ID A0A1D7NLF4_9SPHN Unreviewed; 749 AA.
AC A0A1D7NLF4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=methylmalonyl-CoA mutase {ECO:0000256|ARBA:ARBA00012398};
DE EC=5.4.99.2 {ECO:0000256|ARBA:ARBA00012398};
GN ORFNames=BG023_111699 {ECO:0000313|EMBL:AOL94625.1};
OS Porphyrobacter sp. LM 6.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Erythrobacteraceae; Erythrobacter/Porphyrobacter group; Porphyrobacter.
OX NCBI_TaxID=1896196 {ECO:0000313|EMBL:AOL94625.1, ECO:0000313|Proteomes:UP000094080};
RN [1] {ECO:0000313|EMBL:AOL94625.1, ECO:0000313|Proteomes:UP000094080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LM 6 {ECO:0000313|EMBL:AOL94625.1,
RC ECO:0000313|Proteomes:UP000094080};
RA Hentchel K., Vargas G., Fiebig A., Coleman M., Crosson S.;
RT "Genome sequences of bacteria isolated from the littoral zone of southern
RT Lake Michigan.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC Evidence={ECO:0000256|ARBA:ARBA00001922};
CC -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
CC {ECO:0000256|ARBA:ARBA00008465}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP017113; AOL94625.1; -; Genomic_DNA.
DR RefSeq; WP_069310043.1; NZ_CP017113.1.
DR AlphaFoldDB; A0A1D7NLF4; -.
DR STRING; 1896196.BG023_111699; -.
DR KEGG; porl:BG023_111699; -.
DR PATRIC; fig|1896196.3.peg.1686; -.
DR OrthoDB; 9762378at2; -.
DR Proteomes; UP000094080; Chromosome.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IEA:InterPro.
DR CDD; cd02071; MM_CoA_mut_B12_BD; 1.
DR CDD; cd03679; MM_CoA_mutase_alpha_like; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR InterPro; IPR006159; Acid_CoA_mut_C.
DR InterPro; IPR016176; Cbl-dep_enz_cat.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR InterPro; IPR006098; MMCoA_mutase_a_cat.
DR NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR NCBIfam; TIGR00641; acid_CoA_mut_N; 1.
DR PANTHER; PTHR48101:SF4; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF01642; MM_CoA_mutase; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 608..740
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 749 AA; 80794 MW; 8D1F0A1AAF7ED552 CRC64;
MTNKPTLEDW NALAAKEVKG RDLTWHTPEG FDIKPLYTAE DHAGFDPGLP GFAPFTRGVK
ASMYAGRPWT IRQYAGFSTA EESNAFYRRN LAMGQKGLSV AFDLATHRGY DSDHPRVVGD
VGKAGVAIDT VADMEILFDQ IPLDSMSVSM TMNGAVIPVL AFFIVAAERQ GVSQDKLDGT
IQNDILKEFM VRNTYIYPPE PSMRIISDII AYTSANMPKF NSISISGYHM HEAGATAVQE
LAFTIADGKE YAQRAMAAGL DIDAFAGRLS FFFGIGMNFF MEIAKLRAAR TLWHRVMDGL
GAKDERSKML RTHCQTSGVS LQEQDPYNNV IRTTVEAMAA VLGGTQSLHT NALDEAIALP
TDFSARIARN TQLVLQEESG ITSVVDPLGG SHYIEALTKT LVDEAWKLIE EVDAAGGMTA
FVATGAPKAA IERAAAEKQT KVDKGETVIV GVNKYRKEQE DALETLEVDN QKVRAGQIAR
IEKVRAGRDE AKCRAALAAL TEAARANPMT HREAIVTGRD ERGIPLPPSK IAELEKLADV
NLLAKAIECA RADATLGEIS AAMEEVFGRH DATPAPVKGV YASAYEFDRR WAQVVDGVES
VGRRLGRKPR IMVAKMGQDG HDRGANVIAS AFNDMGFEVI SGPLFQTPSE ACAMALAHDV
DVVGASSLAA GHKTLIPELI RLLREAGRGD IKVTAGGVIP PQDYDFLREA GVQGIYGPGS
NVVECAADIL VLLGHNMPPL GAGLDEAAE
//
