ID A0A1D6KXJ0_MAIZE Unreviewed; 495 AA.
AC A0A1D6KXJ0;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN Name=100275607 {ECO:0000313|EnsemblPlants:Zm00001eb051160_P001};
GN ORFNames=ZEAMMB73_Zm00001d033296 {ECO:0000313|EMBL:ONM07172.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:ONM07172.1};
RN [1] {ECO:0000313|EMBL:ONM07172.1, ECO:0000313|Proteomes:UP000007305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb051160_P001,
RC ECO:0000313|Proteomes:UP000007305};
RC TISSUE=Seedling {ECO:0000313|EMBL:ONM07172.1};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:Zm00001eb051160_P001}
RP IDENTIFICATION.
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb051160_P001};
RG EnsemblPlants;
RL Submitted (MAY-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
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DR EMBL; CM007647; ONM07172.1; -; Genomic_DNA.
DR RefSeq; NP_001143129.2; NM_001149657.2.
DR AlphaFoldDB; A0A1D6KXJ0; -.
DR SMR; A0A1D6KXJ0; -.
DR IntAct; A0A1D6KXJ0; 1.
DR STRING; 4577.A0A1D6KXJ0; -.
DR PaxDb; 4577-GRMZM2G021055_P01; -.
DR EnsemblPlants; Zm00001eb051160_T001; Zm00001eb051160_P001; Zm00001eb051160.
DR GeneID; 100275607; -.
DR Gramene; Zm00001eb051160_T001; Zm00001eb051160_P001; Zm00001eb051160.
DR KEGG; zma:100275607; -.
DR eggNOG; KOG1347; Eukaryota.
DR InParanoid; A0A1D6KXJ0; -.
DR OMA; ISFRTKW; -.
DR OrthoDB; 10858at2759; -.
DR Proteomes; UP000007305; Chromosome 1.
DR ExpressionAtlas; A0A1D6KXJ0; baseline and differential.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR11206:SF509; PROTEIN DETOXIFICATION; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Reference proteome {ECO:0000313|Proteomes:UP000007305};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 26..53
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 73..96
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 173..195
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 201..225
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 246..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 291..312
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 324..347
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 367..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 397..419
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 425..448
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT REGION 468..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 52790 MW; 495213F8D6277DDC CRC64;
MPSSSSMGMG MGKAAVVSKS WQESKLLWHI AFPAILTAVF QFSIGFVTVG FVGHIGSVEL
AAVTVVENVI EGFAYGVLLG MGSALETLCG QAVGAGQVGM LGVYIQRSWI ICGATAVLLT
PTYLFTAPIL RALRQPADVA RVAGAYCRWV LPQLFAYAAN FPLQKFFQAQ SRVWVVTAIS
GAALALHVAL NYVFVARMGH GLPAAAAVGN VTWWLVIAAQ VAYLLSGRFE DAWRGFSRLA
FANLAAFVKL SLASAVMLCL ELWYYTAVLI LVGFLKNARL QIDVMSICIN YQLWTLMVAL
GFNAAVSVRV SNELGANRPK AAKFAVTVAV LTSGSVGAVF LAVFLAWRTG LPRFFSEDGD
VLREASRLGY LLAGSIFLNS VQPVLSGVAI GAGWQALVAV VNIGSYYFVG IPLAALFGFK
LGMDAMGIWL GMTLGTLLQT AILVFISYRT KWEKQAMRAE ERVREWGGRA DALPSATQVA
PAAEDAGPPS NASAT
//
