ID A0A1D5UPW5_WHEAT Unreviewed; 471 AA.
AC A0A1D5UPW5;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Serine hydroxymethyltransferase {ECO:0000256|RuleBase:RU000585};
DE EC=2.1.2.1 {ECO:0000256|RuleBase:RU000585};
GN ORFNames=CAMPLR22A2D_LOCUS4912 {ECO:0000313|EMBL:SPT20282.1},
GN CFC21_019322 {ECO:0000313|EMBL:KAF7004072.1}, CFC21_032041
GN {ECO:0000313|EMBL:KAF7018796.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS2D02G493600.1};
RN [1] {ECO:0000313|EMBL:KAF7004072.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7004072.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS2D02G493600.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS2D02G493600.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EMBL:SPT20282.1, ECO:0000313|Proteomes:UP000280104}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Thind KAUR A.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EnsemblPlants:TraesCS2D02G493600.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [5] {ECO:0000313|EMBL:KAF7004072.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7004072.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Interconversion of serine and glycine.
CC {ECO:0000256|RuleBase:RU000585}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O =
CC (6S)-5,6,7,8-tetrahydrofolate + L-serine; Xref=Rhea:RHEA:15481,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15636, ChEBI:CHEBI:33384,
CC ChEBI:CHEBI:57305, ChEBI:CHEBI:57453; EC=2.1.2.1;
CC Evidence={ECO:0000256|RuleBase:RU000585};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR000412-50, ECO:0000256|RuleBase:RU000585};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU000585}.
CC -!- SIMILARITY: Belongs to the SHMT family. {ECO:0000256|ARBA:ARBA00006376,
CC ECO:0000256|RuleBase:RU000585}.
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DR EMBL; CM022214; KAF7004072.1; -; Genomic_DNA.
DR EMBL; CM022216; KAF7018796.1; -; Genomic_DNA.
DR EMBL; LS480641; SPT20282.1; -; Genomic_DNA.
DR SMR; A0A1D5UPW5; -.
DR STRING; 4565.A0A1D5UPW5; -.
DR EnsemblPlants; TraesCS2A02G493700.1; TraesCS2A02G493700.1; TraesCS2A02G493700.
DR EnsemblPlants; TraesCS2D02G493600.1; TraesCS2D02G493600.1; TraesCS2D02G493600.
DR Gramene; TraesCAD_scaffold_014883_01G000200.1; TraesCAD_scaffold_014883_01G000200.1; TraesCAD_scaffold_014883_01G000200.
DR Gramene; TraesCAD_scaffold_034592_01G000200.1; TraesCAD_scaffold_034592_01G000200.1; TraesCAD_scaffold_034592_01G000200.
DR Gramene; TraesCLE_scaffold_022869_01G000400.1; TraesCLE_scaffold_022869_01G000400.1; TraesCLE_scaffold_022869_01G000400.
DR Gramene; TraesCLE_scaffold_034604_01G000200.1; TraesCLE_scaffold_034604_01G000200.1; TraesCLE_scaffold_034604_01G000200.
DR Gramene; TraesCLE_scaffold_080576_01G000100.1; TraesCLE_scaffold_080576_01G000100.1; TraesCLE_scaffold_080576_01G000100.
DR Gramene; TraesCS2A02G493700.1; TraesCS2A02G493700.1; TraesCS2A02G493700.
DR Gramene; TraesCS2A03G1152000.1; TraesCS2A03G1152000.1.CDS; TraesCS2A03G1152000.
DR Gramene; TraesCS2D02G493600.1; TraesCS2D02G493600.1; TraesCS2D02G493600.
DR Gramene; TraesCS2D03G1101000.1; TraesCS2D03G1101000.1.CDS; TraesCS2D03G1101000.
DR Gramene; TraesKAR2A01G0460060.1; cds.TraesKAR2A01G0460060.1; TraesKAR2A01G0460060.
DR Gramene; TraesKAR2B01G0477940.1; cds.TraesKAR2B01G0477940.1; TraesKAR2B01G0477940.
DR Gramene; TraesKAR2D01G0429410.1; cds.TraesKAR2D01G0429410.1; TraesKAR2D01G0429410.
