GenomeNet

Database: UniProt
Entry: A0A1D5R0U3_MACMU
LinkDB: A0A1D5R0U3_MACMU
Original site: A0A1D5R0U3_MACMU 
ID   A0A1D5R0U3_MACMU        Unreviewed;      4941 AA.
AC   A0A1D5R0U3;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   05-DEC-2018, entry version 16.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSMMUP00000053926};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSMMUP00000053926};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000053926, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000053926, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000053926,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000053926}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000053926};
RG   Ensembl;
RL   Submitted (OCT-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; JSUE03003670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03003679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000074807; ENSMMUP00000053926; ENSMMUG00000001060.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000006718; Chromosome 1.
DR   ExpressionAtlas; A0A1D5R0U3; baseline.
DR   GO; GO:0034704; C:calcium channel complex; IBA:GO_Central.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4263   4282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4483   4503       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4557   4576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4684   4705       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4742   4763       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4818   4841       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       91    146       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      153    198       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      206    261       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      267    324       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      332    389       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      580    790       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1006   1203       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1318   1543       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4006   4041       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      453    473       {ECO:0000256|SAM:Coils}.
FT   COILED     3039   3059       {ECO:0000256|SAM:Coils}.
FT   COILED     3306   3326       {ECO:0000256|SAM:Coils}.
FT   COILED     4395   4428       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4941 AA;  561444 MW;  80B069D295DA31CF CRC64;
     LHDDEVVLQC TATIHKEQQK LCLAAEGFGN RLCFLESTSN SKNVPPDLSI CTFVLEQSLS
     VRALQEMLAN TVEKSEGQVD VEKWTAQGGG HRTLLYGHAI LLRHSYSGMY LCCLSTSRSS
     TDKLAFDVGL QEDTTGEACW WTIHPASKQR SEGEKVRVGD DLILVSVSSE RYLHLSYGNG
