ID   A0A1D6J5Q3_MAIZE        Unreviewed;       904 AA.
AC   A0A1D6J5Q3;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=2-oxoglutarate dehydrogenase E1 component {ECO:0000313|EMBL:AQK43259.1};
GN   ORFNames=ZEAMMB73_Zm00001d025240 {ECO:0000313|EMBL:AQK43259.1};
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577 {ECO:0000313|EMBL:AQK43259.1};
RN   [1] {ECO:0000313|EMBL:AQK43259.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Seedling {ECO:0000313|EMBL:AQK43259.1};
RG   Maize Genome Sequencing Project;
RA   Ware D.;
RT   "Update maize B73 reference genome by single molecule sequencing
RT   technologies.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00006936}.
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DR   EMBL; CM000786; AQK43259.1; -; Genomic_DNA.
DR   EMBL; CM000786; AQK43273.1; -; Genomic_DNA.
DR   EMBL; CM000786; AQK43274.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1D6J5Q3; -.
DR   OMA; HERINRW; -.
DR   ExpressionAtlas; A0A1D6J5Q3; baseline and differential.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          519..732
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   904 AA;  103196 MW;  4BB05736C383535F CRC64;
     MRLLLLVRAY QVSGHLKAKL DPLGLEERPV PDVLDPAFYG FSEADLDREF FLGVWMMAGF
     LSENRPVQTL RSVLERLEQA YCGTIGYEYM HIPDREKCNW LRDRIETVNP MDYTYDRRQV
     MLDRLIWSTQ FESFLATKWT TAKRFGLEGA ETLIPGMKEM FDRAAHLGVE SIVIGMPHRG
     RLNVLGNVVR KPLRQIFSEF SGGTKPVNEG EGLYTGTGDV KYHLGTSYDR PTRGGKHIHL
     SLVANPSHLE AVDPVVAGKT RAKQYYSNDR DRTKNLGVLL HGDGSFSGQG VVYETLHLSA
     LENYTTGGTI HIVVNNQVAF TTDPRSGRSS QYCTDVAKAL DAPIFHVNGD DLEAVVHVCE
     LAAEWRQTFH SDVVVDIVCY RRFGHNEIDE PSFTQPKMYK VIRNHPSALE IYQRKLLESG
     KISKEDIDRL NKKVSTILNE EFQNSKDYVP NKRDWLSAYW TGFKSPEQIS RIRNTGVKPE
     ILKRVGEAMT TLPENFKPHR AVKKIFDLRR QMIETGEGID WAVGEALAFA TLIIEGNHVR
     LSGQDVERGT FSHRHSVIHD QETGEQYCPL DHLVMNQDAE LFTVSNSSLS EFAVLGFELG
     YSMENPNSLV LWEAQFGDFS NGAQVIFDQF LSSGESKWLR QTGLVVCLPH GYDGQGPEHS
     SARLERFLQM SDDNPYVIPE MDPTLRKQIQ QCNWQVVNVT TPANYFHVLR RQIHRDFRKP
     LIVMSPKNLL RHKDCKSNLS EFDDLAGHPG FDKQGTRFKR LIKDQNNHKD LEEGINRLVL
     CSGKVYYELD EERRKSERTD VAICRVEQLC PFPYDLIQRE LKRYPNAEIV WCQEEPMNMG
     AYSYINPRLL TAMKVLGRGG IEDIKYVGRA PSAATATGFY SVHVQEQTEL VQKALQRDPL
     NYPF
//