ID A0A1D5R6Z6_MACMU Unreviewed; 1169 AA.
AC A0A1D5R6Z6;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Zinc finger protein 862 {ECO:0000313|Ensembl:ENSMMUP00000056084.2};
GN Name=ZNF862 {ECO:0000313|Ensembl:ENSMMUP00000056084.2,
GN ECO:0000313|VGNC:VGNC:79951};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000056084.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000056084.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000056084.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; A0A1D5R6Z6; -.
DR STRING; 9544.ENSMMUP00000056084; -.
DR Ensembl; ENSMMUT00000073991.2; ENSMMUP00000056084.2; ENSMMUG00000011122.4.
DR VEuPathDB; HostDB:ENSMMUG00000011122; -.
DR VGNC; VGNC:79951; ZNF862.
DR GeneTree; ENSGT00940000162620; -.
DR InParanoid; A0A1D5R6Z6; -.
DR OMA; DQACVGI; -.
DR Proteomes; UP000006718; Chromosome 3.
DR Bgee; ENSMMUG00000011122; Expressed in cerebellar cortex and 22 other cell types or tissues.
DR ExpressionAtlas; A0A1D5R6Z6; baseline and differential.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 2.
DR Gene3D; 6.10.140.140; -; 2.
DR InterPro; IPR008906; HATC_C_dom.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR006580; Znf_TTF.
DR PANTHER; PTHR46880; RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46880:SF3; ZINC FINGER PROTEIN 862; 1.
DR Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR Pfam; PF01352; KRAB; 2.
DR SMART; SM00349; KRAB; 2.
DR SMART; SM00597; ZnF_TTF; 2.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50805; KRAB; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 11..77
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 333..404
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT COILED 758..785
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1169 AA; 131011 MW; 0F449F9B049AB4AC CRC64;
MEPRESGKAP VTFDDITVYL LQEEWVLLSQ QQKELCGSDK LVAPLGPTVA NPELFCKFGP
GPEPWLGSVQ GQRSHLEHHP GKKQMGYMED MGVQGPTRES GQSLPPKKKA RLSHLSTCSG
HIEGDWAGRN RKLLKPRSIQ KSWFVQFPWL TMNEEQTALF CSACREYPSI RDKRSRLIEG
YTGPFKVETL KYHAKSKAHM FCVDALAARD PIWAARFRSI RDPSGDVLAS PEPLFTADYP
IFYPPGPLGG FDSMAELLPS SRAELEDPGG NGAIPAMYLD CISDLRQKEV TDGIHSSSDI
DILCNDAVES CIQDPSAEGL SEEVPVVFEE LPVVFEDVAV YFTRKEWGML DKRQKELYRD
VMRMNYELLA SLGPAAAKPD LISKLERRAA PWIKDPNGPK WGKGRPPGNK KMVAVRETDT
QALAADSALL PASPVEAHAS CCSPSICEGE GDGPRRIKRT YRPRSIQRSW FGQFPWLVID
PKETKLFCSA CKERPNLHDK SSRLVRGYTG PFKVETLKYH EVSKAHRLCV NTVEIKEDTP
HTALIPEISS DLMANMEHFF NAAYSIAYHS RPLNDFEKIL QLLQSTGTMI LGKYRNRTAC
TQFIKYISET LKREILEDVR NSPCVSVLLD SSTDASEQAC VGIYIRYFKQ MEVKESYITL
APLCSETADG YFETIVSALD ELDIPFRKPG WVVGLGTDGS AMLSCRGGLV EKFQEVIPQL
LPVHCVAHQL HLAVVDACGS IDLVKKCDRH IRTVFKFYQS SNKRLNELQE GAASLEQEII
RLKDLNAVRW VASRRRTLHA LLGSWPALAR HLQSVAEAGG QIGHRAKGML KLMRGFHFVK
FCHFLLDFLS VYRPLSEVCQ KEIVLITEVN ATLGRAYVAL ESLRHQAGPK EEEFNASFKD
GRLHGICLDG LEVAEQRFQA DREKTVLTGI EYLQQRFDAD RPPQLKNMEV FDTMAWPSGI
ELASFGNDDI LTLARYFECS LPTGYSEEAL LEEWLGLKAI AQHLPFSMLC KNALAQHCRF
PLLSKLMAVV VCVPISTSCC ERGFKAMNRI RTDERTKLSN EVLNMLMMTA VNGVAVTEYD
PQPAIQHWFL TSSGRRFSHV YACAQVPARS PASARPRKEE MGALYVESGS QKPPIVPSRA
AVEVLKDCIM EPPERLLYPH TSQEAPGMS
//
