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Database: UniProt
Entry: A0A1D7Y7E2_9ACTN
LinkDB: A0A1D7Y7E2_9ACTN
Original site: A0A1D7Y7E2_9ACTN 
ID   A0A1D7Y7E2_9ACTN        Unreviewed;       709 AA.
AC   A0A1D7Y7E2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   08-MAY-2019, entry version 16.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AOR31502.1};
GN   ORFNames=BFF78_11005 {ECO:0000313|EMBL:AOR31502.1};
OS   Streptomyces puniciscabiei.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=164348 {ECO:0000313|EMBL:AOR31502.1, ECO:0000313|Proteomes:UP000094960};
RN   [1] {ECO:0000313|EMBL:AOR31502.1, ECO:0000313|Proteomes:UP000094960}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW1S1 {ECO:0000313|EMBL:AOR31502.1,
RC   ECO:0000313|Proteomes:UP000094960};
RA   Kim M.-K., Kim S.B.;
RT   "Streptomyces puniciscabiei strain:TW1S1 Genome sequencing and
RT   assembly.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; CP017248; AOR31502.1; -; Genomic_DNA.
DR   RefSeq; WP_069778146.1; NZ_CP017248.1.
DR   EnsemblBacteria; AOR31502; AOR31502; BFF78_11005.
DR   GeneID; 34115496; -.
DR   KEGG; spun:BFF78_11005; -.
DR   OrthoDB; 977512at2; -.
DR   BioCyc; GCF_001735805:G1F6R-2296-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000094960; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000094960};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN      340    520       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      524    606       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   709 AA;  75531 MW;  DABEA6AA703E667C CRC64;
     MSTTAELLKQ ASELFPDEVV TSAHVRHLDL PFGAGRFALI TLDNGFDHTK PTTFGPGSLA
     NLNTAIDQVE KEAADGEIVG AGITGKPFIF AVGADLKGVE ILKEREHALA IGKGGHDVFK
     RLANLAVPTF AYYNGAAMGG GVEVGLHCTY RTVSTAVPAF SLPEVFLGLV PGWGGCTLLP
     NLIGADKAVS VIIENSLNQN KQLKGRQVFE LGIADALFEG ADFLEQSLLW TAQVLKGDVQ
     VERPVIDRGE AWDQAVARGR FVADSKVHGA APAAYRALDI VAAAKNGDLQ QGYDAEDQAL
     ADLIMSGELR AGIYAFNLVQ KRGKRPAGAP DKNLARPVTK VGVVGAGLMA SQLALLFLRR
     LEVPVVLTDI DQERVDKGVG YVHAEIDKLL GKGRINQDKA NRLKALVTGV LDKAEGFADA
     DFVIEAVFEE IGVKQQVFAE VEAVAPAHAI LATNTSSLSV TEMASKLKHP ERVVGFHFFN
     PVAVLPLLEI VRGEQTDDAS LATAFAVAKK LKKTAVLVKD APAFVVNRIL TRFMGEIQNV
     IDEGTPVEVA EKAVEPLGLP MSPLVLLELV GPAIGLHVSE TLNRAFPDRF TVSPNLAAVV
     KAGKRGFYVY DSGKPELDPE VAALLKQGDS VLTEEQVRER VLDAVAQEIG LMLDEGVVAE
     AQDIDLCLIT GAGWPFHLGG ITPYLDREGV SERVNGKKFL APGVASVPA
//
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