ID A0A1D6Y7I7_9VIRU Unreviewed; 446 AA.
AC A0A1D6Y7I7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Dihydrofolate reductase-thymidylate synthase {ECO:0000313|EMBL:ALX27628.1};
GN ORFNames=GMAR_ORF254 {ECO:0000313|EMBL:ALX27628.1};
OS Golden Marseillevirus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Marseilleviridae; Marseillevirus.
OX NCBI_TaxID=1720526 {ECO:0000313|EMBL:ALX27628.1, ECO:0000313|Proteomes:UP000203012};
RN [1] {ECO:0000313|EMBL:ALX27628.1, ECO:0000313|Proteomes:UP000203012}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Golden {ECO:0000313|EMBL:ALX27628.1,
RC ECO:0000313|Proteomes:UP000203012};
RX PubMed=27739526; DOI=10.1038/srep35237;
RA Dos Santos R.N., Campos F.S., Medeiros de Albuquerque N.R., Finoketti F.,
RA Correa R.A., Cano-Ortiz L., Assis F.L., Arantes T.S., Roehe P.M.,
RA Franco A.C.;
RT "A new marseillevirus isolated in Southern Brazil from Limnoperna
RT fortunei.";
RL Sci. Rep. 6:35237-35237(2016).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KT835053; ALX27628.1; -; Genomic_DNA.
DR RefSeq; YP_009310371.1; NC_031465.1.
DR GeneID; 29674559; -.
DR KEGG; vg:29674559; -.
DR OrthoDB; 13491at10239; -.
DR Proteomes; UP000203012; Genome.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:InterPro.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR CDD; cd00209; DHFR; 1.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548:SF2; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000203012};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 3..212
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 446 AA; 50765 MW; A91767A54439BE81 CRC64;
MTRYFMIFAC DEKGGIGNKG KIPWHLPEDL ALFQRMTFGR TVIYGRKTLE SFPGQKPLQK
RRNIVLSRNP NFSIEGAEVC SSLEEAFSRC GDYPIIIGGE TVYTEALTKY PELCLGVCQT
VVAGTHTCDT FFSVGESPFE YDIKGSEKFR TLMLHNFDCG EIGYLALLSR VMRFGQERKD
RTGTGTKSLF AKTLYFPDVS KEFPLVTTKK TNWGKILSEL LWFLSGCTDA RVLKQKGSDI
WDGNSSKEFQ KTRGLENYTE GDCGPIYPFQ WRHAGAEYKG CSEDYRGKGK DQIMEMVRLI
QEEPDSRRIL LQSWNVSDLD KMVLPPCHMT FQVDVRGDKL DGQVYQRSAD LALGVPFNIA
SYACLLMLLA KRTGKEASNL TLCFGNVHVY NNHMENAQKM IERCPRKPSV LEIKRIADPN
LFDLKEEDFE LRDYQSYGAL NFDMAV
//
