ID A0A1D7YGP4_9ACTN Unreviewed; 341 AA.
AC A0A1D7YGP4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Daunorubicin/doxorubicin resistance ABC transporter ATP-binding protein DrrA {ECO:0000313|EMBL:AOR34704.1};
GN ORFNames=BFF78_29910 {ECO:0000313|EMBL:AOR34704.1};
OS Streptomyces fodineus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1904616 {ECO:0000313|EMBL:AOR34704.1, ECO:0000313|Proteomes:UP000094960};
RN [1] {ECO:0000313|Proteomes:UP000094960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW1S1 {ECO:0000313|Proteomes:UP000094960};
RA Kim M.-K., Kim S.B.;
RT "Streptomyces puniciscabiei strain:TW1S1 Genome sequencing and assembly.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP017248; AOR34704.1; -; Genomic_DNA.
DR RefSeq; WP_069781250.1; NZ_CP017248.1.
DR AlphaFoldDB; A0A1D7YGP4; -.
DR KEGG; spun:BFF78_29910; -.
DR Proteomes; UP000094960; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF18; DOXORUBICIN RESISTANCE ATP-BINDING PROTEIN DRRA; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:AOR34704.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 15..245
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 341 AA; 36596 MW; 56A45DF68105D73E CRC64;
MTRIHENPVG ASHAVTVRGL VKHYGETKAL DGVDLDVREG TVMGVLGPNG AGKTTLVRIL
STLLTPDAGQ ATVAGYDVVR QPRQLRRVIG LTGQYASVDE KLPGWENLYM IGRLLDLSRK
DARARADELL ERFSLTEAAR RPASTYSGGM RRRLDLAASM IGRPAVLYLD EPTTGLDPRT
RNEVWDEVQA MVGDGVTVLL TTQYMEEAEQ LASELTVVDR GKVIATGGIE ELKARVGGRT
LRIRPVDPLQ LRPLATTLDE LGITGLAATT VDTESGTLLV PILSDEQLTA VVGAVTARGI
TISSITTELP SLDEVFLSLT GHRAGAPQDI TPADTREEVA A
//
