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Database: UniProt
Entry: A0A1D6FAD3_MAIZE
LinkDB: A0A1D6FAD3_MAIZE
Original site: A0A1D6FAD3_MAIZE 
ID   A0A1D6FAD3_MAIZE        Unreviewed;       653 AA.
AC   A0A1D6FAD3;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   18-SEP-2019, entry version 20.
DE   SubName: Full=Urease {ECO:0000313|EMBL:ONM28032.1};
GN   Name=100277946 {ECO:0000313|EnsemblPlants:Zm00001d007945_P009};
GN   ORFNames=ZEAMMB73_Zm00001d007945 {ECO:0000313|EMBL:ONM28032.1};
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae;
OC   PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae;
OC   Zea.
OX   NCBI_TaxID=4577 {ECO:0000313|EMBL:ONM28032.1};
RN   [1] {ECO:0000313|EMBL:ONM28032.1, ECO:0000313|EnsemblPlants:Zm00001d007945_P009, ECO:0000313|Proteomes:UP000007305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001d007945_P009,
RC   ECO:0000313|Proteomes:UP000007305};
RC   TISSUE=Seedling {ECO:0000313|EMBL:ONM28032.1};
RG   Maize Genome Sequencing Project;
RA   Ware D.;
RT   "Update maize B73 reference genome by single molecule sequencing
RT   technologies.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblPlants:Zm00001d007945_P009}
RP   IDENTIFICATION.
RC   STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001d007945_P009};
RG   EnsemblPlants;
RL   Submitted (MAY-2017) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|PIRSR:PIRSR611612-51};
CC       Note=Binds 2 nickel ions per subunit.
CC       {ECO:0000256|PIRSR:PIRSR611612-51};
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR611612-50}.
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DR   EMBL; CM007648; ONM28032.1; -; Genomic_DNA.
DR   EnsemblPlants; Zm00001d007945_T009; Zm00001d007945_P009; Zm00001d007945.
DR   Gramene; Zm00001d007945_T009; Zm00001d007945_P009; Zm00001d007945.
DR   OrthoDB; 183108at2759; -.
DR   Proteomes; UP000007305; Chromosome 2.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:InterPro.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   CDD; cd00375; Urease_alpha; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01953; Urease_alpha; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017950; Urease_AS.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   Pfam; PF00699; Urease_beta; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF51338; SSF51338; 2.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01792; urease_alph; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
DR   PROSITE; PS00145; UREASE_2; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007305};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00700};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR611612-51};
KW   Nickel {ECO:0000256|PIRSR:PIRSR611612-51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007305}.
FT   DOMAIN      210    653       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   ACT_SITE    401    401       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   METAL       215    215       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       217    217       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       298    298       Nickel 1; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       298    298       Nickel 2; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       327    327       Nickel 2; via pros nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       353    353       Nickel 2; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       441    441       Nickel 1. {ECO:0000256|PIRSR:PIRSR611612-
FT                                51}.
FT   BINDING     300    300       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     298    298       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR611612-50}.
SQ   SEQUENCE   653 AA;  69041 MW;  28329BAD2DBC8481 CRC64;
     MRLNILAGTA VRFEPGDAKS VILVSIGGHK VIKGGNGIAD GPIDSSSLNV VMQKVNANSF
     GHEDYPDARE GIIGDGSFDC TVDHEKYASI YGPTTGDKIR LGDTNLYAEI EKDFAFYGDE
     CIFGGGKVLR DGMGQASGYP ESFCLDTVIT NAVVIDYTGI YKADIGIKGG LIVAIGKAGN
     PDVMDGVHNN MIVGVNTEVI ASEGMIVTAG GIDCHVHFIC PQLAEEAIAS GITTLVGGGT
     GPAHGTCATT CTPAPSQLKL MLQSTDQLPI NMGFTGKGNT SKPEGLAEII KAGAMGLKLH
     EDWGTTPSAI DNCLSVAEDF DIQVNIHTDT LNESGCVEHT IAAFKGRAIH TYHSEGAGGG
     HAPDIIKVCG VKNVLPSSTN PTRPFTSNTV DEHLDMLMVC HHLDKNIPED VAFAESRIRA
     ETIAAEDILH DMGAISIISS DSQAMGRVGE VITRTWQTAN KMKVQRGSLP GSGDANAAPD
     SDNLRIRRYI AKYTINPAIV NGFSDFVGSV EVGKLADLVL WKPSFFGAKP ELVVKGGAIA
     WANMGDPNAS IPTPEPVVMR PMFGAFGKAG SSNSIAFVSK AAKEAGVATE YRLEKRVEAV
     GRVRGLTKLD MKLNDALPKI EVDPETYTVT ADGEVLTCQP APTLPLSRNY FLF
//
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