ID A0A1D7VLS0_9ACTN Unreviewed; 377 AA.
AC A0A1D7VLS0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:AOP47706.1};
GN ORFNames=SL103_16900 {ECO:0000313|EMBL:AOP47706.1};
OS Streptomyces lydicus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=47763 {ECO:0000313|EMBL:AOP47706.1, ECO:0000313|Proteomes:UP000094094};
RN [1] {ECO:0000313|EMBL:AOP47706.1, ECO:0000313|Proteomes:UP000094094}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=103 {ECO:0000313|EMBL:AOP47706.1,
RC ECO:0000313|Proteomes:UP000094094};
RA Jia N., Ding M.-Z., Gao F., Yuan Y.-J.;
RT "Complete genome sequencing of Streptomyces lydicus 103 and metabolic
RT pathways analysis of antibiotic biosynthesis.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP017157; AOP47706.1; -; Genomic_DNA.
DR RefSeq; WP_069569850.1; NZ_CP017157.1.
DR AlphaFoldDB; A0A1D7VLS0; -.
DR KEGG; slc:SL103_16900; -.
DR OrthoDB; 241504at2; -.
DR Proteomes; UP000094094; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08282; PFDH_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF3; GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000094094};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 25..137
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 185..255
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 377 AA; 40338 MW; 4566A4B16A03CBE6 CRC64;
MKAVVYKGPF TVAVENVEKP NIQHPNEALV RITSTAICGS DLHMYEGRTA AEPGIVFGHE
NMGVIEEVGQ GVTSLKEGDR VVMPFNVACG FCTNCVEGFT GFCLTVNPGF AGGAYGYVAM
GPWVGGQAEY LRVPYADFNC LKLPPGNEHE TDFILLADIF PTGYHGCELA QVRPGESVAV
YGGGPVGLMA AYSAMLRGAS KVFVVDRVAE RLEKAREIGA VPINFAEGNP VQQIKDQTDG
AGTDKGVDAV GYQAMAHGEA REEPATVLNS LVETVRPTGA LGVPGLYVPA DPGGPDEEAK
RGMLLVSIGK LFEKGLRMGT GQCNVKRYNR QLRDMIVAGR AKPSFVVSHE LPLDQAPSAY
EKFDKRIEGY TKVVLHP
//