ID A0A1D6L981_MAIZE Unreviewed; 515 AA.
AC A0A1D6L981;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 13-SEP-2023, entry version 39.
DE RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
GN ORFNames=ZEAMMB73_Zm00001d034602 {ECO:0000313|EMBL:ONM10746.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:ONM10746.1};
RN [1] {ECO:0000313|EMBL:ONM10746.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Seedling {ECO:0000313|EMBL:ONM10746.1};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU003862};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU003862}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743, ECO:0000256|RuleBase:RU003862}.
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DR EMBL; CM007647; ONM10746.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D6L981; -.
DR UniPathway; UPA00193; -.
DR ExpressionAtlas; A0A1D6L981; baseline and differential.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003862};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003862};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003862}.
SQ SEQUENCE 515 AA; 57785 MW; A47786BDC943099E CRC64;
MMHLTCTNMP VEKIDHALET IKSNGIQNVL ALRGDPPHGQ DKFVQVEGGF ACALDLVQHI
RAKYGDYFGI TVAGYPEAHP DAIQGEGGAT LEAYSNDLAY LKRKVDAGAD LIVTQLFYDT
DIFLKFVNDC RQIGITCPIV PGIMPINNYK GFLRMTGFCK TKIPSEITAA LDPIKDNEEA
VRQYGIHLGT EMCKKILATG IKTLHLYTLN MDKSAIGILM NLGLIEESKV SRPLPWRPAT
NVFRVKEDVR PIFWANRPKS YLKRTLGWDQ YPHGRWGDSR NPSYGALTDH QFTRPRGRGK
KLQEEWAVPL KSVEDISERF TNFCQGKLTS SPWSELDGLQ PETKIIDDQL VNINQKGFLT
INSQPAVNGE KSDSPTVGWG GPGGYVYQKA YLEFFCAKEK LDQLIEKIKA FPSLTYIAVN
KDGETFSNIS PNAVNAVTWG VFPGKEIIQP TVVDHASFMV WKDEAFEIWT RGWGCMFPEG
DSSRELLEKV QKTYYLVSLV DNDYVQGDLF AAFKI
//