     SLHVDAAFQQ TLWSVAPISS GSEAAQGYLI GGDVLRLLHG HMDECLTVPS GEHGEEQRRT
     VHYEGGAVSV HARSLWRLET LRVAWSGSHI RWGQPFRLRH VTTGKYLSLM EDKNLLLMDK
     EKADVKSTAF TFRSSKEKLD VGVRKEVDGM GTSEIKYGDS VCYIQHVDTG LWLTYQSVDV
     KSVRMGSIQR KAIMHHEGHM DDGISLSRSQ HEESRTARVI RSTVFLFNRF IRGLDALSKK
     AKATTVDLPI ESVSLSLQDL IGYFHPPDEH LEHEDKQNRL RALKNRQNLF QEEGMINLVL
     ECIDRLHVYS SAAHFADVAG REAGESWKSI LNSLYELLAA LIRGNRKNCA QFSGSLDWLI
     SRLERLEASS GILEVLHCVL VESPEALNII KEGHIKSIIS LLDKHGRNHK VLDVLCSLCV
     CHGVAVRSNQ HLICDNLLPG RDLLLQTRLV NHVSSMRPNI FLGVSEGSAQ YKKWYYELMV
     DHTEPFVTAE ATHLRVGWAS TEGYSPYPGG GEEWGGNGVG DDLFSYGFDG LHLWSGCIAR
     TVSSPNQHLL RTDDVISCCL DLSAPSISFR INGQPVQGMF ENFNIDGLFF PVVSFSAGIK
     VRFLLGGRHG EFKFLPPPGY APCYEAVLPK EKLKVEHSRE YKQERTYTRD LLGPTVSLTQ
     AAFTPIPVDT SQIVLPPHLE RIREKLAENI HELWVMNKIE LGWQYGPVRD DNKRQHPCLV
     EFSKLPEQER NYNLQMSLET LKTLLALGCH VGISDEHAED KVKKMKLPKN YQLTSGYKPA
     PMDLSFIKLT PSQEAMVDKL AENAHNVWAR DRIRQGWTYG IQQDVKNRRN PRLVPYTLLD
     DRTKKSNKDS LREAVRTLLG YGYNLEAPDQ DHAARAEVCS GTGERFRIFR AEKTYAVKAG
     RWYFEFETVT AGDMRVGWSR PGCQPDQELG SDERAFAFDG FKAQRWHQGN EHYGRSWQAG
     DVVGCMVDMN EHTMMFTLNG EILLDDSGSE LAFKDFDVGD GFIPVCSLGV AQVGRMNFGK
     DVSTLKYFTI CGLQEGYEPF AVNTNRDITM WLSKRLPQFL QVPSNHEHIE VTRIDGTIDS
     SPCLKVTQKS FGSQNSHTDI MFYRLSMPIE CAEVFSKTVA GGLPGAGLFG PKNDLEDYDA
     DSDFEVLMKT AHGHLVPDRV DKDKEATKPE FNNHKDYAQE KPSRLKQRFL LRRTKPDYST
     SHSARLTEDV LADDRDDYDF LMQTSTYYYS VRIFPGQEPA NVWVGWITSD FHQYDTGFDL
     DRVRTVTVTL GDEKGKVHES IKRSNCYMVC AGESMSPGQG RNNNGLEIGC VVDAASGLLT
     FIANGKELST YYQVEPSTKL FPAVFAQATS PNVFQFELGR IKNVMPLSAG LFKSEHKNPV
     PQCPPRLHVQ FLSHVLWSRM PNQFLKVDVS RISERQGWLV QCLDPLQFMS LHIPEENRSV
     DILELTEQEE LLKFHYHTLR LYSAVCALGN HRVAHALCSH VDEPQLLYAI ENKYMPGLLR
     AGYYDLLIDI HLSSYATARL MMNNEYIVPM TEETKSITLF PDENKKHGLP GIGLSTSLRP
     RMQFSSPSFV SVSNECYQYS PEFPLDILKA KTIQMLTEAV KEGSLHARDP VGGTTEFLFV
     PLIKLFYTLL IMGIFHNEDL KHILQLIEPS VFKEAATPEE ESDTLEKELS VDDAKLQGAG
     EEEAKGGKRP KEGLLQMKLP EPVKLQMCLL LQYLCDCQVR HRIEAIVAFS DDFVAKLQDN
     QRFRYNEVMQ ALNMSAALTA RKTKEFRSPP QEQINMLLNF KDDKSECPCP EEIRDQLLDF
     HEDLMTHCGI ELDEDGSLDG NSDLTIRGRL LSLVEKVTYL KKKQAEKPVE SDSKKSSTLQ
     QLISETMVRW AQESVIEDPE LVRAMFVLLH RQYDGIGGLV RALPKTYTIN GVSVEDTINL
     LASLGQIRSL LSVRMGKEEE KLMIRGLGDI MNNKVFYQHP NLMRALGMHE TVMEVMVNVL
     GGGESKEITF PKMVANCCRF LCYFCRISRQ NQKAMFDHLS YLLENSSVGL ASPAMRGSTP
     LDVAAASVMD NNELALALRE PDLEKVVRYL AGCGLQSCQL LVSKGYPDIG WNPVEGERYL
     DFLRFAVFCN GESVEENANV VVRLLIRRPE CFGPALRGEG GNGLLAAMEE AIKIAEDPSR
     DGPSPNSGSS KTLDTEEEED DTIHMGNAIM TFYAALIDLL GRCAPEMHLI HAGKGEAIRI
     RSILRSLIPL GDLVGVISIA FQMPTIAKDG NVVEPDMSAG FCPDHKAAMV LFLDRVYGIE
     VQDFLLHLLE VGFLPDLRAA ASLDTAALSA TDMALALNRY LCTAVLPLLT RCAPLFAGTE
     HHASLIDSLL HTVYRLSKGC SLTKAQRDSI EVCLLSICGQ LRPSMMQHLL RRLVFDVPLL
     NEHAKMPLKL LTNHYERCWK YYCLPGGWGN FGAASEEELH LSRKLFWGIF DALSQKKYEQ
