ID A0A1D6ER72_MAIZE Unreviewed; 1723 AA.
AC A0A1D6ER72;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=ZEAMMB73_Zm00001d005840 {ECO:0000313|EMBL:ONM22236.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:ONM22236.1};
RN [1] {ECO:0000313|EMBL:ONM22236.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Seedling {ECO:0000313|EMBL:ONM22236.1};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
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DR EMBL; CM007648; ONM22236.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D6ER72; -.
DR InParanoid; A0A1D6ER72; -.
DR ExpressionAtlas; A0A1D6ER72; baseline.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR PANTHER; PTHR45786; DNA BINDING PROTEIN-LIKE; 1.
DR PANTHER; PTHR45786:SF74; HELITRON_LIKE_N DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044}.
FT DOMAIN 650..824
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
FT DOMAIN 1545..1591
FT /note="DNA helicase Pif1-like 2B"
FT /evidence="ECO:0000259|Pfam:PF21530"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..351
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1723 AA; 197457 MW; 500371883C02D107 CRC64;
MDQIGYNAGR TPFTDISNTI ITGNQNESNS LGPIVDAKER KRQRDRERYA AMTVEEKNEK
NRKRREARQR NKGLSIEPLS SRAFCKWVTY EEDVNTDQAC ELVSFPEDCS TIDFTNLSTQ
DIAGGDKQVN LDAYDDSDWL HRNETFQANN IITSKDLLTP GCVHETVDNI PKHTMKRAAY
FSERYKNMTP VERESRRVRH RLYNKTPRRK DANKECSRKR RALQGDTLNQ ESIAMEDPLY
TPEVVIPEFI MTSFLPTSTQ TKDVGSLDMS TEPLRRRHHV LSETRPLGRR NQQFEAGIAR
NVATVTEDTI CDAMEEDDWT QPHPNAELHN NGDDDEGVIF EEDEDDDEND GYLFVGQYDE
IDEDIEIDGT QDESTATDLP DPYDKVYSNV PEETHMLKSV PNCGYCTAKK FEYEPPGFCC
RGGKVELAPL ETPPQLRRLW DSTDSDARHF RDNIRFFNGH FSFTSLYCCL DSMTTNVRDS
GIYTFRAQGM MYHNIKSFGR EGGAEHKHLE LYFYDDDPNL EHRFRKCREE CQQKDKDVIK
QLVGILRENP YSEHLRSMGH VENHDDYCIT LNLDQTLNQK TYNTPLTSEV AAVWIEGSER
RGQFSKSVML HGKDRSSHDI RSYHGCYDAL SYPLFFPRGE LGWHTNIPKI RPGIFNPILH
GKRLFQQFAV DTYIKIESSR LDFIRKNQDR LRADLYQGLV DSMLDGDIRA EKVGKRTVLS
PSFIGGPRDM RRRYMDAMAL VRKFGKPDIF LTMTCNPNWD EIRTELLPGQ TPQDRSDLVV
RVFHAKLQEL KHRLTKHDIL GKVRAYVYVV EFQKRGLPHA HFLLIMQRKY KLTCPEQYDL
LISAEIPDKK YPELRKMVIK HMMHGPCGSL NPICPCTKGR ASCKNHYPRP FCDATLQGKD
SYPIYRRRDD GRKEKVRGFE LDNRWVVPYN PYLLRLFNCH INVEACGSIK AVKYMFKYIY
KGHDRASVVM RDASKADDDV DEIKQYRDAR WVTPPEALWR IYDFELSQNS PPVMQLQLHL
PNMHMVAFHE RQMVERVVNR PGADRSMLTA YFEANMLHEE AQGILYRDFP EWYTWQSGKG
KVWQRRKRDT GEQVGRIISA HPAEGERYYL RVLLNHVTGA TSYVDLRTID GVTLPTFCEA
AERRGLLESD NTLDDCLTER ALFQMPSAPR RLFATILVYC EPSDVAVLWQ KHLDAMSEDY
QHRSQSKTHV EQMVLIDIRN MLQSMGKDIN TFPLPPIIDT YDDAIGTARE VYEEESIEAA
VGDVALKDSL NEEQRAAYDK ILSAVDTNQH GLFFVDGPVA TATSGVAASI MPGGRTAHSR
FKIPLTIDDG GVCSFTKQSG TAELLRKASL IIWDEASMTK KQVVEALDNS MRDIMGRPEL
PFGGKTIVFG GDFRQVLPVV RKGSRAQVVA SSLRMSYLWE SMSHLKLVSN MRAKNDPWFA
EYLLRVGGGT EVTNSDGDIR LPDEVCVPYS GSDNDLDNLI DFVFPNLNEN MSDSTYITSR
AILSTRNDWV DMINAKMIDR FQGEHMVYHS FDSAMDDPHN YYPPEFLNTL TPNGLPPHVL
KLKIGCPVIL LRNIDPANGL CNGTRLVVRG FQRNSIDAEI VLGQYAGKRI FLPRIPLCPS
DDEMFPFQFK RKQFPIRLSF AMTVNKAQGQ TIPNVGVYLP EPVFSHGQLY VALSRATARS
NIMILAIPAV GGKKRSRKGV RKNPTVDCGT YTKNIVYKEV LTN
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