ID A0A1D5R472_MACMU Unreviewed; 609 AA.
AC A0A1D5R472;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=AarF domain containing kinase 2 {ECO:0000313|Ensembl:ENSMMUP00000055108.2};
GN Name=ADCK2 {ECO:0000313|Ensembl:ENSMMUP00000055108.2,
GN ECO:0000313|VGNC:VGNC:69473};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000055108.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000055108.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000055108.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC kinase family. {ECO:0000256|ARBA:ARBA00009670}.
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DR AlphaFoldDB; A0A1D5R472; -.
DR Ensembl; ENSMMUT00000069295.2; ENSMMUP00000055108.2; ENSMMUG00000015282.4.
DR VEuPathDB; HostDB:ENSMMUG00000015282; -.
DR VGNC; VGNC:69473; ADCK2.
DR GeneTree; ENSGT00390000001536; -.
DR Proteomes; UP000006718; Chromosome 3.
DR Bgee; ENSMMUG00000015282; Expressed in dorsolateral prefrontal cortex and 20 other cell types or tissues.
DR ExpressionAtlas; A0A1D5R472; baseline and differential.
DR CDD; cd13971; ADCK2-like; 1.
DR InterPro; IPR004147; ABC1_dom.
DR InterPro; IPR044095; ADCK2_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR45890; AARF DOMAIN CONTAINING KINASE 2 (PREDICTED); 1.
DR PANTHER; PTHR45890:SF25; AARF DOMAIN-CONTAINING KINASE 2; 1.
DR Pfam; PF03109; ABC1; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 169..218
FT /note="ABC1 atypical kinase-like"
FT /evidence="ECO:0000259|Pfam:PF03109"
FT DOMAIN 291..526
FT /note="ABC1 atypical kinase-like"
FT /evidence="ECO:0000259|Pfam:PF03109"
SQ SEQUENCE 609 AA; 66884 MW; 964898946A383B7F CRC64;
MVAPWRVSVR VCLSHLRCFE LRQGLSLLRP SECPRDARLC WLLLGTLPKV VSVCGDVGEG
ATDVLGRQRV RCSAAAGAGL AESLPRAGPL GGVFLHLRLW LRAGALLVKF FPLLLLYPLT
YLAPSVSTLW LHLLLKATET SGPTYIKLGQ WASTRRDLFS EAFCAQFSKL HVRVTPHPWA
HTERFLRQAF GEDWGSILSF ENREPVGSGC VAQVYKAYAN TAFLETDSVQ RLGRASCLPP
FPDAGAVGGL RELFGYLGNG RKPPGNLADQ SFLERLLLPE ADLVGSNAGV SQAQVPGHQL
EPGHLIPVAV KVLHPGLLAQ VHMDLLLMKI GSRVLGLLPG IKWLSLPEIV EEFEKLMVQQ
IDLRYEAQNL EHFQVNFQNV KAVKFPTPLR PFVTREVLVE TYEESVPVSS YQQAGIPVDL
KRKIARLGIN MLLKMIFVDN FVHADLHPGN ILVQGADSLS SSREAQLQQA DVCDTLVVAV
PSSLCPLRLV LLDAGIVAEL QASDLRNFRA VFMAVVMGQG QRVAELILHH ARASECRDVE
GFKTEMATLV TQARKNTITL EKVGRLLAEQ GPGCPYLAWG RADPGSKGDL FMRGVSVKAK
KEPPHIFQA
//
