ID   A0A1D6PT08_MAIZE        Unreviewed;       768 AA.
AC   A0A1D6PT08;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   ORFNames=ZEAMMB73_Zm00001d049190 {ECO:0000313|EMBL:AQK49808.1};
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577 {ECO:0000313|EMBL:AQK49808.1};
RN   [1] {ECO:0000313|EMBL:AQK49808.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Seedling {ECO:0000313|EMBL:AQK49808.1};
RG   Maize Genome Sequencing Project;
RA   Ware D.;
RT   "Update maize B73 reference genome by single molecule sequencing
RT   technologies.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; CM000780; AQK49803.1; -; Genomic_DNA.
DR   EMBL; CM000780; AQK49808.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1D6PT08; -.
DR   ExpressionAtlas; A0A1D6PT08; baseline and differential.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblPlants.
DR   GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR   GO; GO:0000347; C:THO complex; IEA:EnsemblPlants.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:EnsemblPlants.
DR   GO; GO:0009793; P:embryo development ending in seed dormancy; IEA:EnsemblPlants.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IEA:EnsemblPlants.
DR   GO; GO:0010082; P:regulation of root meristem growth; IEA:EnsemblPlants.
DR   CDD; cd17753; MCM2; 1.
DR   Gene3D; 2.20.28.10; -; 1.
DR   Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR031327; MCM.
DR   InterPro; IPR008045; MCM2.
DR   InterPro; IPR018525; MCM_CS.
DR   InterPro; IPR001208; MCM_dom.
DR   InterPro; IPR041562; MCM_lid.
DR   InterPro; IPR027925; MCM_N.
DR   InterPro; IPR033762; MCM_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR   PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR   Pfam; PF00493; MCM; 1.
DR   Pfam; PF17855; MCM_lid; 1.
DR   Pfam; PF14551; MCM_N; 1.
DR   Pfam; PF17207; MCM_OB; 1.
DR   PRINTS; PR01657; MCMFAMILY.
DR   PRINTS; PR01658; MCMPROTEIN2.
DR   SMART; SM00350; MCM; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00847; MCM_1; 1.
DR   PROSITE; PS50051; MCM_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          331..537
FT                   /note="MCM"
FT                   /evidence="ECO:0000259|PROSITE:PS50051"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   768 AA;  87161 MW;  6F94A652399339D2 CRC64;
     MSSGGDVPMT DQTDDDPYED EFDEEDEMNM YRVQGTLREW VTRDEVRRFI AKKFKEFLLT
     YVHPKNDQGE FEYVRLINEM VLANKCSLEI DYKQFIYIHP NIAIWLADAP QSVLEVMEEV
     AKNVVFDLHK NYRNIHQKIY VRISNLPVYD QIRNIRQIHL NTMIRIGGVV TRRSGVFPQL
     QQVKYDCNKC GTILGPFFQN SYTEVKVGSC PECQSKGPFT VNVEQTIYRN YQKLTLQESP
     GIVPAGRLPR YKEVILLNDL IDCARPGEEI EVTGIYTNNF DLSLNTKNGF PVFATVVEAN
     YVAKKQDLFS AYKLTDEDKA EIEKLSKDPR IGERIIKSIA PSIYGHEDIK TAIALAMFGG
     QEKNVKGKHR LRGDINVLLL GDPGTAKSQF LKYVEKTGHR AVYTTGKGAS AVGLTAAVHK
     DPVTREWTLE GGALVLADRG ICLIDEFDKM NDQDRVSIHE AMEQQSISIS KAGIVTSLQA
     RCSVIAAANP VGGRYDSSKT FTQNVELTDP IISRFDVLCV VKDIVDPFTD EMLARFVVDS
     HARSQPKGAN LEDRVSTDVD DDPLAAARQA DPDVLSQDML KKYITYAKLN VFPKIHDADL
     DKISHVYAEL RRESSHGQGV PIAVRHIESI IRMSEAHARM HLRSYVSQED VDMAIRVLLD
     SFISTQKFGV QKALQKNFRK YMTFKKDYNE LLLLLLRTLV KDAVHFEEIM AGSASRLTHV
     EVKLEDLRNK AQEYEIYDLK PFFSSACFRD NGFLLDEGRG IIRHPLAE
//