ID A0A1D6LLS4_MAIZE Unreviewed; 1016 AA.
AC A0A1D6LLS4;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN ORFNames=ZEAMMB73_Zm00001d036328 {ECO:0000313|EMBL:AQK80631.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:AQK80631.1};
RN [1] {ECO:0000313|EnsemblPlants:Zm00001eb271700_P001, ECO:0000313|Proteomes:UP000007305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb271700_P001,
RC ECO:0000313|Proteomes:UP000007305};
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [2] {ECO:0000313|EMBL:AQK80631.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Seedling {ECO:0000313|EMBL:AQK80631.1};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:Zm00001eb271700_P001}
RP IDENTIFICATION.
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb271700_P001};
RG EnsemblPlants;
RL Submitted (MAY-2021) to UniProtKB.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00006936}.
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DR EMBL; CM000782; AQK80631.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D6LLS4; -.
DR SMR; A0A1D6LLS4; -.
DR IntAct; A0A1D6LLS4; 6.
DR STRING; 4577.A0A1D6LLS4; -.
DR PaxDb; 4577-GRMZM2G151169_P01; -.
DR EnsemblPlants; Zm00001eb271700_T001; Zm00001eb271700_P001; Zm00001eb271700.
DR Gramene; Zm00001eb271700_T001; Zm00001eb271700_P001; Zm00001eb271700.
DR eggNOG; KOG0450; Eukaryota.
DR InParanoid; A0A1D6LLS4; -.
DR OMA; SFCGQGV; -.
DR Proteomes; UP000007305; Chromosome 6.
DR ExpressionAtlas; A0A1D6LLS4; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0045252; C:oxoglutarate dehydrogenase complex; IBA:GO_Central.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IBA:GO_Central.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR CDD; cd02016; TPP_E1_OGDC_like; 1.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR InterPro; IPR032106; 2-oxogl_dehyd_N.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR031717; KGD_C.
DR InterPro; IPR042179; KGD_C_sf.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR23152:SF23; OXOGLUTARATE DEHYDROGENASE (SUCCINYL-TRANSFERRING); 1.
DR Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF16870; OxoGdeHyase_C; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 1: Evidence at protein level;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A1D6LLS4};
KW Reference proteome {ECO:0000313|Proteomes:UP000007305};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT DOMAIN 632..845
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 1016 AA; 114812 MW; A57BE428A1EAC77B CRC64;
MTWFRAASGA ARLALRRSLA TRTPPAAATR CGRCFHSTAM RPRSAAPVPR AVPLSRLSDS
FLDGTSSVYL EELQRTWEAD PSSVDESWDN FFRNFVAQAS PSAGVSGQTI QESMQLLLLV
RAYQVNGHMM AKLDPLGLDD RAVPEDLRLG LYGFTEADLD REFFLGVWRM SGFLSENRPV
LTLREILNKL QQAYCGPIGY EYMHIPDRDK CNWLREKIET AKPKEYNKDR RLVMLDRLIW
STQFENFLAT KWATAKRFGL EGGETLIPGM KEMFDRAADL GVENIVIGMP HRGRLNVLGN
VVRKPLSQIF SEFTGGTRPV EGEDGLYTGT GDVKYHLGTS YDRPTRGGNR IHLSLVANPS
HLEAVDPVVI GKTRAKQFYS NDADRTKNMG ILIHGDGSFA GQGVVYETLH LSALPNYTTG
GTIHIVVNNQ VAFTTDPRAG RSSQYCTDVA KALNAPIFHV NGDDLEAVVC VCELAAEWRQ
TFHSDVVVDL ICYRRFGHNE IDEPSFTQPK MYQVIKNHPS SLKLYEQKLL GTGEVMKEDV
QRIHDKVNRI LNEEFAKSKD YVPNKRDWLS AYWTGFKSPE QISRVRNTGV KPEILKRVGQ
AITTLPENFK PHRAVKKIFE LRAAMIESGQ GIDWAVAEAL AFATLIVEGN HVRLSGQDVE
RGTFSHRHAV LHDQETGAKY CPLDHVAMDQ NEELFTVSNS SLSEFAVLGF ELGYSMENPN
SLVLWEAQFG DFANGAQVMF DQFLSSGEAK WLRQTGLVVL LPHGYDGQGP EHSSARLERF
LQMSDDNPFV IPEMEPTLRK QIQECNWQVV NVTTPANYFH LLRRQIHREF RKPLIVTAPK
NLLRHKDCKS NLSEFDDVEG HLGFDKQGTR FKRLIKDRND HKQVEEGVNR LILCSGKVYY
ELDEERKKSE RGDVAICRVE QLCPFPYDLI QRELKRYPNA EIVWCQEEPM NMGAYSYISP
RLFTAMKALG RGSFEDIKYV GRAPSAATAT GFLSVHAQEQ SELVKKALQA EPIKFL
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