     ELFKLALPCL SAVAGALPPD YMESNYVSMM EKQSSMDSEG NFNPQPVDTS NITIPEKLEY
     FINKYAEHSH DKWSMDKLAN GWIYGEIYSD SSKVQPLMKP YKLLSEKEKE IYRWPIKESL
     KTMLAWGWRI ERTREGDSMA LYNRTRRISQ TSQVSVDAAH GYSPRAIDMS NVTLSRDLHA
     MAEMMAENYH NIWAKKKKME LESKGGGNHP LLVPYDTLTA KEKAKDREKA QDILKFLQIN
     GYAVSRGFKD LELDTPSIEK RFAYSFLQQL IRYVDEAHQY ILEFDGGSRG KGEHFPYEQE
     IKFFAKVVLP LIDQYFKNHR LYFLSAASRP LCSGGHASNK EKEMVTSLFC KLGVLVRHRI
     SLFGNDATSI VNCLHILGQT LDARTVMKTG LESVKSALRA FLDNAAEDLE KTMENLKQGQ
     FTHTRNQPKG VTQIINYTTV ALLPMLSSLF EHIGQHQFGE DLILEDVQVS CYRILTSLYA
     LGTSKSIYVE RRRSQLKACQ ILLSFEVQNA IVACGNLPYH LSTFFEYNPF FMCTSPALSL
     PTNVEDVCPN IPSLEKLMEE IVELAESGIR YTQMPHVMEV ILPMLCSYMS RWWEHGPENN
     PERAEMCCTA LNSEHMNTLL GNILKIIYNN LGIDEGAWMK RLAVFSQPII NKVKPQLLKT
     HFLPLMEKLK KKAAMVVSEE DHLKAEARGD MSEAELLILD EFTTLARDLY AFYPLLIRFV
     DYNRAKWLKE PNPEAEELFR MVAEVFIYWS KSHNFKREEQ NFVVQNEINN MSFLITDTKS
     KMSKAAVSDQ ERKKMKRKGD RYSMQTSLIV AALKRLLPIG LNICAPGDQE LIALAKNRFS
     LKDTEDEVRD IIRSNIHLQG KLEDPAIRWQ MALYKDLPNR TDDTSDPEKT VERVLDIANV
     LFHLEQVRLC VNSVIFALVE HPQRSKKAVW HKLLSKQRKR AVVACFRMAP LYNLPRHRAV
     NLFLQGYEKS WIETEEHYFE DKLIEDLAKP GADPPEEDEG TKRVDPLHQL ILLFSRTALT
     EKCKLEEDFL YMAYADIMAK SCHDEEDDDG EEEVKSFEEK EMEKQKLLYQ QARLHDRGAA
     EMVLQTISAS KGETGPMVAA TLKLGIAILN GGNSTVQQKM LDYLKEKKDV GFFQSLAGLM
     QSCSVLDLNA FERQNKAEGL GMVTEEGSGE KVLQDDEFTC DLFRFLQLLC EGHNSDFQNY
     LRTQTGNNTT VNIIISTVDY LLRVQESISD FYWYYSGKDV IDEQGQRNFS KAIQVAKQVF
     NTLTEYIQGP CTGNQQSLAH SRLWDAVVGF LHVFAHMQMK LSQDSSQIEL LKELMDLQKD
     MVVMLLSMLE GNVVNGTIGK QMVDMLVESS NNVEMILKFF DMFLKLKDLT SSDTFKEYDP
     DGKGVISKRD FHKAMESHKH YTQSETEFLL SCAETDENET LDYEEFVKRF HEPAKDIGFN
     VAVLLTNLSE HMPNDTRLQT FLELAESVLN YFQPFLGRIE IMGSAKRIER VYFEISESSR
     TQWEKPQVKE SKRQFIFDVV NEGGEKEKME LFVNFCEDTI FEMQLAAQIS ESDLNERSAN
     KEESEKERPE EQGPRMAFFS ILTVKSALFA LRYNILTLMR MLSLKSLKKQ MKKVKKMTVK
     DMVTAFFSSY WSIFMTLLHF VASVFRGFFR IICSLLLGGS LVEGAKKIKV AELLANMPDP
     TQDEVRGDGE EGERKTLEAA LPSEDLTDLK ELTEESDLLS DIFGLDLKRE GGQYKLIPHN
     PNAGLSDLMS NPVPMPEVQE KFQEQKAKEE EKEEKEETKS EPEKAEGEDG EKEEKAKEDK
     GKQKLRQLHT HRYGEPEVPE SAFWKKIIAY QQKLLNYFAR NFYNMRMLAL FVAFAINFIL
     LFYKVSTSSV VEGKELPTRS SSENAKVTSL DSSSHRIIAV HYVLEESSGY MEPTLRILAI
     LHTVISFFCI IGYYCLKVPL VIFKREKEVA RKLEFDGLYI TEQPSEDDIK GQWDRLPIKC
     FFSYPKVMDK YGEFYGRDRI SELLGMDKAA LDFSDAREKK KPKKDSSLSA VLNSIDVKYQ
     MWKLGVVFTD NSFLYLAWYM TMSVLGHYNN FFFAAHLLDI AMGFKTLRTI LSSVTHNGKQ
     LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDGDTPDMKC DDMLTCYMFH MYVGVRAGGG
     IGDEIEDPAG DEYEIYRIIF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ QEQVKEDMET
     KCFICGIGND YFDTVPHGFE THTLQEHNLA NYLFFLMYLI NKDETEHTGQ ESYVWKMYQE
     RCWEFFPAGD CFRKQYEDQL N
//
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