ID A0A1D7VHH5_9ACTN Unreviewed; 1116 AA.
AC A0A1D7VHH5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Regulator {ECO:0000313|EMBL:AOP46177.1};
GN ORFNames=SL103_07940 {ECO:0000313|EMBL:AOP46177.1};
OS Streptomyces lydicus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=47763 {ECO:0000313|EMBL:AOP46177.1, ECO:0000313|Proteomes:UP000094094};
RN [1] {ECO:0000313|EMBL:AOP46177.1, ECO:0000313|Proteomes:UP000094094}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=103 {ECO:0000313|EMBL:AOP46177.1,
RC ECO:0000313|Proteomes:UP000094094};
RA Jia N., Ding M.-Z., Gao F., Yuan Y.-J.;
RT "Complete genome sequencing of Streptomyces lydicus 103 and metabolic
RT pathways analysis of antibiotic biosynthesis.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP017157; AOP46177.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D7VHH5; -.
DR KEGG; slc:SL103_07940; -.
DR OrthoDB; 499349at2; -.
DR Proteomes; UP000094094; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR049052; nSTAND1.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF20703; nSTAND1; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Reference proteome {ECO:0000313|Proteomes:UP000094094};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 1..90
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 1..90
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 240..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..259
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 119560 MW; 009C3588C66EDE68 CRC64;
MRYGILGTTQ AGRADGTPVA VGGARLRALL AAFALRPGRA LTPDVLIADV WGMDPPADAA
GALQALVGRL RRALGRDAIA SVDGGYRLCA EPDAVDLHRF ERLAADGERA LAEADPDRAA
AVLDEALGLW RGPALADLPE PGVEAARAES RRLDVQRTRL AADLALGRPD RALPTLLALC
RDHPLDEPLQ ALRLRALRAA GRGAEALAAY EEIRTDLADR LGADPGPELR ALHGELLRPQ
PAVAPAPPAP APAAAAPAPA AAPPGNLRAR LTSFVGRDAD LVALRSDLTE HRLVTLLGPG
GAGKTRLSQE GAESAVAAQP DAWPHGVWLA ELAPVDDPQT VPEAVLTALG ARETVVRGTT
SEGLRAATDP TALNPLGRLA EHCAGRRMLL VLDNCEHVID AAAQLVERLL ADCPGVTVLA
TSREPLAVPG EVLRPVEPLP DPVALRLLAD RGAAARPGFR VADDPAACTE ICRRLDGLPL
AVELAAARLR LLTPRQLADR LDDRFRLLTS GSRTLLPRQQ TLRAVVDWSW DLTDEPERAV
LRRLSVFAGG CDLAAAEEVC AGDGVEGYEV AGLLGSLIDK SLVVAAPTGT GSGTGPGGQM
RYRLLETVGE YAAERLDEAG ERAATEHRHL VAYRELARTR DPLLRGPGQR AAMEQLELEH
DNLRTALRRA VAAGDEHEAL CLVLSLHWFW WLRDHRSDAR HWALAVAALG PNPFLPPVEP
APELYERPID APPPMAPEQL LEARREVRLV ALSSMDSDIE ALGRPEVQDE LAGILAAYRI
GMPQTCKVPG VMWHYAVLLT GHFEELAELI DSAVAACREL GYAWELAYVL QLRSKIFNDR
PGKLPRAARD SDEALQIFLR VGDAWGAAEA LAGRAETHEK RGAYEPAAAD LRAAMEHAER
LGAHGQTLLL RCRLGAVLIE NGQGDAGERM LREVLVTAAK GNSGRDTEPF ARMTLAMRLT
MTGRYDEARS ELNAVRELFT PRAPDLFVGL LESALISLDL DDGHRDEGLL TRFRAALEML
QDRLALMVAP DLPVVQLLTG ARVLMAVRGA PAGRDAARLV GAYDALRAAT HVPALIVRDD
RARTEAAVRA MLDEAVFEKA YAEGGGLSLE EATALI
//
