ID A0A1D6EUN3_MAIZE Unreviewed; 1520 AA.
AC A0A1D6EUN3;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=MUTL protein homolog 3 {ECO:0000313|EMBL:ONM23364.1};
GN ORFNames=ZEAMMB73_Zm00001d006307 {ECO:0000313|EMBL:ONM23364.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:ONM23364.1};
RN [1] {ECO:0000313|EMBL:ONM23364.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Seedling {ECO:0000313|EMBL:ONM23364.1};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CM007648; ONM23364.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D6EUN3; -.
DR SMR; A0A1D6EUN3; -.
DR STRING; 4577.A0A1D6EUN3; -.
DR InParanoid; A0A1D6EUN3; -.
DR ExpressionAtlas; A0A1D6EUN3; baseline and differential.
DR GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:EnsemblPlants.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR GO; GO:0009555; P:pollen development; IEA:EnsemblPlants.
DR GO; GO:0048316; P:seed development; IEA:EnsemblPlants.
DR CDD; cd12534; RRM_SARFH; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 2.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF08676; MutL_C; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00641; zf-RanBP; 2.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00547; ZnF_RBZ; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 2.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 2.
DR PROSITE; PS50199; ZF_RANBP2_2; 2.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT REGION 149..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..383
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1520 AA; 169460 MW; 214523A7CE998AD4 CRC64;
MGWDGSAGST QDAGIAGAPS LELGLASRWS GREGTGGPQN GSVYVCNLPP GTDENMLAEY
FGTIGLLKKD KRNGRPKIWI YRDKVSNEPK GDATVTYEDP HAASAAVEWF NNKDFHGSTI
QVHIAESKSK DAFDNPTNLN TIAGVSEQDE VDNGAGRGRG RGDGPGKAWQ QDGDWMCPNT
SCGNVNFAFR GVCNRCGAAR PAGAGGTGGG GGGRGRGRGN SDARGSSRAG AGAATGGGPP
GLFGPNDWPC PMCGNINWAK RTKCNICNTS KPGTNEGGVR QVCIAIFLHF RGGRGGGYKE
LDEEELEEVK KRRKEAEEDD GEIYDEFGNL KKKFRSKALH TGSAQTLPGS GRAGWEVEHR
GSSEREGRER SRDRGRDDYD EKETRSIDRA RFEEMQTIKR LPKSVHSSLR SGVILSDLPR
VIEELIYNSI DANASKIDIA VNIRACYVKV EDDGCGITRD ELVLLGEKYT TSKFHVMVDE
ELSFRSFGLN GEALASLSDI SVVEGSKCLH LGIDDKREVV GTTGECSIFS LKQSSAWLVI
GPFNFAVVVR ELFYNQPVRR KQMQSSEKRE LHHVKKCVLQ IALIHPQISL RLLDNDSEDE
LLYTEISSSP LPLISKTFGD DISRCLHEIT ASDQVWTLSG HISGPADVFC TKDAQYLYIN
SRFVNRNPIH NMLNNLASSF RSPITRGYAE IDVQSRKRQK ADIYPAFILN FYCPRSTYDL
HFEPTKTIVE FKDWRTVLLF FEQSVTNYWK KHQLQSPKVK LNKGLLKDHN VQNEKEYAHF
ESTQQTNAVK DTNSDMSSTR ATRNSHCFSF VMEPSIQNVC FSGRITNSCR PDDNVASIDY
KLGYKQMHYP ENGSYKWLDD GPSHLNDDIS SVNPTCWKRQ RTEGIFHEYA YSGNLVMLED
VPTEGYFAHE QETELIGPEV EIPESCFRAL NKPNGMTPDF VQNKTNLKAQ TSGWDGLYDK
FEKLNGDCLL DNGFYHDGGS TSKGTCRVLR KSSTSKKLGT AAGCVEGLEA DAINQMNFPD
IHALWNSDLI DRSSFKDTLN HFSHPSLLAD TPCSHPRTLH TLNRTSDKCF RSWNYENIDS
NVRFSNDSSI IFEGTKNFDN FNNEIQSLNY FNDKCGSTDQ LGFEEDLTTW KSKFDMRLSV
NISPETAGDN GCHLNVPSLN IANDNLFTQD LLNQHNSGLN QRLRTSKCSR FRSHSAPPFY
RGKLKFSRLN VPLSKPSTDS DKDICVNNPE DNAPGPVDIP CISSTQPIPE TDSSEFPDLN
FSSLIPECVD KNCFEEARVL LQLDKKFIPV ISGETILLVD QHAADERIRL EELRSKVLSE
GHGVSYLDSE EELSLPETGF QLFQKYAEQI QKWGWIISGG SNSSESFKKN MNILKRQVRL
VTLVAVPCIF GVKLTGKDLM EFIWQLDETD GSSDMPPAVL RILNFKACRG AIMFGDPLLP
SECCLIIEEL KATSLCFQCA HGRPTTVPIL NIASLHDELA RLQMLSGRKA ETWHGLGHHE
PSLERAHMRL ERLRKLRRGL
//
