ID A0A1D5RGD3_MACMU Unreviewed; 519 AA.
AC A0A1D5RGD3;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=TUB like protein 2 {ECO:0000313|Ensembl:ENSMMUP00000059377.2};
GN Name=TULP2 {ECO:0000313|Ensembl:ENSMMUP00000059377.2,
GN ECO:0000313|VGNC:VGNC:111179};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000059377.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000059377.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000059377.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129}.
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DR AlphaFoldDB; A0A1D5RGD3; -.
DR SMR; A0A1D5RGD3; -.
DR STRING; 9544.ENSMMUP00000059377; -.
DR Ensembl; ENSMMUT00000076712.2; ENSMMUP00000059377.2; ENSMMUG00000048854.2.
DR VEuPathDB; HostDB:ENSMMUG00000048854; -.
DR VGNC; VGNC:111179; TULP2.
DR GeneTree; ENSGT00940000161908; -.
DR InParanoid; A0A1D5RGD3; -.
DR OMA; EQQWRLF; -.
DR Proteomes; UP000006718; Chromosome 19.
DR Bgee; ENSMMUG00000048854; Expressed in testis and 18 other cell types or tissues.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR018066; Tubby_C_CS.
DR InterPro; IPR005398; Tubby_N.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR PANTHER; PTHR16517:SF24; TUBBY-RELATED PROTEIN 2; 1.
DR Pfam; PF01167; Tub; 1.
DR Pfam; PF16322; Tub_N; 1.
DR PRINTS; PR01573; SUPERTUBBY.
DR PRINTS; PR01574; TUBBYPROTEIN.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR PROSITE; PS01200; TUB_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 27..246
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 276..517
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 129..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 10..42
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 168..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 59060 MW; 382315CC02ACE2C4 CRC64;
MSQDDDTLRR DILEHELAAM RLQKLEQQRR LFEKKQRQKR QELFMVQANP DASLWLWRSC
LREERLLGDR GLRNPFLRKK VSEAHLPSGI HSALGTVSCG GDGRGEHGLL TPRTEAVFRN
LGLQSPFSSW LPDNSDPELE EVSVENGSVS PPPFKQSPRI RRKGWQARQR PTRAEGESES
QDVGDAYKAP SMGPNPGMDG DWVYENLAFY KEEDLEKKRE ASESTGPNSA AANEELFEAL
KGEGGTDSDH MRQEASLAIR SPCPRLQEDM EAYVLRPAVP GTRMQCYLTR DRRGVDKGLF
PLYYLYLETS DSLKHFLLAG RKRRRSKTSN YLISLDPTDL SRDGDNFVGK VRSNIFGTKF
TIFDNGVNPD REHLIKNTAR IRRELGAVCY EPNILGYLGP RKMTAILPGT NSQNQRIDVQ
PRNEQESLLS RYQRGEKQGL LLLHSKTPSW NKENGVYTLN FHGRVTRASV KNFQIVDPKH
PEHLVLQFGR VGPDTFTMDF CFPFSPLQAF GVCLSSFSW
//
