ID A0A1D5RMC2_MOUSE Unreviewed; 672 AA.
AC A0A1D5RMC2;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Zinc finger protein 612 {ECO:0000313|Ensembl:ENSMUSP00000148717.2};
GN Name=Zfp612 {ECO:0000313|Ensembl:ENSMUSP00000148717.2,
GN ECO:0000313|MGI:MGI:2443465};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000148717.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000148717.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148717.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000148717.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148717.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR RefSeq; NP_780689.3; NM_175480.4.
DR RefSeq; XP_006530975.1; XM_006530912.3.
DR AlphaFoldDB; A0A1D5RMC2; -.
DR SMR; A0A1D5RMC2; -.
DR STRING; 10090.ENSMUSP00000148717; -.
DR PaxDb; 10090-ENSMUSP00000062474; -.
DR ProteomicsDB; 337400; -.
DR Antibodypedia; 16582; 197 antibodies from 30 providers.
DR DNASU; 234725; -.
DR Ensembl; ENSMUST00000212754.2; ENSMUSP00000148717.2; ENSMUSG00000044676.11.
DR GeneID; 234725; -.
DR KEGG; mmu:234725; -.
DR AGR; MGI:2443465; -.
DR CTD; 234725; -.
DR MGI; MGI:2443465; Zfp612.
DR VEuPathDB; HostDB:ENSMUSG00000044676; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162377; -.
DR InParanoid; A0A1D5RMC2; -.
DR OMA; NAKLIWH; -.
DR OrthoDB; 4750812at2759; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 234725; 3 hits in 77 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; A0A1D5RMC2; Protein.
DR Bgee; ENSMUSG00000044676; Expressed in pontine nuclear group and 216 other cell types or tissues.
DR ExpressionAtlas; A0A1D5RMC2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 16.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24381; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24381:SF431; ZINC FINGER PROTEIN 78; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 9.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|ProteomicsDB:A0A1D5RMC2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 11..82
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 225..252
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 253..280
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 281..308
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 309..336
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 337..364
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 365..392
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 393..420
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 421..448
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 449..476
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 477..504
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 505..532
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 533..560
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 561..588
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 589..616
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 617..644
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 645..672
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 165..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 76133 MW; 2C10FFEDAB941BB0 CRC64;
MIPSVWPQKS VTFEDVAVYF TQTEWDGLSP GQRALYRDVM LENYRNLASV GFPLLKPAVI
SQLEERKDLE NLFQLATGTD SQGLWTECTA VQSGNNLTKE VHEEEKSTLF ELQKDFSQET
NFSKTYILGQ QQEIRSAGSE RGSASATDGR AKASSVEGCL FSQTPQLSQD HTSSTGELYS
DTKLSKSERI TTEERPLKPR ELAEASQGSP QVNQLPEICD VEKPYQCAEC GKAFSVKAKF
VWHQRLHNGE KPFKCVECGK CFSYSSHYIT HQTIHSGEKP YQCKVCGKAF SVNGSLVRHQ
RIHTGEKPYQ CKDCGAGFGC SSAYITHQRT HTGEKPYECS DCGKAFNVNA KLIQHQRIHT
GEKPYECDVC GKGFRCSTQL RQHQSIHTGE KPHRCSECGK GFTKNAKLIQ HQRVHTGEKP
YACSDCGKTF SAKGKLIQHQ RIHTGERPYE CSECGKSFRC NSQLRQHLRI HTGEKPYKCS
ECGKAFNVNA KLMQHRRTHT GEKPFECKEC GKCFTSKRNL LDHQRAHTGE KPYQCSECGK
AFSINAKLTR HQQIHTREKP FKCMECEKAF SCSSDYIVHQ RIHTGEKPFQ CGECGKAFHV
NAHLIRHQRS HTGEKPFRCT ECGKGFSLSS DCIIHQTVHT WKKPYVCNVC GKTFRFSFQL
SQHQDVHNED KS
//
