ID A0A1D5RLU5_MOUSE Unreviewed; 74 AA.
AC A0A1D5RLU5;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=LITAF domain containing {ECO:0000313|Ensembl:ENSMUSP00000148509.2};
GN Name=Litafd {ECO:0000313|Ensembl:ENSMUSP00000148509.2,
GN ECO:0000313|MGI:MGI:3643507};
GN Synonyms=Gm5767 {ECO:0000313|MGI:MGI:3643507};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000148509.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000148509.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148509.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000148509.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148509.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004630}.
CC -!- SIMILARITY: Belongs to the CDIP1/LITAF family.
CC {ECO:0000256|ARBA:ARBA00005975}.
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DR AlphaFoldDB; A0A1D5RLU5; -.
DR Ensembl; ENSMUST00000202157.2; ENSMUSP00000148509.2; ENSMUSG00000107252.2.
DR AGR; MGI:3643507; -.
DR MGI; MGI:3643507; Litafd.
DR VEuPathDB; HostDB:ENSMUSG00000107252; -.
DR GeneTree; ENSGT00940000163474; -.
DR Proteomes; UP000000589; Chromosome 16.
DR Bgee; ENSMUSG00000107252; Expressed in testis and 33 other cell types or tissues.
DR ExpressionAtlas; A0A1D5RLU5; baseline and differential.
DR GO; GO:0098560; C:cytoplasmic side of late endosome membrane; IBA:GO_Central.
DR GO; GO:0098574; C:cytoplasmic side of lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR InterPro; IPR006629; LITAF.
DR InterPro; IPR037519; LITAF_fam.
DR PANTHER; PTHR23292; LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR; 1.
DR PANTHER; PTHR23292:SF45; LITAF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF10601; zf-LITAF-like; 1.
DR PROSITE; PS51837; LITAF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 28..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..73
FT /note="LITAF"
FT /evidence="ECO:0000259|PROSITE:PS51837"
SQ SEQUENCE 74 AA; 8005 MW; 00088F44FE91AE08 CRC64;
MPTSIPVQAV CPYCGNRIMT VTTYTPGLLT WLLCSGLFVF GSPSLLLPRN RGLSIALSPA
LENCPQRTET HAEV
//