DR Gramene; TraesPAR_scaffold_018940_01G000100.1; TraesPAR_scaffold_018940_01G000100.1; TraesPAR_scaffold_018940_01G000100.
DR Gramene; TraesPAR_scaffold_030712_01G000200.1; TraesPAR_scaffold_030712_01G000200.1; TraesPAR_scaffold_030712_01G000200.
DR Gramene; TraesPAR_scaffold_085115_01G000100.1; TraesPAR_scaffold_085115_01G000100.1; TraesPAR_scaffold_085115_01G000100.
DR Gramene; TraesROB_scaffold_023072_01G000100.1; TraesROB_scaffold_023072_01G000100.1; TraesROB_scaffold_023072_01G000100.
DR Gramene; TraesROB_scaffold_036448_01G000200.1; TraesROB_scaffold_036448_01G000200.1; TraesROB_scaffold_036448_01G000200.
DR Gramene; TraesROB_scaffold_086120_01G000200.1; TraesROB_scaffold_086120_01G000200.1; TraesROB_scaffold_086120_01G000200.
DR Gramene; TraesWEE_scaffold_000416_01G000100.1; TraesWEE_scaffold_000416_01G000100.1; TraesWEE_scaffold_000416_01G000100.
DR Gramene; TraesWEE_scaffold_017113_01G000300.1; TraesWEE_scaffold_017113_01G000300.1; TraesWEE_scaffold_017113_01G000300.
DR Gramene; TraesWEE_scaffold_093303_01G000200.1; TraesWEE_scaffold_093303_01G000200.1; TraesWEE_scaffold_093303_01G000200.
DR OMA; QACAISC; -.
DR OrthoDB; 5358603at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000019116; Chromosome 2A.
DR Proteomes; UP000019116; Chromosome 2D.
DR Proteomes; UP000280104; Chromosome ii.
DR Proteomes; UP000815260; Chromosome 2A.
DR Proteomes; UP000815260; Chromosome 2D.
DR ExpressionAtlas; A0A1D5UPW5; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IBA:GO_Central.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR GO; GO:0070905; F:serine binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0046655; P:folic acid metabolic process; IBA:GO_Central.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IBA:GO_Central.
DR GO; GO:0006565; P:L-serine catabolic process; IBA:GO_Central.
DR GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR GO; GO:0046653; P:tetrahydrofolate metabolic process; IBA:GO_Central.
DR CDD; cd00378; SHMT; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR HAMAP; MF_00051; SHMT; 1.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
DR InterPro; IPR039429; SHMT-like_dom.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF35; SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC; 1.
DR Pfam; PF00464; SHMT; 1.
DR PIRSF; PIRSF000412; SHMT; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00096; SHMT; 1.
PE 3: Inferred from homology;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563,
KW ECO:0000256|RuleBase:RU000585};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR000412-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000585}.
FT DOMAIN 12..411
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
FT MOD_RES 244
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR000412-50"
SQ SEQUENCE 471 AA; 51457 MW; 96ECB1B9746B45DF CRC64;
MDSVASWGLT PLADADPDVF DLIEREKRRQ RSGIELIASE NFTSFAVIEA LGSALTNKYS
EGMPGARYYG GNDVIDEIEN LCRDRALAAF RLDAASWGVN VQPYSGSPAN FAAYTALLNP
HDRIMGLDLP SGGHLTHGYY TAGGKKISAT SIYFESLPYK VSAANGYIDY DKLEEKAMDF
RPKLIICGGS AYPRDWDYAR LRAVADKVGA MLLCDMAHIS GLVAAQEAAN PFEFCDVVTT
TTHKSLRGPR AGMIFYRKGP KPAKKGQPEG AVYDYEDKIN FAVFPSLQGG PHNHQIAALA
VALKQTLTPG FKAYAKQVKA NAVAVGKYLM SKGYKMVTDG TDNHLVLWDL RPLGLTGNKV
EKMCDLCSIT LNKNAVFGDS SALSPGGVRI GAPAMTSRGL VEKDFEQIAE FLHQAVTICL
NIQKEHGKLL KDFSKGLVNN KDIENLKVEV EKFALSFDMP GFSLESMKYK E
//
