ID A0A1D7VPT3_9ACTN Unreviewed; 817 AA.
AC A0A1D7VPT3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=SL103_23230 {ECO:0000313|EMBL:AOP48772.1};
OS Streptomyces lydicus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=47763 {ECO:0000313|EMBL:AOP48772.1, ECO:0000313|Proteomes:UP000094094};
RN [1] {ECO:0000313|EMBL:AOP48772.1, ECO:0000313|Proteomes:UP000094094}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=103 {ECO:0000313|EMBL:AOP48772.1,
RC ECO:0000313|Proteomes:UP000094094};
RA Jia N., Ding M.-Z., Gao F., Yuan Y.-J.;
RT "Complete genome sequencing of Streptomyces lydicus 103 and metabolic
RT pathways analysis of antibiotic biosynthesis.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
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DR EMBL; CP017157; AOP48772.1; -; Genomic_DNA.
DR RefSeq; WP_069570891.1; NZ_CP017157.1.
DR AlphaFoldDB; A0A1D7VPT3; -.
DR KEGG; slc:SL103_23230; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000094094; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152:SF2; DRUG RESISTANCE ABC TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000094094};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 466..808
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 521..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..535
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 817 AA; 87071 MW; D74BBC51C6048A36 CRC64;
MADSYVRVRG AREHNLRNCD VDIPRDALVA FTGVSGSGKS SLAFGTLYAE AQRRYFESVA
PYARRLIHQV GAPKVEDITG LPPAVALEQR RSAPTSRSSV GTVTTLSNTL RMLFSRAGTY
PEGTTERLDS DAFSPNTAAG ACPECHGLGT VHRVTEDSLV PDPARSVREG AVAAWPGAWQ
GKNLRDILAA LGHDIDRPWR ELPQADRDWI LFTDEEPVVT VHPVREAGRI QRPYQGRYMS
AKRYVLHTFA DSKSEALRKR VQGFMTAEPC PVCGGRRLRP EALAVTFAGQ DIATLAGMPL
GALAELLRPT AARTDDEAAP TLARDLVARI EVLTELGLGY LSTDRPSPTL SAGELQRLRL
ATQLRSGLFG VVYVLDEPSA GLHPADTESL LTVLGRLKEA GNSLFVVEHD MDVVRRADWI
VDVGPRAGEH GGRVLHSGPV AALADAEASA TRRYLFATEP PAARTPRSPS GAVTLRGATL
HNLRGLDATF PLGVFTAVTG VSGSGKTTLV TRVLAEAVRD HLGAGRTETD EDAADTGPTA
RPQLDGAEGL AAVDRLVRVD QKPIGRTPRS NLATYTGLFD AVRKVFAATD EARARGYTAG
RFSFNVAGGR CETCQGEGFV AVELLFLPGT YAPCTDCHGA RYNPETLQIT YRGRTVADVL
AMTVDDAAGF LTDLPAAARS LRTLQDVGLG YLRLGQPATE LSGGEAQRIK LAAELQRTRR
GHTLYLLDEP TTGLHPADTE VLMRQLHGLV DAGHTVVVVE HDMGVVAGAD HVIDLGPGGG
ADGGRIVAAG TPAEVAAAPG SRTARYLARR RGQPGAV
//
