ID A0A1D7VRL7_9ACTN Unreviewed; 815 AA.
AC A0A1D7VRL7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=SL103_26930 {ECO:0000313|EMBL:AOP49395.1};
OS Streptomyces lydicus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=47763 {ECO:0000313|EMBL:AOP49395.1, ECO:0000313|Proteomes:UP000094094};
RN [1] {ECO:0000313|EMBL:AOP49395.1, ECO:0000313|Proteomes:UP000094094}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=103 {ECO:0000313|EMBL:AOP49395.1,
RC ECO:0000313|Proteomes:UP000094094};
RA Jia N., Ding M.-Z., Gao F., Yuan Y.-J.;
RT "Complete genome sequencing of Streptomyces lydicus 103 and metabolic
RT pathways analysis of antibiotic biosynthesis.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; CP017157; AOP49395.1; -; Genomic_DNA.
DR RefSeq; WP_069571526.1; NZ_CP017157.1.
DR AlphaFoldDB; A0A1D7VRL7; -.
DR KEGG; slc:SL103_26930; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000094094; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 2.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:AOP49395.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000094094};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 21..476
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 783..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 448..475
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 815 AA; 88572 MW; 0D666EA0BE6BC36C CRC64;
MARRSTKTPP PDDFEERILD IDVVDEMQGS FLEYAYSVIY SRALPDARDG LKPVHRRILY
QMNEMGLRPE RGYVKCARVV GEVMGKLHPH GDASIYDALV RMAQPFSMRV PLVDGHGNFG
SLGNDDPPAA MRYTECRMAS ATSLMTESID EDTVDFAPNY DGQEKEPVAL PAAYPNLLVN
GASGIAVGMA TNMPPHNLGE VIAAARHLIK HPNADLDTLM RFVPGPDLPT GGRIVGLGGV
RDAYEKGRGT FKIRATVTVE NVTARRKGLV VTELPFTVGP EKVISKIKDL VGSKKLQGIA
DVKDLTDREH GLRLVIEVKN GFNPEAVLEQ LYKLTPMEES FGINNVALVD GQPLTLGLKE
LLEVYVDHRF DVVRRRSEFR RTKRRDRLHL VEGLLTALVD IDEVIRLIRS SENSAQAKER
LIERFSLSDI QTQYILDTPL RRLTKFDRIE LESERDRLQD EIEKLTRILE SDAELRKLVS
NELAAVAKQY GTDRRTVLLE SAGTTVGAVP LEVADDPCRV LLSSTGLLAR TVTGEVPFDA
DAKRVKHDVI ISAVPATTRG EVGAVTSLGR LLRLSVVDLP QLPETAAAPS LSGGAPVPEF
LSLQEGEELI CLTTLDESSP GLALGTEQGV VKRVVPDYPA NKEELEVITL KEGDRIIGAA
ELRTGEEDLV FLTDEAQLLR FPASQVRPQG RPAGGMAGIK LGEGAKVIAF SAVDPAGEAM
VFTVAGSHGT LDDSVATAKL TPFDQYPRKG RATGGVRCHR FLKGEECLTL AWAGSAPVRA
ADAKGAPVPL PEPDPRRDGS GVPLTKPVAV LAGPV
//
