ID A0A1D5RLK2_MOUSE Unreviewed; 1035 AA.
AC A0A1D5RLK2;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Pleckstrin and Sec7 domain containing 3 {ECO:0000313|Ensembl:ENSMUSP00000148401.2};
GN Name=Psd3 {ECO:0000313|Ensembl:ENSMUSP00000148401.2,
GN ECO:0000313|MGI:MGI:1918215};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000148401.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:15345747}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [2] {ECO:0007829|PubMed:16452087}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [3] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000148401.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148401.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6] {ECO:0000313|Ensembl:ENSMUSP00000148401.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148401.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
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DR AlphaFoldDB; A0A1D5RLK2; -.
DR SMR; A0A1D5RLK2; -.
DR jPOST; A0A1D5RLK2; -.
DR ProteomicsDB; 355756; -.
DR Antibodypedia; 9043; 161 antibodies from 22 providers.
DR Ensembl; ENSMUST00000212505.2; ENSMUSP00000148401.2; ENSMUSG00000030465.20.
DR AGR; MGI:1918215; -.
DR MGI; MGI:1918215; Psd3.
DR VEuPathDB; HostDB:ENSMUSG00000030465; -.
DR GeneTree; ENSGT00940000156591; -.
DR ChiTaRS; Psd3; mouse.
DR Proteomes; UP000000589; Chromosome 8.
DR Bgee; ENSMUSG00000030465; Expressed in subiculum and 237 other cell types or tissues.
DR ExpressionAtlas; A0A1D5RLK2; baseline and differential.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF337; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:A0A1D5RLK2,
KW ECO:0007829|PeptideAtlas:A0A1D5RLK2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 529..721
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 772..885
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 37..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1035
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1035 AA; 114536 MW; 46CF08FF92CBE7D9 CRC64;
MEGRNAAAEP FVWVNSASAH SQSVAKAKYE FLFGKSEEKT PDSSDHGGST LLPPTVTNEF
PEYGTMEEGG EGLRASLDFD AKSPPCRLPG QQAVHLLAGQ DSILNSVTEG PNDAPQCHPQ
EQSLQPIDSL ISALKATEAR IASGTFQATK VLDKDANFSV YQVDKELSTA SHKPQRAHRT
FPVGPGKSPD IPLSAEVPTE ENLSLHIQED LSALLPEEAQ AHRSQITNYR RQGPLRVPES
ACPVSSSSAG SHNPVDRVGA LREQRSDLGR EHPRGYDRGG SMGRQGRIKH VEFQGVEILW
TGEEAESRHP PERTASPVSK EFAKRPSHSS PACGVCSTST HLTGDVWDET CKAPSERPGT
SAGTLSPMPL GESGEDDVFL RESKEHLEEN FAIQGDKERI LDQEEHLRGD DDILGPGYTE
DSTDVYSSQF ETILDNTSLY YSAESLETLY SEPDSYFSFE MPLTPMIQQR IKEGGQFLER
TSVGGQHDVL SVSADGGIVM GYSAGITNGL HDSANSVYTR GPQEIAFWGR DRCFAEGKTT
GVDAGSEMGS TDILEKETTE SLSNGTNSNV EAAKRLAKRL YHLDRFKRSD VAKHLGKNNE
FSKLVAEEYL KFFDFTGMTL DQSLRYFLKA FSLVGETQER ERVLIHFSNR YFSCNPDTIT
SKDGVHCLTC AMMLLNTDLH GHNIGKKMTC QEFITNLQGV NEGGDFSKDL LKALYNSIKN
EKLEWAVDDE EKKKSPSEGT DEKANGTHPK TISRIGSTTN PFLDIPHDPN AAVYKSGFLA
RKIHADMDGK KTPRGKRGWK TFYAVLKGTV LYLQKDEYKP EKSLSDEDLK NAVSVHHALA
SKATDYEKKP NVFKLKTADW RVLLFQTQSP EEMQGWINKI NCVAAVFSAP PFPAAIGSQK
KFSRPLLPAT TTKLSQEEQL KSHESKLKQI TTELAEHRSY PPDKKVKAKD VDEYKLKDHY
LEFEKTRYEI YVSVLKEGGK ELLTTDGNEP VGLKKSHSSP SLNPDASPVT AKVKRNVSER
KDHRPETPGI KQKVT
//
