ID   A0A1D6GES2_MAIZE        Unreviewed;       913 AA.
AC   A0A1D6GES2;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=ZEAMMB73_Zm00001d013006 {ECO:0000313|EMBL:AQK62081.1};
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577 {ECO:0000313|EMBL:AQK62081.1};
RN   [1] {ECO:0000313|EMBL:AQK62081.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Seedling {ECO:0000313|EMBL:AQK62081.1};
RG   Maize Genome Sequencing Project;
RA   Ware D.;
RT   "Update maize B73 reference genome by single molecule sequencing
RT   technologies.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
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DR   EMBL; CM000781; AQK62081.1; -; Genomic_DNA.
DR   EMBL; CM000781; AQK62092.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1D6GES2; -.
DR   ExpressionAtlas; A0A1D6GES2; baseline and differential.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 2.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   NCBIfam; TIGR01063; gyrA; 1.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          101..537
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          49..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          490..529
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   913 AA;  100004 MW;  0A22B94C271EBF24 CRC64;
     MALSAALRLP LPLPRLLGPS AVIFGAASRR RAAAAAANAA ALRLLSASSP SPASFSSRPT
     RPLRSRRRNR GDDGRAAAAG GAGGGEGGGA GLVVKERILP VELHKEATEA YMSYAMSVLL
     GRALPDVRDG LKPVHRRILY AMHEMGLASR RPFRKCARVV GEVLGKFHPH GDTAVYESLV
     RMAQDFSMRY PLVQGHGNFG SVDADPPAAM RYTECRLDSL AEAMFLTDLE LNTVDFVPNF
     DNSQKEPSLL PSRVPSLLLN GSSGIAVGMA TNIPPHNLGE LVDVLSVIIE NREATLQELL
     ERMPGPDFPT GGTILGNQGI LEAYKSGRGR IVVRGKTDIE TIDEKSKRTA IIIKEIPYQT
     NKATLVQKIA ELVEDKVLEG ISDIRDESDR TGMRVVIELK RSADPAVVLN NLYRHTALQS
     SFSCNMVAIL DGQPKLMGLK EILQAFLDFR CSVIERRARY KLSQALERKH IVEICSKCLT
     CSCAEFDLSE KQAEALLDIT LKKLTSLERK KFVDEAKTMS EEISKLNELL SSKKLIFQLI
     QQEAADLKSK FSTPRRSVID DSISSEVDDI DIIPNEEMLL KILSEKGYAK RMNPDTFSLQ
     HRGTIGKSVG KMRMNDSTSD FIVCQTHDHV LYFSDKGIVY SARAYKIPEC TRTATGTPLV
     QLLPLSDGER ITSIIPVSEF GENQYLVMLT VNGYIKKVPL NAFSSIRSTG IISIQLVPGD
     ELKWVRHCGN DDLVALASQK GRVIVNSCDK LRALGRNTRG VCAMKLKEGD MMAAMDIIPA
     TVHKMPERCN SRLRDSSPPW LLFIAESGIG KRVPLNAFRQ SNFNAVGLQG YKLPADCRLA
     AVFVAGLSLT EDGESDEQVV LVSQSGTVNR IKVKDISIQS RRSRGVILMR LEHAGKIQSA
     SLISAAAAEV TED
//