ID   A0A1D7Y549_9ACTN        Unreviewed;       391 AA.
AC   A0A1D7Y549;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:AOR30560.1};
GN   ORFNames=BFF78_05405 {ECO:0000313|EMBL:AOR30560.1};
OS   Streptomyces fodineus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1904616 {ECO:0000313|EMBL:AOR30560.1, ECO:0000313|Proteomes:UP000094960};
RN   [1] {ECO:0000313|Proteomes:UP000094960}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW1S1 {ECO:0000313|Proteomes:UP000094960};
RA   Kim M.-K., Kim S.B.;
RT   "Streptomyces puniciscabiei strain:TW1S1 Genome sequencing and assembly.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; CP017248; AOR30560.1; -; Genomic_DNA.
DR   RefSeq; WP_069777212.1; NZ_CP017248.1.
DR   AlphaFoldDB; A0A1D7Y549; -.
DR   KEGG; spun:BFF78_05405; -.
DR   Proteomes; UP000094960; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08282; PFDH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF3; GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          27..137
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          188..288
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   391 AA;  41924 MW;  1528C71E5D72B33B CRC64;
     MKAAVYEGPR TVTVKDVPDA KIEHPCDIIV KITSTNICGS DLHMYEGRTS FESGRTLGHE
     NMGQVVEVGS AVRKVQVGEY VVLPFNIACG FCKQCEQGLT NYCLTMQPEP ALAGAAYGFA
     DMGPYQGGQA ELLRVPYGDF NALRLGQDAA ERQTDYVMLA DIFPTGYHAT EMAHVKPGDQ
     TIVFGAGPVG LMATYSALLK GAGRVWTADH QPDRLRKAEE IGAIPINTAE RNPAEVVKGA
     TLGLGADNGC ECVGYQAHDP QGHEDASLTL NGLIDSVRFT GDIGVVGVFL PQDPGGAEAQ
     GPLEAQGKVP IDFGMMWFKG QRMGTGQAPV KKYNRALRDL IAGGKAKPSF VVSHELSLDE
     APTAYEHFDA RDEGWTKVVL HPNGHGNGHK R
//