ID   A0A1D6N3D1_MAIZE        Unreviewed;       468 AA.
AC   A0A1D6N3D1;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   SubName: Full=Signal peptide peptidase-like 3 {ECO:0000313|EMBL:ONM35197.1};
GN   ORFNames=ZEAMMB73_Zm00001d042378 {ECO:0000313|EMBL:ONM35197.1};
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577 {ECO:0000313|EMBL:ONM35197.1};
RN   [1] {ECO:0000313|EMBL:ONM35197.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Seedling {ECO:0000313|EMBL:ONM35197.1};
RG   Maize Genome Sequencing Project;
RA   Ware D.;
RT   "Update maize B73 reference genome by single molecule sequencing
RT   technologies.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that
CC       cleaves type II membrane signal peptides in the hydrophobic plane of
CC       the membrane. {ECO:0000256|ARBA:ARBA00003012}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the peptidase A22B family.
CC       {ECO:0000256|ARBA:ARBA00006859}.
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DR   EMBL; CM007649; ONM35197.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1D6N3D1; -.
DR   ExpressionAtlas; A0A1D6N3D1; baseline and differential.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR   Gene3D; 3.50.30.30; -; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007369; Peptidase_A22B_SPP.
DR   InterPro; IPR006639; Preselin/SPP.
DR   PANTHER; PTHR12174; SIGNAL PEPTIDE PEPTIDASE; 1.
DR   PANTHER; PTHR12174:SF72; SIGNAL PEPTIDE PEPTIDASE-LIKE 3; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04258; Peptidase_A22B; 1.
DR   SMART; SM00730; PSN; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
PE   3: Inferred from homology;
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          88..168
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
SQ   SEQUENCE   468 AA;  50125 MW;  AACD36E37FED8C70 CRC64;
     MALRTFPPRV LLLSVVLLAA PAAGAGTGSE FDDGTSPKFP GCDNTLQKVK VTYWVDGDER
     SSLTGISARF GAVLPDAAPD DEKQRAAVPS PESGCAKSST PLAGSVAVAV RGECTFIEKA
     KAAEAGGAVA LLLVNDEDDL QRMVCSDKDS PPNIGIPVVM VSKSAGDKVQ SAIGDGSKVD
     ILMYAPLKPS FDGAIPFLWM MAVGTVACAS VWTVVVVGEE PTKQGDVSLG GEENPDAEVV
     ELQANTALVF IVTSSLVLLF LFFFNSNWSA WLLVCLFCLG SLQGMEFVVS SLVVRLCQRC
     REAKVKLPAL GNVKVVTLVV LPLAFIFAVT WAAHQDSPVA WVGQNLMGIC MMILVLQVVH
     MPNIKVASAL LVSAFFYDIF WVFISPLIFK KSVMITVARG SDDGPSLPMV LKMPKEFDSW
     NGYDMIGFGD ILFPGLLVAF SFRYDRTHGK DLTDGYFLCL MIGYAFGT
//