ID A0A1D6UPQ5_CHICK Unreviewed; 898 AA.
AC A0A1D6UPQ5;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Glutamate metabotropic receptor 1 {ECO:0000313|Ensembl:ENSGALP00010007335.1};
DE SubName: Full=Glutamate receptor metabotropic 1 isoform f transcript variant 1 {ECO:0000313|EMBL:AFL55414.1};
GN Name=GRM1 {ECO:0000313|EMBL:AFL55414.1,
GN ECO:0000313|Ensembl:ENSGALP00010007335.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AFL55414.1};
RN [1] {ECO:0000313|EMBL:AFL55414.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Shek-ki {ECO:0000313|EMBL:AFL55414.1};
RA Chung K.M., Kwok A.H., Wang Y., Ho J.C., Leung F.C.;
RT "Molecular Cloning and Characterization of Chicken Glutamate Receptor,
RT Metabotropic 1 (GRM1).";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGALP00010007335.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010007335.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; JQ806336; AFL55414.1; -; mRNA.
DR RefSeq; XP_015139774.1; XM_015284288.1.
DR PaxDb; 9031-ENSGALP00000020068; -.
DR Ensembl; ENSGALT00010012771.1; ENSGALP00010007335.1; ENSGALG00010005371.1.
DR VEuPathDB; HostDB:geneid_421614; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01030000234595; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000012297; Expressed in cerebellum.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15449; 7tmC_mGluR1; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001256; GPCR_3_mGluR1.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF29; METABOTROPIC GLUTAMATE RECEPTOR 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01051; MTABOTROPC1R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AFL55414.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..898
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014267311"
FT TRANSMEM 586..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 804..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 584..846
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 870..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 898 AA; 100209 MW; 5792F78683770A1E CRC64;
MTAVLPLVLP ALLLAGAALP PAAASAQRSV ARMDGDVIIG ALFSVHHQPP AEKVPERKCG
EIREQYGIQR VEAMFHTLDK INADPVLLPN ITLGSEIRDS CWHSSVALEQ SIEFIRDSLI
SIRDDREGGG RCLSDSQPQP PGRLRKPIAG VIGPGSSSVA IQVQNLLQLF DIPQIAYSAT
SIDLSDKTLY KYFLRVVPSD TLQARAMLDI VKRYNWTYVS AVHTEGNYGE SGMEAFKELA
AQEGLCIAHS DKIYSNAGEK SFDRLLRKLR ERLPKARVVV CFCEGMTVRG ILIAMRRLGV
LGEFLLIGSD GWADRDEVIE GYEQEANGGI TIKLQSPEVL SFDDYYLKLR LDTNTRNPWF
PEFWQHRFQC RIPGHPLENP NFQKNCTGNE SLEENYVQDS KMGFVINAIY AMAHGLQNMH
HSLCPGHVGL CDAMKPIDGS KLLEFLLKST FIGVSGEEVW FDEKGDAPGR YDIMNLQYIE
PNRYDYVLIG TWHEGVLNID DYRIQMNKSG MVRSVCSEPC LKGQIKVIRK GEVSCCWICT
ACKENEFVQD EFTCKACELG WWPNAELTGC EPIPVKYLQW SNIESIVAVV FSCLGILVTM
FVTLIFVLYR DTPVVKSSSR ELCYIILAGI FLGYVCPFTL IAKPTTISCY LQRLLVGLSS
AMCYSALVTK TNRIARILAG SKKKICTRKP RFMSAWAQVV IASILISVQL TLVVTLIILE
PPMPILSYPS IKEVYLICNT SNLGVVAPVG YNGLLIMSCT YYAFKTRNVP ANFNEAKYIA
FTMYTTCIIW LAFVPIYFGS NYKIITTCFA VSLSVTVALG CMFTPKMYII IAKPERNVRS
AFTTSDVVRM HVGDGKAPCK SNTFLNIFRR KKPGAGNPKK RQPEFSPTSQ CPSAHVQL
//
