ID A0A1D5RM43_MOUSE Unreviewed; 232 AA.
AC A0A1D5RM43;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Y+L amino acid transporter 2 {ECO:0000256|ARBA:ARBA00039563};
DE AltName: Full=Solute carrier family 7 member 6 {ECO:0000256|ARBA:ARBA00042899};
DE AltName: Full=y(+)L-type amino acid transporter 2 {ECO:0000256|ARBA:ARBA00042001};
DE Flags: Fragment;
GN Name=Slc7a6 {ECO:0000313|Ensembl:ENSMUSP00000148620.2,
GN ECO:0000313|MGI:MGI:2142598};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000148620.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:19144319}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000148620.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148620.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000148620.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148620.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-cysteine(out) + Na(+)(out) = L-
CC arginine(out) + L-cysteine(in) + Na(+)(in); Xref=Rhea:RHEA:70847,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:35235;
CC Evidence={ECO:0000256|ARBA:ARBA00036855};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-glutamine(out) + Na(+)(out) = L-
CC arginine(out) + L-glutamine(in) + Na(+)(in); Xref=Rhea:RHEA:70835,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:58359;
CC Evidence={ECO:0000256|ARBA:ARBA00036315};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-histidine(out) + Na(+)(out) = L-
CC arginine(out) + L-histidine(in) + Na(+)(in); Xref=Rhea:RHEA:70839,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:57595;
CC Evidence={ECO:0000256|ARBA:ARBA00036477};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out)
CC + L-leucine(in) + Na(+)(in); Xref=Rhea:RHEA:70831, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:32682, ChEBI:CHEBI:57427;
CC Evidence={ECO:0000256|ARBA:ARBA00036563};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-lysine(out) = L-arginine(out) + L-
CC lysine(in); Xref=Rhea:RHEA:70827, ChEBI:CHEBI:32551,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000256|ARBA:ARBA00036987};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-methionine(out) + Na(+)(out) = L-
CC arginine(out) + L-methionine(in) + Na(+)(in); Xref=Rhea:RHEA:70843,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:57844;
CC Evidence={ECO:0000256|ARBA:ARBA00035819};
CC -!- SUBUNIT: Disulfide-linked heterodimer with the amino acid transport
CC protein SLC3A2/4F2hc. {ECO:0000256|ARBA:ARBA00038768}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC {ECO:0000256|ARBA:ARBA00007040}.
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DR AlphaFoldDB; A0A1D5RM43; -.
DR SMR; A0A1D5RM43; -.
DR ProteomicsDB; 351687; -.
DR Antibodypedia; 55124; 122 antibodies from 18 providers.
DR Ensembl; ENSMUST00000211824.2; ENSMUSP00000148620.2; ENSMUSG00000031904.6.
DR AGR; MGI:2142598; -.
DR MGI; MGI:2142598; Slc7a6.
DR VEuPathDB; HostDB:ENSMUSG00000031904; -.
DR GeneTree; ENSGT00940000158295; -.
DR ChiTaRS; Slc7a6; mouse.
DR Proteomes; UP000000589; Chromosome 8.
DR Bgee; ENSMUSG00000031904; Expressed in spermatocyte and 246 other cell types or tissues.
DR ExpressionAtlas; A0A1D5RM43; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR PANTHER; PTHR11785; AMINO ACID TRANSPORTER; 1.
DR PANTHER; PTHR11785:SF398; Y+L AMINO ACID TRANSPORTER 2; 1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:A0A1D5RM43,
KW ECO:0007829|MaxQB:A0A1D5RM43};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022970}.
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT NON_TER 232
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000148620.2"
SQ SEQUENCE 232 AA; 24984 MW; 507BE718B6E31802 CRC64;
MEAQELGSPT PTYHLLPKAN QHTVKEDAGS PSQGSPETMQ LKKEISLLNG VSLVVGNMIG
SGIFVSPKGV LKYTASYGLS LIVWAIGGLF SVVGALCYAE LGTTITKSGA SYAYILEAFG
GFIAFIRLWV SLLIVEPTSQ AIIAITFANY IIKPSFPTCD PPYVACRLLA AACVCLLTFV
NCAYVKWGTR VQDTFTYAKV LALIAIIIMG LVKLCQGWDT LNFVTEEIKN PE
//
