPLDLSNVV LSRELQGMVE VVAENYHNIW
     AKKKKLELES KGGGSHPLLV PYDTLTAKEK FKDREKAQDL FKFLQVNGVI VSRGMKDMEL
     DASSMEKRFA YKFLKKILKY VDSAQEFIAH LEAIVSSGKT EKSPHDQEIK FFAKVLLPLV
     DQYFTNHRLY FLSSPLKPLS SSGYASHKEK EMVASLFCKL AALVRHRISL FGSDSTTMVS
     CLHILAQTLD TRTVMKSGSE LVKAGLRAFF ENGAEDLEKT SENLKLGKFT HSRTQIQGVS
     QNVNYTTVAL LPILTSIFEH VAQHQFGMDL LLGDVQISCY HILCSLYSLG TGKNIYVERQ
     RPALGECLAS LAAAIPVAFL EPTLNRYNPL SVFNTKTPRE RSILGMPDTV EDMCPDIPQL
     EGLMKEINDL AESGARYTEV PHVIEVILPM LCNYLSYWWE RGPENLPPST GQCCTKVTSE
     HLSLILGNIL KIINNNLGID EASWMKRIAV YAQPIISKAR PDLLRSHFIP TLEKLKKKAV
     KTVQEEEQLR ADGKGDTQEA ELLILDEFAV LCRDLYAFYP MLIRYVDNNR SNWLKSPDAD
     SDQLFRMVAE VFILWCKSHN FKREEQNFVI QNEINNLAFL TGDSKSKMSK SGGQDQERKK
     TKRRGDLYSI QTSLIVAALK KMLPIGLNMC TPGDQELISL AKSRYGHRDT DEEVREHLRN
     NLHLQEKSDD PAVKWQLNLY KDVLKSEEPF NPEKTVERVQ RISAAVFHLE QVEQPLRSKK
     AVWHKLLSKQ RKRAVVACFR MAPLYNLPRH RSINLFLHGY QRFWIETEEY SFEEKLVQDL
     AKSPKVEEEE EEETEKQPDP LHQIILYFSR NALTERSKLE DDPLYTSYSS MMAKSCQSGE
     DEEADEDKEK TFEEKEMEKQ KTLYQQARLH ERGAAEMVLQ MISASKGEMS PMVVETLKLG
     IAILNGGNAG VQQKMLDYLK EKKDAGFFQS LSGLMQSCSV LDLNAFERQN KAEGLGMVTE
     EGTLIVRERG KFQFLNDEFT RDLFRFLQLL CEGHNSDFQN FLRTQMGNTT TVNVIISTVD
     YLLRLQESIS DFYWYYSGKD IIDESGQHNF SKALAVTKQI FNSLTEYIQG PCIGNQQSLA
     HSRLWDAVVG FLHVFANMQM KLSQDSSQIE LLKELLDLLQ DMVVMLLSLL EGNVVNGTIG
     KQMVDTLVES STNVEMILKF FDMFLKLKDL TSSDTFKEYD PDGKGIISKR EFQKAMEGQK
     QYTQSEIDFL LSCAEADEND MFNYIDFVDR FHEPAKDIGF NVAVLLTNLS EHMPNDSRLK
     CLLDPAESVL NYFEPYLGRI EIMGGAKKIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV
     VNEGGEQEKM ELFVNFCEDT IFEMQLASQI SESDSADRPE EEEEGEDSSY VLEIAGEEEE
     DGSFEPASAF AMACASVKRN VADFLKRATL KNLRKQYRNV KKMTAKELVK VLCSFFWMLF
     LGLFQMLFTI LGGIFQILWS TVFGGGLVEG AKNIRVTKIL GDMPDPTQFG IHDDTMEAER
     AEVMEPGITT ELVHFMKGEK GDTDIMSDLF GLHPKKEGSL KHGPEVGLGD LSEIIGKDEP
     PTLESTVQKK RKAQAAEMKA ANEAEGKVES EKADVEDGEK EDKDKEEEQA EYLWTEVTKK
     KKRRCGQKAE KPEAFTANFF KGLDIYQTKL LHYLARNFYN LRFLALFVAF AINFILLFYK
     VTEEPLEEET EDVANLWNSF NDEEEEEAMV FFVLQESTGY MAPTLRALAI IHTIISLVCV
     VGYYCLKVPL VVFKREKEIA RKLEFDGLYI TEQPSEDDIK GQWDRLVINT PSFPNNYWDK
     FVKRKVINKY GDLYGAERIA ELLGLDKNAL DFSPVEETKA EAASLVSWLS SIDMKYHIWK
     LGVVFTDNSF LYLAWYTTMS VLGHYNNFFF AAHLLDIAMG FKTLRTILSS VTHNGKQLVL
     TVGLLAVVVY LYTVVAFNFF RKFYNKSEDD DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD
     EIEDPAGDPY EMYRIVFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VREDMETKCF
     ICGIGNDYFD TTPHGFETHT LQEHNLANYL NKHPLFPLFQ ESYVWKMYQE RCWDFFPAGD
     CFRKQYEDQL G
//
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