ID   A0A1D6IH74_MAIZE        Unreviewed;       996 AA.
AC   A0A1D6IH74;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Insulin-degrading enzyme-like 1 peroxisomal {ECO:0000313|EMBL:ONM58852.1};
GN   ORFNames=ZEAMMB73_Zm00001d021846 {ECO:0000313|EMBL:ONM58852.1};
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577 {ECO:0000313|EMBL:ONM58852.1};
RN   [1] {ECO:0000313|EMBL:ONM58852.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Seedling {ECO:0000313|EMBL:ONM58852.1};
RG   Maize Genome Sequencing Project;
RA   Ware D.;
RT   "Update maize B73 reference genome by single molecule sequencing
RT   technologies.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; CM007650; ONM58852.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1D6IH74; -.
DR   SMR; A0A1D6IH74; -.
DR   IntAct; A0A1D6IH74; 2.
DR   STRING; 4577.A0A1D6IH74; -.
DR   InParanoid; A0A1D6IH74; -.
DR   ExpressionAtlas; A0A1D6IH74; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR   GO; GO:0043171; P:peptide catabolic process; IBA:GO_Central.
DR   GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          57..190
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          222..401
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          407..685
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          699..876
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   996 AA;  113505 MW;  20FBFA29C97ADF75 CRC64;
     MDSRPRETDA PGDPANGAAP PLAAAVTAAT GDVEIIRPRN DKRGYRRVVL PNSLECLLIS
     DPDTDKAAAS MNVSVGYFCD PDGLEGLAHF LEHMLFYASE KYPEEDSYSK YIAEHGGSTN
     AFTSSEHTNF YFDVNSDSLH DALDRFAQFF IKPLMSPDAT LREIKAVDSE NQKNLLSDPW
     RMSQLQKHLC AENHPYHKFS TGIHTGNWNT LEVKAKEKGL DTRLELIKFY DSHYSANLMQ
     LVVYGKDSLD NLQNLVENKF CDIRDVGRKP FSFPGHPCTP EHLQVLVKAV PIKQGHTLRI
     LFPITPNIRC YKEGPCKYIS HLIGHEGEGS LFYVLKKLGW AMSLEAGEGD WSHDFSFFCV
     VIQLTDVGQE HMEDTLGLLF RYIKLLQNSG TPKWIFDELQ AICETGFHYR DKSPPINYVV
     NISSNMQIFP PKDWLIASSV PSKFSPDAIQ NVLNELTPET VRIFWESKKF EGKTKLAEPW
     YGTSYSVEVV PPSIIQKWVG KAPEEDLHLP KRNIFIPSDL SLRSVEEKVS FPAMLRKTQF
     SRLWYKPDTM FFTPKAYIKM DFHCPLSQSS PESAVLTDVF TRLLMDYLND YAYDAQVAGL
     YYVVKPNDTG FQVTMVGFND KMRTLLETVI GKIAEFEVKA DRFSVIKEAM TKEYENFKFR
     QPYQQVLYYC SLILEDQTWP WDEEFSALSH LEASDLGIFL PHLLSKTFIE CYFAGNIEPN
     EANNIVQHVE DVLFNAPISA CKPLSPSQHL AKRIVKLEKG LRYYYPAMCS NHQDENSALL
     HYIQTHQDNV KQNVLLQLLA LVGKQPAFHQ LRSVEQLGYI ALLRQRNDSG VRGLQFIIQS
     TVKDPANLDA RVENFLNMFE SNVYNMSDAE FKSNVSALID MKLEKYKNIR EESAFFYGEI
     SEGTLKFDRK EAEVAALREL KKEELVGFFN DHVKVNAPQK KILSIQVYGG LHSAEYETIV
     QNAPPPPSCE ITDIYGFRRS RPLYGSFRGG VGQMKL
//